Drug & supplement interaction

Artichoke + Carvedilol

Carvedilol brand names: Coreg, Coreg CR.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Artichoke has a moderate interaction with Carvedilol. Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Artichoke and Carvedilol

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Carvedilol

Carvedilol falls under ANTIHYPERTENSIVE DRUGS — the group Artichoke interacts with.

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: carvedilol is already working to lower your blood pressure and slow your heart rate. Artichoke leaf extract may have a mild blood-pressure-lowering effect of its own, so stacking the two could nudge your numbers down a little further than expected. We're not talking about a powerful interaction here, the studies suggest artichoke only trims systolic pressure by about 3 points and diastolic by about 2 on average.

For most people that's minor, but if your pressure runs low or you're sensitive, you might notice more dizziness, lightheadedness, fatigue, or feeling faint when you stand up. This is theoretical and based on how these things work, not strong human proof. Before adding an artichoke supplement, check with your pharmacist or doctor, especially if you already feel lightheaded.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Moradi M, Sohrabi G, Golbidi M, et al. Effects of artichoke on blood pressure: a systematic review and meta-analysis. Complement Ther Med 2021;57:102668. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Artichoke Also Interacts With Other Medications

Artichoke has 362 moderate known drug interactions in our database — the Carvedilol one above is one of them. If you take anything else, check it against the full list below.

Moderate 362 No known interaction 2,468 (incl. Carvedilol)
Taking anything else?

Check Another of Your Medications Against Artichoke

Covers the 2,830 medications we’ve checked against Artichoke. Pick one to open its full report.

From our Q&A

Questions About Artichoke or Carvedilol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Artichoke or Carvedilol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Carvedilol

This page covers Artichoke only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Carvedilol page lists 211 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Grapefruit (major) and Indian Snakeroot (major).

By severity: 6 major · 171 moderate · 34 minor.

From our pharmacist’s overview on the Carvedilol page

“People take carvedilol (Coreg) for heart failure and high blood pressure, conditions where a sudden swing in pressure or heart rate matters, and its supplement list runs to 211 ingredients, so this one calls for genuine care. More than half of those entries lower blood pressure on their own, fish oil and celery seed among them, and can…”

Reviewed by 2 · Jul 18, 2026

Open the Carvedilol interaction page

One more smart check

Taking Artichoke as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,715 real supplement products containing Artichoke, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Artichoke. Your product may carry other ingredients that interact with Carvedilol too, on top of Artichoke — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Artichoke and Carvedilol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Artichoke
Top 25%

#149 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Carvedilol
Top 25%

#323 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Artichoke

What is Artichoke?

Artichoke
  • High cholesterol
  • Indigestion and heartburn
  • Constipation and bloating
  • Liver and gallbladder support
  • General digestive health

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a replacement for proven treatments, so talk with your pharmacist or doctor before using it, especially if you have a medical condition.

Read the full Artichoke monograph & all interactions
Medication

About Carvedilol

What Is Carvedilol Used For?

Brand names: Coreg, Coreg CR

Carvedilol is used to treat three main conditions: mild to severe chronic heart failure, high blood pressure (hypertension), and left ventricular dysfunction (reduced pumping ability of the heart's main chamber) in people who have survived a heart attack. For heart failure, it is typically used alongside other medications such as diuretics, ACE inhibitors, and digitalis to help improve survival and reduce hospital stays.

For people who have had a heart attack with reduced heart function, carvedilol is used to lower the risk of dying from cardiovascular causes. For high blood pressure, it can be used alone or combined with other blood pressure medications.

See full Carvedilol drug information
Keep checking

Other Drugs & Artichoke

Browse every other medication we’ve checked against Artichoke — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
362Moderate
0Minor
2,467No known interaction
362 Moderate 2,467 No interaction
Moderate

362 interactions

Showing 60 of 362 moderate interactions — see all 362 on the Artichoke page.

No interaction 2,467 drugs checked — show the list

We also checked Artichoke against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,467 medications checked with no known interaction — see the full Artichoke list.

See the full Artichoke interactions page
See every supplement checked against Carvedilol, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Artichoke monograph › Uses, safety, and every drug interaction in one place Carvedilol supplement interactions › Every supplement checked against Carvedilol, ranked by severity Carvedilol drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Artichoke and Carvedilol Together: Common Questions

Can you take Artichoke with Carvedilol?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Artichoke and Carvedilol interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Carvedilol and Artichoke?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.