Drug & supplement interaction

Beer + Aspirin, Hydrocodone

Aspirin, Hydrocodone brand names: Alor 5 500, Lortab ASA.

Major Interaction
Medically reviewed by · Updated September 2026
The bottom line Major

Aspirin, Hydrocodone falls into 4 drug categories that Beer can interact with; the most serious is rated major. Concomitant use may increase sedative and other adverse effects.

Read the full interaction report
SeverityMajor
LikelihoodLikely
Interactions4
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

Beer and Aspirin, Hydrocodone

These two interact in 4 distinct ways. Each one is explained separately below.

Why Are There 4 Interactions?

Beer interacts with whole categories of medication. Aspirin, Hydrocodone falls into 4 of those categories, so it can interact with Beer in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Major).

Major

CNS DEPRESSANTS

1 of 4

Why this applies to Aspirin, Hydrocodone

Aspirin, Hydrocodone falls under CNS DEPRESSANTS — the group Beer interacts with.

Concomitant use may increase sedative and other adverse effects.
Concomitant use of alcohol with CNS depressants can increase sedative and other adverse effects, potentially through inhibition of the metabolism of certain CNS depressants.
Severity Major Likelihood Likely Evidence C

Well-controlled human studies have demonstrated the likely existence of this interaction.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combination pill pairs aspirin with hydrocodone, an opioid pain reliever. The bigger concern with beer here is the hydrocodone side. Both alcohol and opioids slow down your brain and breathing, and stacking them adds up fast. Together they can leave you very drowsy, dizzy, confused, or slow to react. In larger amounts the real danger is dangerously slow breathing, which can be life-threatening.

On top of that, the aspirin and alcohol can both be hard on your stomach lining, raising the risk of irritation or bleeding. This is a well-recognized, serious interaction, so please don't drink beer while taking this medication, and check with your pharmacist or doctor if you have questions.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fraser AG. Pharmacokinetic interactions between alcohol and other drugs. Clin Pharmacokinet 1997;33:79-90. PubMed
Major

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)

2 of 4

Aspirin, Hydrocodone also falls under NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs).

Concomitant use may increase the risk of gastrointestinal (GI) bleeding.
Concomitant use of NSAIDs with alcohol can increase the risk of GI bleeding.
Severity Major Likelihood Probable Evidence C

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combination pill pairs aspirin (an NSAID-type blood thinner that's tough on the stomach lining) with hydrocodone (an opioid pain reliever). The concern here is mostly with the aspirin half. Aspirin already irritates your stomach and gut, and adding beer pushes that risk higher. Together, alcohol and aspirin can raise your chance of stomach and intestinal bleeding.

Watch for warning signs like black or tarry stools, vomit that looks like coffee grounds, stomach pain, or feeling unusually dizzy or weak. There's also a second issue: beer adds to the drowsiness and slowed breathing the hydrocodone can cause, so you may feel extra sedated. It's safest to skip alcohol while taking this. Please check with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fraser AG. Pharmacokinetic interactions between alcohol and other drugs. Clin Pharmacokinet 1997;33:79-90. PubMed
Moderate

NARCOTIC DRUGS

3 of 4

Aspirin, Hydrocodone also falls under NARCOTIC DRUGS.

Concomitant use of large amounts of alcohol may decrease the metabolism of narcotic drugs.
Concomitant consumption of large amounts of alcohol can decrease the metabolism of narcotic drugs.
Severity Moderate Likelihood Possible Evidence C

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combo pill pairs hydrocodone (an opioid pain reliever) with aspirin. The concern here is mostly about the hydrocodone side. When you drink a lot of alcohol with an opioid, your body may clear the drug more slowly, so more of it sticks around. On top of that, both beer and hydrocodone calm down the nervous system, and those effects stack up.

