Medication interaction hub

What Supplements Interact with Valproic Acid?

Valproic Acid brand names: Depakene, Depacon, Valproate. Every interaction below applies to the brands too.

173 Interactions 9 Major 147 Moderate 17 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Valproic Acid? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Valproic Acid against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Anyone taking valproic acid (Depakene, Depacon) for seizures or bipolar disorder should treat this list with genuine care. Of the 173 supplements and herbs on file, nine are rated major. The largest cluster, 78 ingredients including kava and the alcohol in beer or wine, adds to the drug's own sedation, in bad cases deepening into dangerous drowsiness or slowed breathing. Another 38 can stress the liver, which matters because valproic acid itself carries a liver-injury warning.

The frustrating part is that supplements marketed for sleep and mood, the very things a person on this drug might reach for, dominate the sedating and serotonin-affecting groups. Activated charcoal is another major entry; it can soak up the medicine before it is absorbed. Smaller clusters add sun sensitivity or interfere with anything swallowed. Learn the nine major entries first, and remember the 147 moderate ones add up when several are stacked together.

— , Clinical Pharmacist · July 18, 2026

Major 9 Moderate 147 Minor 17 No known interaction 1,279

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Valproic Acid: Top Interactions at a Glance

The Valproic Acid supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 173 interacting ingredients — plus 1,279 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Valproic Acid Combinations Today

The Valproic Acid + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Black Tea + Valproic Acidi

Theoretically, black tea might reduce the effects of valproate and increase the risk for convulsions.

Read the full interaction Moderate Likelihood Possible Vitamin A + Valproic Acidi

Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.

Read the full interaction Moderate Likelihood Possible Guarana + Valproic Acidi

Theoretically, guarana might reduce the effects of valproate and increase the risk for convulsions.

Read the full interaction Moderate Likelihood Probable Chenopodium Oil + Valproic Acidi

Theoretically, concomitant use of chenopodium oil with other photosensitizing drugs can increase the risk of adverse effects.

Read the full interaction Moderate Likelihood Possible 5-htp + Valproic Acidi

Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.

Read the full interaction Moderate Likelihood Possible St. John's Wort + Valproic Acidi

Theoretically, St.

Read the full interaction
The complete list

Every Supplement Checked Against Valproic Acid

All 1,452 ingredients in our database, ranked by severity — 173 with a Valproic Acid interaction on file and 1,279 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Valproic Acid?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Tea with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black tea might reduce the effects of valproate and increase the risk for convulsions.

Full Black Tea + Valproic Acid answer

Can you take Vitamin A with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disea...

Full Vitamin A + Valproic Acid answer

Can you take Guarana with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guarana might reduce the effects of valproate and increase the risk for convulsions.

Full Guarana + Valproic Acid answer

Can you take Chenopodium Oil with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of chenopodium oil with other photosensitizing drugs can increase the risk of adverse effects.

Full Chenopodium Oil + Valproic Acid answer

Can you take 5-htp with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.

Full 5-htp + Valproic Acid answer

Can you take Mace with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Several volatile oils in mace, such as methyleugenol, isoeugenol, safrole, myristicin, 1,8-cineole, and geranyl acetate, seem to have sedati...

Full Mace + Valproic Acid answer

Can you take Magnolia with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.

Full Magnolia + Valproic Acid answer

Can you take Manchurian Thorn with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that high doses of Manchurian thorn can induce liver damage.

Full Manchurian Thorn + Valproic Acid answer

Can you take Marsh Labrador Tea with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Marsh Labrador tea can potentiate effects of barbiturates and alcohol.

Full Marsh Labrador Tea + Valproic Acid answer

Can you take Melatonin with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin might increase the sedative effects of CNS depressants.

Full Melatonin + Valproic Acid answer

Can you take Methylene Blue with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with methylene blue can cause additive serotonergic effects, including serotonin syndrome.

Full Methylene Blue + Valproic Acid answer

Can you take Motherwort with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.

Full Motherwort + Valproic Acid answer

Can you take Niacin with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Full Niacin + Valproic Acid answer

Can you take Noni with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.

Full Noni + Valproic Acid answer

Can you take Nutmeg with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nutmeg might increase the risk of additive sedation when taken with CNS depressants.

Full Nutmeg + Valproic Acid answer

Can you take Oolong Tea with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oolong tea might reduce the effects of valproate and increase the risk for convulsions.

Full Oolong Tea + Valproic Acid answer

Can you take Oregon Grape with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the sedative effects of CNS depressants.

Full Oregon Grape + Valproic Acid answer

Can you take Ostarine with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.

Full Ostarine + Valproic Acid answer

Can you take Padang Cassia with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that ingesting large amounts of Padang cassia might cause hepatotoxicity in some people.

Full Padang Cassia + Valproic Acid answer

Can you take Passion Flower with Valproic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.

Full Passion Flower + Valproic Acid answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Valproic Acid is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Valproic Acid, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Valproic Acid sits in 8 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Valproic Acid through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Valproic Acid through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Valproic Acid through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Valproic Acid through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Valproic Acid through this category.

Anticonvulsants 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Valproic Acid through this category.

Valproate 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Valproic Acid through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Valproic Acid through this category.

About Valproic Acid

Valproic acid is an anticonvulsant used to treat seizures, mania in bipolar disorder, and prevent migraine headaches.

Generic name: Valproic Acid  ·  Brand names: Depakene, Depacon, Valproate.

See the full Valproic Acid drug information

Related: does Valproic Acid deplete any nutrients?

Valproic Acid has 27 reported nutrient associations in the research literature — see the Valproic Acid nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Valproic Acid

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Valproic Acid.

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Products that contain Valproic Acid-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Valproic Acid.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Valproic Acid & Supplements: Common Questions

What supplements interact with Valproic Acid?
In our interaction database, 173 supplement and herbal ingredients have an interaction with Valproic Acid on file — 9 rated major, 147 moderate, and 17 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Beer, Siberian Cocklebur, Wine.
Which Valproic Acid supplement interactions are the most serious?
The 9 major-rated combinations — led by Beer, Siberian Cocklebur, Wine, 1,4-butanediol and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Valproic Acid?
That depends entirely on which supplement. The honest answer for Valproic Acid is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Depakene have the same supplement interactions as Valproic Acid?
Yes — Depakene, Depacon, Valproate all contain Valproic Acid, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Valproic Acid deplete any vitamins or nutrients?
It might — Valproic Acid has 27 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Valproic Acid nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Valproic Acid and my other medications?
This page covers Valproic Acid against supplements and herbal ingredients. Checking Valproic Acid against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Valproic Acid drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.