Drug & supplement interaction

Chaulmoogra + Valproic Acid

Valproic Acid brand names: Depakene, Depacon, Valproate.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Chaulmoogra and Valproic Acid in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Valproic Acid states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Chaulmoogra and Valproic Acid

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Valproic Acid and Chaulmoogra in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Chaulmoogra at all — not against Valproic Acid, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chaulmoogra safety at a glance

Chaulmoogra overall Use caution Largely outdated remedy with limited modern safety data and a history of irritation and side effects.
Pregnancy Avoid Not enough safety information; avoid during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Valproic Acid and Chaulmoogra? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Chaulmoogra and Valproic Acid May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Shortness of breath Worth acting on Additional detail

    Chaulmoogra

    “Orally, ingestion of the seed can cause cough, dyspnea, laryngospasms, nephrotoxicity, visual disorders, head and muscle pain, and central paralysis (18).

    Topically, use can cause skin irritation (18).”

    Chaulmoogra · Natural Medicines adverse-effect record, reported in cough.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Valproic Acid

    Listed in the ADVERSE REACTIONS section of the FDA label for Valproic Acid. Read the label on DailyMed ›

  • Cough / Muscle pain Additional detail

    Chaulmoogra

    Recorded for Chaulmoogra in the same Natural Medicines adverse-effect record shown under Shortness of breath above.

    Valproic Acid

    Listed in the ADVERSE REACTIONS section of the FDA label for Valproic Acid. Read the label on DailyMed ›

Reported for Chaulmoogra but not commonly for Valproic Acid: kidney problems.

Effects for Valproic Acid come from the ADVERSE REACTIONS section of its FDA label; effects for Chaulmoogra come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 30,892 voluntary FDA FAERS reports for Valproic Acid that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Valproic Acid Products Have a Food Rule — Chaulmoogra Should Not Break It

At least one FDA label for a product containing Valproic Acid says to take it with food. If you take Chaulmoogra on an empty stomach out of habit, keep them separate — and take Valproic Acid with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Valproic Acid products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

irritation may benefit from administration of the drug with food or by slowly building up the dose from an initial low level.

From the Dosage and Administration section of the FDA label we read for Valproic Acid — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Chaulmoogra or Valproic Acid

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Chaulmoogra or Valproic Acid, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Valproic Acid

This page covers Chaulmoogra only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Valproic Acid page lists 173 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 9 major · 147 moderate · 17 minor.

From our pharmacist’s overview on the Valproic Acid page

“Anyone taking valproic acid (Depakene, Depacon) for seizures or bipolar disorder should treat this list with genuine care. Of the 173 supplements and herbs on file, nine are rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Valproic Acid interaction page

How much people look this up

Where Chaulmoogra and Valproic Acid Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chaulmoogra
Steady interest

#1,157 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Valproic Acid
Top half

#773 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chaulmoogra reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chaulmoogra and Valproic Acid records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chaulmoogra

What is Chaulmoogra?

  • Leprosy (historical)
  • Skin conditions and rashes
  • Wound and sore care
  • Eczema and psoriasis (traditional)
  • Rheumatic complaints (traditional)

Chaulmoogra oil is an old herbal remedy famous for being the main treatment for leprosy before modern antibiotics. Today it has been replaced by safer, more effective drugs, and there is little reliable modern evidence to support its use. If you are considering it, talk to a pharmacist or doctor first, and avoid it during pregnancy and breastfeeding.

Hydnocarpus kurzii · Achariaceae · Seed oil (chaulmoogra oil) and seeds · Seed oil, topical preparations, and historically injectable oil derivatives

An interaction check asks whether these two react with each other — it does not ask whether Chaulmoogra is a good idea for someone in your situation. Here is what our Chaulmoogra record says about it on its own.

Chaulmoogra: dosing

There is no established, standardized dose for chaulmoogra in modern use, and it is not a recommended treatment today. Historical doses varied widely and were used under medical supervision in an era before modern drugs.If you find a product that contains chaulmoogra, follow the directions on the label and do not use it internally.

From our Chaulmoogra monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chaulmoogra monograph & all interactions
Medication

About Valproic Acid

What Is Valproic Acid Used For?

Brand names: Depakene, Depacon, Valproate

Valproic acid capsules (brands Valproic and Valproic Acid) and valproic acid oral solution (brand Valproic Acid) are both used to treat epilepsy. Specifically, they are approved for complex partial seizures (either alone or with other seizure types) as monotherapy or add-on therapy, and for simple and complex absence seizures as sole therapy or add-on therapy.

Both forms are intended for adults and pediatric patients. Always follow your prescriber's guidance on which product and regimen is right for you.

See full Valproic Acid drug information
Keep checking

Other Drugs & Chaulmoogra

Browse every other medication we’ve checked against Chaulmoogra — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Chaulmoogra against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Chaulmoogra list.

See the full Chaulmoogra interactions page
See every supplement checked against Valproic Acid, ranked by severity
Evidence & sources

Chaulmoogra References

The 1 references that drive our Chaulmoogra monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chaulmoogra and Valproic Acid Together: Common Questions

Is it safe to take Chaulmoogra with Valproic Acid?
We do not list a known interaction between Chaulmoogra and Valproic Acid. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Chaulmoogra and Valproic Acid have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Chaulmoogra and Valproic Acid at the same time of day?
At least one FDA label for a product containing Valproic Acid says to take it with food. If you take Chaulmoogra on an empty stomach out of habit, keep them separate and take Valproic Acid with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Valproic Acid products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Valproic Acid interact with any supplements?
Yes. Valproic Acid has documented interactions with 173 supplements in our database — Chaulmoogra is not one of them. The Valproic Acid interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chaulmoogra monograph Uses, safety profile, and every drug interaction in one place Valproic Acid drug information The full plain-English guide to this medication Valproic Acid supplement interactions Every supplement checked against Valproic Acid, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Valproic Acid and Chaulmoogra?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.