Drug & supplement interaction

7-keto-dhea + Valproic Acid

Valproic Acid brand names: Depakene, Depacon, Valproate.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between 7-keto-dhea and Valproic Acid in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Valproic Acid states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

7-keto-dhea and Valproic Acid

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Valproic Acid and 7-keto-dhea in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for 7-keto-dhea at all — not against Valproic Acid, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

7-keto-dhea safety at a glance

7-keto-dhea overall Use caution Short-term use appears generally tolerated in small studies, but long-term safety is not well established.
Pregnancy Avoid Not enough safety data, and hormone-related supplements are best avoided during pregnancy.
Breastfeeding Avoid No reliable safety information is available, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Valproic Acid and 7-keto-dhea? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests 7-keto-dhea and Valproic Acid May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Dizziness Additional detail

    7-keto-dhea

    “Orally, 7-keto-DHEA has been associated with one report of vertigo in one clinical study.”

    7-keto-dhea · Natural Medicines adverse-effect record, reported in vertigo.

    1 source cited
    1. 92185. Zenk JL, Frestedt JL, Kuskowski MA. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem 2007;18(9):629-34. PubMed

    Valproic Acid

    Listed in the ADVERSE REACTIONS section of the FDA label for Valproic Acid. Read the label on DailyMed ›

  • Nausea Additional detail

    7-keto-dhea

    “Orally, 7-keto-DHEA has been associated with two reports of nausea in one clinical study.”

    7-keto-dhea · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 92185. Zenk JL, Frestedt JL, Kuskowski MA. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem 2007;18(9):629-34. PubMed

    Valproic Acid

    Listed in the ADVERSE REACTIONS section of the FDA label for Valproic Acid. Read the label on DailyMed ›

Effects for Valproic Acid come from the ADVERSE REACTIONS section of its FDA label; effects for 7-keto-dhea come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 30,892 voluntary FDA FAERS reports for Valproic Acid that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Valproic Acid Products Have a Food Rule — 7-keto-dhea Should Not Break It

At least one FDA label for a product containing Valproic Acid says to take it with food. If you take 7-keto-dhea on an empty stomach out of habit, keep them separate — and take Valproic Acid with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Valproic Acid products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

irritation may benefit from administration of the drug with food or by slowly building up the dose from an initial low level.

From the Dosage and Administration section of the FDA label we read for Valproic Acid — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Valproic Acid Is Prescribed For, and What 7-keto-dhea Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Valproic Acid is a prescription medicine with approved uses on its FDA label. 7-keto-dhea is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Valproic Acid is prescribed for: Valproic acid capsules (brands Valproic and Valproic Acid) and valproic acid oral solution (brand Valproic Acid) are both used to treat epilepsy. Specifically, they are approved for complex partial seizures (either alone or with other seizure types) as monotherapy or add-on therapy, and for simple and complex absence seizures as sole therapy or add-on therapy. Both forms are intended for adults and pediatric patients. Always follow your prescriber's guidance on which product and regimen is right for you.

7-keto-dhea has been studied for:

  • Depression studied, not established 7-keto-dhea has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    7-keto-dhea for depression

    Although there has been interest in using oral 7-keto-DHEA for depression, there is insufficient reliable information about the clinical effects of 7-keto-DHEA for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Valproic Acid on your own; if you are taking 7-keto-dhea for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About 7-keto-dhea or Valproic Acid

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers 7-keto-dhea or Valproic Acid, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Valproic Acid

This page covers 7-keto-dhea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Valproic Acid page lists 173 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 9 major · 147 moderate · 17 minor.

