Androstenediol + Acetaminophen, Aspirin, Caffeine
Acetaminophen, Aspirin, Caffeine brand names: Excedrin Migraine, Excedrin, Excedrin Extra Strength.
We found no known interaction between Androstenediol and Acetaminophen, Aspirin, Caffeine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Androstenediol and Acetaminophen, Aspirin, Caffeine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Acetaminophen, Aspirin, Caffeine and Androstenediol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Androstenediol safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Acetaminophen, Aspirin, Caffeine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Acetaminophen, Aspirin, Caffeine is filed under 17 classifications — including caffeine, aspirin, methylxanthines. Androstenediol has documented interactions with 2 drug classes — the most serious being estrogens (moderate) and testosterone (moderate) — and none of Acetaminophen, Aspirin, Caffeine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Androstenediol Does Interact With Other Medications
Androstenediol has 47 moderate known drug interactions in our database — Acetaminophen, Aspirin, Caffeine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Androstenediol
We haven’t checked that one against Androstenediol yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Androstenediol. Pick one to open its full report.
See Every Supplement That Interacts With Acetaminophen, Aspirin, Caffeine
This page covers Androstenediol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Aspirin, Caffeine page lists 371 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Ephedra (major).
By severity: 13 major · 312 moderate · 46 minor.
From our pharmacist’s overview on the Acetaminophen, Aspirin, Caffeine page
“Excedrin (acetaminophen, aspirin, and caffeine) packs three drugs into one tablet, which multiplies the ways supplements can collide with it, so treat this list with real care. Most entries involve the aspirin: hundreds of herbs add to its blood-thinning effect and raise bleeding risk, and even beer or wine earns a major rating for sto…”
Reviewed by 2 · Jul 18, 2026
Where Androstenediol and Acetaminophen, Aspirin, Caffeine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,418 of 1,452 supplements looked up here in the last 7 days
#77 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Androstenediol reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Androstenediol and Acetaminophen, Aspirin, Caffeine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Androstenediol
What is Androstenediol?
- Boosting testosterone
- Building muscle and strength
- Enhancing athletic performance
- Anti-aging / general vitality
- Bodybuilding cutting or bulking cycles
Androstenediol is a prohormone (a precursor the body can convert into testosterone and other hormones) marketed to raise testosterone and build muscle, but solid human evidence for these benefits is lacking and it carries real hormonal risks. In the United States it is a Schedule III controlled substance and is banned in most competitive sports. Talk with a doctor or pharmacist before considering any product containing it.
Not a plant; a steroid hormone (prohormone) made synthetically or naturally in the body · Capsules, tablets, sublingual tablets, sprays (sold as 'prohormone' supplements)
An interaction check asks whether these two react with each other — it does not ask whether Androstenediol is a good idea for someone in your situation. Here is what our Androstenediol record says about it on its own.
Androstenediol: dosing
There is no established safe or effective dose of androstenediol, and because it is a controlled substance, it is not a routine over-the-counter supplement. The body of research does not support a recommended amount.If you are considering any product that contains it, do not rely on label claims.
From our Androstenediol monograph — the full record covers uses, side effects and every documented interaction.
About Acetaminophen, Aspirin, Caffeine
Most-Reported Side Effects for Acetaminophen, Aspirin, Caffeine
From FAERS, the FDA’s public side-effect reporting system (442 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Androstenediol
Browse every other medication we’ve checked against Androstenediol — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
47 interactions
- Estradiol ›
- Testosterone ›
- Methyltestosterone ›
- Conjugated Estrogens ›
- Testosterone Undecanoate ›
- Esterified Estrogens ›
- Estropipate ›
- Methyltestosterone Buccal ›
- Estrogen ›
- Estrone ›
- Ethinyl Estradiol ›
- Oestrogen ›
- Prasterone (prescription Drug) ›
- Testosterone Enanthate ›
- Tibolone ›
- Ethinyl Estradiol, Norethindrone ›
- Ethinyl Estradiol, Levonorgestrel ›
- Ethinyl Estradiol, Norgestimate ›
- Ethinyl Estradiol, Desogestrel ›
- Ethinyl Estradiol, Norethindrone, Ferrous Fumarate ›
- Desogestrel, Ethinyl Estradiol ›
- Ethinyl Estradiol, Ethynodiol Diacetate ›
- Levonorgestrel, Ethinyl Estradiol ›
- Ethinyl Estradiol, Norgestrel ›
- Drospirenone, Ethinyl Estradiol ›
- Conjugated Estrogens, Medroxyprogesterone Acetate ›
- Conjugated Estrogens, Meprobamate ›
- Cyproterone Acetate, Ethinyl Estradiol ›
- Ethiny Estradiol, Levonorgestrel ›
- Norelgestromin, Ethinyl Estradiol ›
- Norethindrone Acetate, Ethinyl Estradiol, Ferrous Fumarate ›
- Bazedoxifene Acetate, Conjugated Estrogens ›
- Conjugated Estrogens, Methyltestosterone ›
- Diethylstilbestrol, Methyltestosterone ›
- Drospirenone, Estetrol ›
- Drospirenone, Ethinyl Estradiol, Levomefolate ›
- Esterified Estrogens, Methyltestosterone ›
- Estradiol, Medroxyprogesterone ›
- Estradiol, Norethindrone Acetate ›
- Estradiol, Norgestimate ›
- Estradiol, Progesterone ›
- Ethinyl Estradiol, Drospirenone ›
- Ethinyl Estradiol, Levonogestrel ›
- Etonogestrel, Ethinyl Estradiol ›
- Medroxyprogesterone Acetate, Oestrogens, Conjugated ›
- Relugolix, Estradiol, Norethindrone Acetate ›
- Segesterone Acetate, Ethinyl Estradiol ›
No interaction 2,782 drugs checked — show the list
We also checked Androstenediol against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Rivaroxaban ›
- Aspirin ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Abemaciclib ›
- Clopidogrel ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Valacyclovir ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Amitriptyline ›
- Methotrexate ›
- Bendamustine ›
- Acyclovir ›
- Doxycycline ›
- Amphetamine ›
- Fluoxetine ›
- Isotretinoin ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amlodipine Besylate ›
- Dextroamphetamine ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,782 medications checked with no known interaction — see the full Androstenediol list.
Androstenediol References
The 3 references that drive our Androstenediol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000;160:30
- Brown GA, Martini ER, Roberts BS, et al. Acute hormonal response to sublingual androstenediol intake in young men. J Appl Physiol 2002;92:142-6. PubMed
- Battista, V., Combs, J., and Warme, W. J. Asynchronous bilateral achilles tendon ruptures and androstenediol use. Am J Sports Med 2003;31(6):1007-1009. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Acetaminophen, Aspirin, Caffeine Is Linked to Lower Levels of 5 Nutrients
Natural Medicines records Acetaminophen, Aspirin, Caffeine as a medicine that can lower these. This is not an interaction with Androstenediol — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Acetaminophen, Aspirin, Caffeine nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Androstenediol and Acetaminophen, Aspirin, Caffeine Together: Common Questions
Is it safe to take Androstenediol with Acetaminophen, Aspirin, Caffeine?
How was the Androstenediol and Acetaminophen, Aspirin, Caffeine combination checked?
Does Androstenediol interact with any other medications?
Does Acetaminophen, Aspirin, Caffeine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.