Drug & supplement interaction

Bifidobacterium Bifidum + Atezolizumab

Atezolizumab brand name: Tecentriq.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Bifidobacterium Bifidum and Atezolizumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Bifidobacterium Bifidum and Atezolizumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Atezolizumab and Bifidobacterium Bifidum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bifidobacterium Bifidum safety at a glance

Bifidobacterium Bi... overall Use caution Generally well tolerated in healthy people, but those with weakened immune systems should be cautious.
Pregnancy Possibly Safe When Bifidobacterium bifidum is used orally and appropriately, short-term. A combination of B. bifidum, Lactobacillus acidophilus, and Lacticaseibacillus casei... Read the full pregnancy detail
Breastfeeding Use caution Likely low risk but not well studied, so consult your doctor or pharmacist first.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Atezolizumab and Bifidobacterium Bifidum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Atezolizumab

Interactions in our licensed database are recorded against drug classes, not just single drug names. Atezolizumab is filed under 2 classifications — antineoplastics, immunosuppressants. Bifidobacterium Bifidum has documented interactions with 1 drug class — the most serious being antibiotic drugs (moderate) — and none of Atezolizumab’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bifidobacterium Bifidum Does Interact With Other Medications

Bifidobacterium Bifidum has 182 moderate known drug interactions in our database — Atezolizumab isn’t one of them. If you take anything else, check it against the full list below.

Moderate 182 No known interaction 2,648 (incl. Atezolizumab)
Taking anything else?

Check Another of Your Medications Against Bifidobacterium Bifidum

Covers the 2,830 medications we’ve checked against Bifidobacterium Bifidum. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Bifidobacterium Bifidum and Atezolizumab May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on Additional detail

    Bifidobacterium Bifidum

    “There have been cases of Bifidobacterium sepsis in critically ill patients. However, these cases are rare and none seem to be due to Bifidobacterium bifidum.”

    Bifidobacterium Bifidum · Natural Medicines adverse-effect record, reported in sepsis.

    2 sources cited
    1. 102416. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
    2. 107599. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

    Atezolizumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Atezolizumab. Read the label on DailyMed ›

  • Fever / Vomiting Additional detail

    Bifidobacterium Bifidum

    “Bloating and flatulence have been reported with probiotic use; however, these adverse effects have not been reported from ingestion of Bifidobacterium bifidum in particular. One case of vomiting and fever has been reported in a clinical study for a single child taking B. bifidum and Lactobacillus acidophilus. It is unclear if the probiotics were the causal agent.”

    Bifidobacterium Bifidum · Natural Medicines adverse-effect record, reported in flatulence.

    1 source cited
    1. 90286. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed

    Atezolizumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Atezolizumab. Read the label on DailyMed ›

Reported for Bifidobacterium Bifidum but not commonly for Atezolizumab: bloating or gas.

Effects for Atezolizumab come from the ADVERSE REACTIONS section of its FDA label; effects for Bifidobacterium Bifidum come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Bifidobacterium Bifidum in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When Bifidobacterium bifidum is used orally and appropriately, short-term. A combination of B. bifidum, Lactobacillus acidophilus, and Lacticaseibacillus casei has been used with apparent safety for 6 weeks starting at 24-28 weeks' gestation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Atezolizumab Is Prescribed For, and What Bifidobacterium Bifidum Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Atezolizumab is a prescription medicine with approved uses on its FDA label. Bifidobacterium Bifidum is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Atezolizumab is prescribed for: Tecentriq (atezolizumab) is used to treat a range of cancers in adults. It can be used alone or combined with other cancer medicines depending on the cancer type and stage. Approved uses include non-small cell lung cancer (NSCLC) — both after surgery and in metastatic (spread) disease — extensive-stage small cell lung cancer (ES-SCLC), unresectable or metastatic hepatocellular carcinoma (liver cancer), BRAF V600 mutation-positive melanoma, and muscle invasive bladder cancer after surgery. Tecentriq is also approved — as a single agent — for adult and pediatric patients aged 2 and older with unresectable or metastatic alveolar soft part sarcoma (ASPS), a rare soft tissue cancer.

Read the rest of what Atezolizumab is prescribed for

Several of these uses require tumor testing (such as PD-L1 expression or specific gene mutations) before Tecentriq is selected as treatment.

Bifidobacterium Bifidum has been studied for:

  • Cancer studied, not established Bifidobacterium Bifidum has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Bifidobacterium Bifidum for cancer

    Although there has been interest in using oral Bifidobacterium bifidum for cancer prevention or treatment, there is insufficient reliable information about the clinical effects of B. bifidum for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Atezolizumab on your own; if you are taking Bifidobacterium Bifidum for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Atezolizumab

This page covers Bifidobacterium Bifidum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atezolizumab page lists 54 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Active Hexose Correlated Compound (ahcc) (moderate), Alfalfa (moderate), American Ginseng (moderate), Andrographis (moderate) and Ashwagandha (moderate).

By severity: 52 moderate · 2 minor.

