Medication interaction hub

What Supplements Interact with Atezolizumab?

Atezolizumab brand name: Tecentriq. Every interaction below applies to the brands too.

54 Interactions 52 Moderate 2 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Atezolizumab? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Atezolizumab against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Atezolizumab (Tecentriq) is cancer immunotherapy, a drug designed to release the brakes on your own immune system so it can attack tumors. That mechanism explains why nearly every one of the 54 supplements and herbs on this page made the list: 53 are flagged because they appear to stimulate immune activity, based mostly on lab and animal research, and could tangle with a treatment that works entirely through the immune system. None of the entries rate as major, 52 sit at moderate and 2 at minor, so for most people this is a watch-and-understand list rather than a reason for alarm. Everyday products like echinacea and ashwagandha are among those flagged.

The real issue is unpredictability. Supplements marketed as natural immune support overlap directly with what this drug does, so tell your oncology team about every capsule and powder before adding one during treatment.

— , Clinical Pharmacist · July 18, 2026

Moderate 52 Minor 2 No known interaction 1,398

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Atezolizumab: Top Interactions at a Glance

The Atezolizumab supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 54 interacting ingredients — plus 1,398 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Atezolizumab Combinations Today

The Atezolizumab + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Astragalus + Atezolizumabi

Theoretically, astragalus might interfere with immunosuppressive therapy.

Read the full interaction Moderate Likelihood Possible Larch Arabinogalactan + Atezolizumabi

Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.

Read the full interaction Moderate Likelihood Possible Cordyceps + Atezolizumabi

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.

Read the full interaction Moderate Likelihood Possible Elderberry + Atezolizumabi

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.

Read the full interaction Moderate Likelihood Possible Bee Venom + Atezolizumabi

Bee venom might stimulate immune system activity.Theoretically, bee venom might interfere with immunosuppressant therapy.

Read the full interaction Moderate Likelihood Possible Quillaia + Atezolizumabi

Theoretically, concomitant use of quillaia with immunosuppressant drugs might decrease the effectiveness of these drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Atezolizumab

All 1,452 ingredients in our database, ranked by severity — 54 with a Atezolizumab interaction on file and 1,398 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Atezolizumab?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Astragalus with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astragalus might interfere with immunosuppressive therapy.

Full Astragalus + Atezolizumab answer

Can you take Larch Arabinogalactan with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.

Full Larch Arabinogalactan + Atezolizumab answer

Can you take Cordyceps with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.

Full Cordyceps + Atezolizumab answer

Can you take Elderberry with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.

Full Elderberry + Atezolizumab answer

Can you take Bee Venom with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bee venom might stimulate immune system activity.Theoretically, bee venom might interfere with immunosuppressant therapy.

Full Bee Venom + Atezolizumab answer

Can you take Fulvic Acid with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fulvic acid might decrease the effects of immunosuppressive therapy.

Full Fulvic Acid + Atezolizumab answer

Can you take Galacto-oligosaccharides (gos) with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, GOS might reduce the effects of immunosuppressants.

Full Galacto-oligosaccharides (gos) + Atezolizumab answer

Can you take Glyconutrients with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that glyconutrients stimulate certain immune responses.

Full Glyconutrients + Atezolizumab answer

Can you take Greater Celandine with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical research suggests that taking a specific semi-synthetic derivative of the greater celandine constituent chelidonine (Uk...

Full Greater Celandine + Atezolizumab answer

Can you take Ipriflavone with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concurrent use of ipriflavone and immunosuppressant drugs might have additive effects on inhibiting immune function.

Full Ipriflavone + Atezolizumab answer

Can you take Jiaogulan with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jiaogulan might decrease the effectiveness of immunosuppressive therapy.

Full Jiaogulan + Atezolizumab answer

Can you take Kefir with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kefir might increase the risk of bacterial and yeast infections in patients taking immunosuppressants.

Full Kefir + Atezolizumab answer

Can you take Lion's Mane Mushroom with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.

Full Lion's Mane Mushroom + Atezolizumab answer

Can you take Mace with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that mace lignans can suppress immune function.

Full Mace + Atezolizumab answer

Can you take Maritime Pine with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.

Full Maritime Pine + Atezolizumab answer

Can you take Melatonin with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin might interfere with immunosuppressive therapy.

Full Melatonin + Atezolizumab answer

Can you take Neem with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem might decrease the effectiveness of immunosuppressants.

Full Neem + Atezolizumab answer

Can you take Panax Ginseng with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng use might interfere with immunosuppressive therapy.

Full Panax Ginseng + Atezolizumab answer

Can you take Picrorhiza with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Picrorhiza seems to have immunostimulating activity.

Full Picrorhiza + Atezolizumab answer

Can you take Quillaia with Atezolizumab?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of quillaia with immunosuppressant drugs might decrease the effectiveness of these drugs.

Full Quillaia + Atezolizumab answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Atezolizumab is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Atezolizumab, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Atezolizumab sits in 2 interaction categories. Open any one to see what the group means:

Immunosuppressants 53 ingredients

Medications that damp down the immune system. Supplements that stimulate immunity can work against them.

53 of the supplement ingredients on this page reach Atezolizumab through this category.

Antineoplastics 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Atezolizumab through this category.

About Atezolizumab

Atezolizumab injection is an immunotherapy drug used to treat several cancers, including non-small cell lung cancer, small cell lung cancer, liver cancer, melanoma, bladder cancer, and alveolar soft part sarcoma.

Generic name: Atezolizumab  ·  Brand name: Tecentriq.

See the full Atezolizumab Injection drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Atezolizumab

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Atezolizumab.

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Pharmacist Counseling Corner

Atezolizumab & Supplements: Common Questions

What supplements interact with Atezolizumab?
More than you might expect — 54 in total, though they are far from equal: 0 are rated major, 52 moderate, and 2 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Active Hexose Correlated Compound (ahcc), Alfalfa, American Ginseng.
Which Atezolizumab supplement interactions are the most serious?
None of the Atezolizumab supplement interactions on file are currently rated major. The most significant are the 52 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Atezolizumab?
Usually yes — most people on Atezolizumab can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Tecentriq have the same supplement interactions as Atezolizumab?
Yes — Tecentriq all contain Atezolizumab, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Atezolizumab and my other medications?
This page covers Atezolizumab against supplements and herbal ingredients. Checking Atezolizumab against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Atezolizumab Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.