Together that can mean heavier drowsiness, dizziness, slowed breathing, and even dangerously low breathing at higher amounts. Aspirin plus alcohol also raises the odds of stomach upset or bleeding. The risk grows with how much you drink. An occasional small beer is different from heavy drinking, but please check with your pharmacist or doctor about what's safe for you.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fraser AG. Pharmacokinetic interactions between alcohol and other drugs. Clin Pharmacokinet 1997;33:79-90. PubMed
Moderate

ASPIRIN

4 of 4
Concomitant use may increase the risk of gastrointestinal (GI) bleeding.
Concomitant use of aspirin with alcohol can increase the risk of GI bleeding. Conversely, some clinical research suggests that beer can significantly decrease the area under the curve (AUC) and maximum plasma concentration of aspirin, indicating decreased bioavailability.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combo product pairs aspirin with hydrocodone, an opioid pain reliever. The main concern with beer is the aspirin half. Alcohol and aspirin together can irritate your stomach lining and raise the chance of GI bleeding, things like stomach pain, dark or tarry stools, or even vomiting that looks like coffee grounds. There's also some lower-quality research hinting beer may lower how much aspirin you actually absorb, but the bleeding risk is the bigger real-world worry.

Don't forget the hydrocodone piece too. Adding alcohol to any opioid can deepen drowsiness, slow your breathing, and cloud your thinking. That's a serious combination. Please check with your pharmacist or doctor before drinking beer while taking this medication.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fraser AG. Pharmacokinetic interactions between alcohol and other drugs. Clin Pharmacokinet 1997;33:79-90. PubMed
  2. Odou, P., Barthelemy, C., and Robert, H. Influence of seven beverages on salicylate disposition in humans. J Clin Pharm Ther 2001;26(3):187-193. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Beer Also Interacts With Other Medications

Beer has 653 major, 272 moderate known drug interactions in our database — the Aspirin, Hydrocodone one above is among them. If you take anything else, check it against the full list below.

Major 653 Moderate 272 No known interaction 1,905 (incl. Aspirin, Hydrocodone)
Taking anything else?

Check Another of Your Medications Against Beer

Covers the 2,830 medications we’ve checked against Beer. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aspirin, Hydrocodone

This page covers Beer only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Hydrocodone page lists 363 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Danshen (major) and Gamma-hydroxybutyrate (ghb) (major).

By severity: 13 major · 308 moderate · 42 minor.

From our pharmacist’s overview on the Aspirin, Hydrocodone page

“Combining supplements with aspirin and hydrocodone (Lortab ASA, Alor 5 500) deserves real vigilance, because this medication carries two separate kinds of risk. Aspirin thins the blood, and by far the largest share of these interactions can add to that effect and raise bleeding risk.”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Hydrocodone interaction page

How much people look this up

Where Beer and Aspirin, Hydrocodone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Beer
Top 25%

#320 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Hydrocodone
Top 10%

#244 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Beer

What is Beer?

Beer
  • Social and recreational drinking
  • Relaxation
  • Heart health (popular belief)
  • Bone health (popular belief)
  • Source of antioxidants and B vitamins

Beer is an alcoholic beverage that contains some minerals, B vitamins, and plant compounds from hops and grain, but it is not a health supplement. Any possible benefits come only from light-to-moderate intake, and they are easily outweighed by the well-known harms of alcohol. The safest amount of alcohol for health is none, and beer should be avoided in pregnancy and breastfeeding.

Read the full Beer monograph & all interactions
Keep checking

Other Drugs & Beer

Browse every other medication we’ve checked against Beer — both the ones with a known interaction and the ones without. Select any drug for the full detail.

653Major
272Moderate
0Minor
1,904No known interaction
653 Major 272 Moderate 1,904 No interaction
Major

653 interactions

Showing 60 of 653 major interactions — see all 653 on the Beer page.

Moderate

272 interactions

Showing 60 of 272 moderate interactions — see all 272 on the Beer page.

No interaction 1,904 drugs checked — show the list

We also checked Beer against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,904 medications checked with no known interaction — see the full Beer list.

See the full Beer interactions page
See every supplement checked against Aspirin, Hydrocodone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Beer monograph › Uses, safety, and every drug interaction in one place Aspirin, Hydrocodone supplement interactions › Every supplement checked against Aspirin, Hydrocodone, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Beer and Aspirin, Hydrocodone Together: Common Questions

Can you take Beer with Aspirin, Hydrocodone?
This is rated a major interaction, so the combination is best avoided unless your doctor or pharmacist has specifically told you otherwise. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 4 interactions listed for Beer and Aspirin, Hydrocodone?
Aspirin, Hydrocodone belongs to more than one drug category, and Beer interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Beer and Aspirin, Hydrocodone interaction?
We rate it Major. This is a clinically significant combination that is generally best avoided, or used only under the direct supervision of your physician or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.