From our pharmacist’s overview on the Valproic Acid page

“Anyone taking valproic acid (Depakene, Depacon) for seizures or bipolar disorder should treat this list with genuine care. Of the 173 supplements and herbs on file, nine are rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Valproic Acid interaction page

One more smart check

Taking 7-keto-dhea as Part of a Dietary Supplement Product? Check It for Interactions

We hold 207 real supplement products containing 7-keto-dhea, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 7-keto-dhea. Even though 7-keto-dhea itself has no known interaction with Valproic Acid, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 7-keto-dhea and Valproic Acid Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 7-keto-dhea
Steady interest

#777 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Valproic Acid
Top half

#773 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 7-keto-dhea reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The 7-keto-dhea and Valproic Acid records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 7-keto-dhea

What is 7-keto-dhea?

7-keto-dhea
  • Weight loss and fat burning
  • Boosting metabolism
  • Supporting muscle mass
  • Improving body composition
  • Anti-aging support

7-keto-DHEA is a lab-made metabolite of the hormone DHEA that is marketed mainly for weight loss and a faster metabolism. Unlike DHEA, it is not thought to convert into estrogen or testosterone, but the evidence that it helps with weight or metabolism is limited and comes from small studies. Talk with your pharmacist or doctor before trying it, especially if you have any health conditions.

Not applicable (a manufactured metabolite of DHEA) · Capsules, tablets, powders (often in weight-loss or 'metabolism' blends)

An interaction check asks whether these two react with each other — it does not ask whether 7-keto-dhea is a good idea for someone in your situation. Here is what our 7-keto-dhea record says about it on its own.

7-keto-dhea: dosing

There is no official or well-established standardized dose for 7-keto-DHEA. Doses used in studies and on product labels have varied, and we cannot recommend a specific amount.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount.

From our 7-keto-dhea monograph — the full record covers uses, side effects and every documented interaction.

Read the full 7-keto-dhea monograph & all interactions
Medication

About Valproic Acid

What Is Valproic Acid Used For?

Brand names: Depakene, Depacon, Valproate

Valproic acid capsules (brands Valproic and Valproic Acid) and valproic acid oral solution (brand Valproic Acid) are both used to treat epilepsy. Specifically, they are approved for complex partial seizures (either alone or with other seizure types) as monotherapy or add-on therapy, and for simple and complex absence seizures as sole therapy or add-on therapy.

Both forms are intended for adults and pediatric patients. Always follow your prescriber's guidance on which product and regimen is right for you.

See full Valproic Acid drug information
Keep checking

Other Drugs & 7-keto-dhea

Browse every other medication we’ve checked against 7-keto-dhea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked 7-keto-dhea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full 7-keto-dhea list.

See the full 7-keto-dhea interactions page
See every supplement checked against Valproic Acid, ranked by severity
Evidence & sources

7-keto-dhea References

The 2 references that drive our 7-keto-dhea monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Davidson M, Marwah A, Sawchuk RJ, et al. Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. Clin Invest Med 2000;23:300-10..
  2. Zenk JL, Frestedt JL, Kuskowski MA. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem 2007;18(9):629-34. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 7-keto-dhea and Valproic Acid Together: Common Questions

Is it safe to take 7-keto-dhea with Valproic Acid?
We do not list a known interaction between 7-keto-dhea and Valproic Acid. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do 7-keto-dhea and Valproic Acid have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take 7-keto-dhea and Valproic Acid at the same time of day?
At least one FDA label for a product containing Valproic Acid says to take it with food. If you take 7-keto-dhea on an empty stomach out of habit, keep them separate and take Valproic Acid with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Valproic Acid products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are 7-keto-dhea and Valproic Acid used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for 7-keto-dhea in each. That is a conversation for your prescriber, especially if Valproic Acid is being adjusted to a target.
Does Valproic Acid interact with any supplements?
Yes. Valproic Acid has documented interactions with 173 supplements in our database — 7-keto-dhea is not one of them. The Valproic Acid interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

7-keto-dhea monograph Uses, safety profile, and every drug interaction in one place Valproic Acid drug information The full plain-English guide to this medication Valproic Acid supplement interactions Every supplement checked against Valproic Acid, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Valproic Acid and 7-keto-dhea?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.