From our pharmacist’s overview on the Atezolizumab page

“Atezolizumab (Tecentriq) is cancer immunotherapy, a drug designed to release the brakes on your own immune system so it can attack tumors. That mechanism explains why nearly every one of the 54 supplements and herbs on this page made the list: 53 are flagged because they appear to stimulate immune activity, based mostly on lab and anim…”

Reviewed by 2 · Jul 18, 2026

Open the Atezolizumab interaction page

One more smart check

Taking Bifidobacterium Bifidum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3,041 real supplement products containing Bifidobacterium Bifidum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bifidobacterium Bifidum. Even though Bifidobacterium Bifidum itself has no known interaction with Atezolizumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bifidobacterium Bifidum and Atezolizumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bifidobacterium Bifidum
Top 10%

#98 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Atezolizumab
Steady interest

#2,105 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bifidobacterium Bifidum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Bifidobacterium Bifidum and Atezolizumab records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bifidobacterium Bifidum

What is Bifidobacterium Bifidum?

  • Digestive health and regularity
  • Diarrhea (including antibiotic-related)
  • Irritable bowel syndrome (IBS) symptoms
  • Supporting gut and immune balance
  • Infant gut health

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may help with certain types of diarrhea and digestive discomfort, but results vary by strain and condition. It is generally well tolerated in healthy people, but anyone who is seriously ill or has a weakened immune system should check with a doctor first.

Bifidobacterium bifidum · Bifidobacteriaceae · Live bacterial cells (probiotic culture) · Capsules, tablets, powders, sachets, chewables, and fermented dairy products; often combined with other probiotic strains

An interaction check asks whether these two react with each other — it does not ask whether Bifidobacterium Bifidum is a good idea for someone in your situation. Here is what our Bifidobacterium Bifidum record says about it on its own.

Bifidobacterium Bifidum: dosing

There is no single standardized dose of B. bifidum. Probiotic amounts are usually measured in colony-forming units (CFU), and products commonly range from millions to many billions of CFU per serving.The best amount depends on the specific product and the reason you are taking it. Take it consistently, and give it a few weeks to judge whether it helps.

From our Bifidobacterium Bifidum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bifidobacterium Bifidum monograph & all interactions
Medication

About Atezolizumab Injection

What Is Atezolizumab Injection Used For?

Brand name: Tecentriq

Tecentriq (atezolizumab) is used to treat a range of cancers in adults. It can be used alone or combined with other cancer medicines depending on the cancer type and stage. Approved uses include non-small cell lung cancer (NSCLC) — both after surgery and in metastatic (spread) disease — extensive-stage small cell lung cancer (ES-SCLC), unresectable or metastatic hepatocellular carcinoma (liver cancer), BRAF V600 mutation-positive melanoma, and muscle invasive bladder cancer after surgery.

Tecentriq is also approved — as a single agent — for adult and pediatric patients aged 2 and older with unresectable or metastatic alveolar soft part sarcoma (ASPS), a rare soft tissue cancer. Several of these uses require tumor testing (such as PD-L1 expression or specific gene mutations) before Tecentriq is selected as treatment.

See full Atezolizumab Injection drug information
Keep checking

Other Drugs & Bifidobacterium Bifidum

Browse every other medication we’ve checked against Bifidobacterium Bifidum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
182Moderate
0Minor
2,647No known interaction
182 Moderate 2,647 No interaction
Moderate

182 interactions

Showing 60 of 182 moderate interactions — see all 182 on the Bifidobacterium Bifidum page.

No interaction 2,647 drugs checked — show the list

We also checked Bifidobacterium Bifidum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,647 medications checked with no known interaction — see the full Bifidobacterium Bifidum list.

See the full Bifidobacterium Bifidum interactions page
See every supplement checked against Atezolizumab, ranked by severity
Evidence & sources

Bifidobacterium Bifidum References

The 7 references that drive our Bifidobacterium Bifidum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bifidobacterium Bifidum and Atezolizumab Together: Common Questions

Is it safe to take Bifidobacterium Bifidum with Atezolizumab?
We do not list a known interaction between Bifidobacterium Bifidum and Atezolizumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Bifidobacterium Bifidum and Atezolizumab have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Bifidobacterium Bifidum and Atezolizumab used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Bifidobacterium Bifidum in each. That is a conversation for your prescriber, especially if Atezolizumab is being adjusted to a target.
How was the Bifidobacterium Bifidum and Atezolizumab combination checked?
Interactions in our licensed database are recorded against drug classes. Atezolizumab is filed under 2 classifications, and Bifidobacterium Bifidum has documented interactions with 1 drug class — none of Atezolizumab's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Bifidobacterium Bifidum interact with any other medications?
Yes. Bifidobacterium Bifidum has 182 documented drug interactions in our database — Atezolizumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Atezolizumab interact with any supplements?
Yes. Atezolizumab has documented interactions with 54 supplements in our database — Bifidobacterium Bifidum is not one of them. The Atezolizumab interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bifidobacterium Bifidum monograph Uses, safety profile, and every drug interaction in one place Atezolizumab Injection drug information The full plain-English guide to this medication Atezolizumab supplement interactions Every supplement checked against Atezolizumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.