Drug & supplement interaction

Bitter Almond + Atezolizumab

Atezolizumab brand name: Tecentriq.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Bitter Almond and Atezolizumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Bitter Almond and Atezolizumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Atezolizumab and Bitter Almond in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bitter Almond safety at a glance

Bitter Almond overall Avoid Bitter almond can release cyanide in the body and is considered unsafe to consume.

Pregnancy Avoid It may be poisonous and could harm the pregnancy; do not use.

Breastfeeding Likely Unsafe When used orally. There is insufficient reliable information available about the safety of bitter almond when used topically. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Atezolizumab and Bitter Almond? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Atezolizumab

Interactions in our licensed database are recorded against drug classes, not just single drug names. Atezolizumab is filed under 2 classifications — antineoplastics, immunosuppressants. Bitter Almond has documented interactions with 1 drug class — the most serious being cns depressants (moderate) — and none of Atezolizumab’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bitter Almond Does Interact With Other Medications

Bitter Almond has 248 moderate known drug interactions in our database — Atezolizumab isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Atezolizumab)

Taking anything else?

Check Another of Your Medications Against Bitter Almond

Covers the 2,830 medications we’ve checked against Bitter Almond. Pick one to open its full report.

What to actually watch for

What Bitter Almond Itself Has Been Linked To

This is not an interaction — nothing below involves Atezolizumab. It is the side-effect record for Bitter Almond on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Bitter Almond, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

A severe allergic reaction Worth acting on Additional detail

“Orally, bitter almond and its oil can be toxic due to its amygdalin content.

Most Common Adverse Effects:

Oral: Central nervous system depression with respiratory failure.

Serious Adverse Effects (Rare):

All routes of administration: Allergic reactions, including anaphylaxis.”

Bitter Almond · Natural Medicines adverse-effect record, reported in depression.
An allergic reaction Worth acting on Additional detail
“Tree nuts, which includes bitter almond, can cause allergic reactions in sensitive individuals. Due to the prevalence of this allergy in the general population, tree nuts are classified as a major food allergen in the United States.”

Bitter Almond · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).
1 source cited

105410. Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor

Everything above comes from the Natural Medicines adverse-effect record for Bitter Almond — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Atezolizumab’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Atezolizumab column appears here.

Special populations

Bitter Almond in Pregnancy & Breastfeeding

Lactation Likely Unsafe

When used orally. There is insufficient reliable information available about the safety of bitter almond when used topically.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Atezolizumab

This page covers Bitter Almond only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atezolizumab page lists 54 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Active Hexose Correlated Compound (ahcc) (moderate), Alfalfa (moderate), American Ginseng (moderate), Andrographis (moderate) and Ashwagandha (moderate).

By severity: 52 moderate · 2 minor.

From our pharmacist’s overview on the Atezolizumab page

“Atezolizumab (Tecentriq) is cancer immunotherapy, a drug designed to release the brakes on your own immune system so it can attack tumors. That mechanism explains why nearly every one of the 54 supplements and herbs on this page made the list: 53 are flagged because they appear to stimulate immune activity, based mostly on lab and anim…”

Reviewed by 2 · Jul 18, 2026

Open the Atezolizumab interaction page

One more smart check

Taking Bitter Almond as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Bitter Almond, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bitter Almond. Even though Bitter Almond itself has no known interaction with Atezolizumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bitter Almond and Atezolizumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bitter Almond

Top half

#568 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Atezolizumab

Steady interest

#2,342 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bitter Almond reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Bitter Almond and Atezolizumab records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Bitter Almond

What is Bitter Almond?

Cough suppressant
Muscle spasms (antispasmodic)
Itching and skin conditions
Flavoring agent
Sedative or 'narcotic' effects

Bitter almond is a variety of almond that contains amygdalin, a compound the body converts into cyanide, making it potentially poisonous. Because of this serious toxicity risk, bitter almond should not be eaten or used internally, and there is no reliable proof it treats any health condition. If you want almond's nutrition, choose ordinary sweet almonds instead.

Prunus dulcis var. amara · Rosaceae · Seeds (kernels) and the essential oil pressed from them · Essential oil, distilled water, flavoring extract

An interaction check asks whether these two react with each other — it does not ask whether Bitter Almond is a good idea for someone in your situation. Here is what our Bitter Almond record says about it on its own.

Bitter Almond: dosing

There is no safe, established dose of bitter almond or untreated bitter almond oil for taking by mouth, because of the cyanide poisoning risk.If you have a product that lists bitter almond as a flavoring, it should be cyanide-free and used only as directed on the label. Never try to dose raw bitter almonds or untreated oil yourself.

From our Bitter Almond monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bitter Almond monograph & all interactions

Medication

About Atezolizumab Injection

What Is Atezolizumab Injection Used For?

Brand name: Tecentriq

Tecentriq (atezolizumab) is used to treat a range of cancers in adults. It can be used alone or combined with other cancer medicines depending on the cancer type and stage. Approved uses include non-small cell lung cancer (NSCLC) — both after surgery and in metastatic (spread) disease — extensive-stage small cell lung cancer (ES-SCLC), unresectable or metastatic hepatocellular carcinoma (liver cancer), BRAF V600 mutation-positive melanoma, and muscle invasive bladder cancer after surgery.

Tecentriq is also approved — as a single agent — for adult and pediatric patients aged 2 and older with unresectable or metastatic alveolar soft part sarcoma (ASPS), a rare soft tissue cancer. Several of these uses require tumor testing (such as PD-L1 expression or specific gene mutations) before Tecentriq is selected as treatment.

See full Atezolizumab Injection drug information

Keep checking

Other Drugs & Bitter Almond

Browse every other medication we’ve checked against Bitter Almond — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

248Moderate

0Minor

2,581No known interaction

248 Moderate 2,581 No interaction

Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Bitter Almond page.

No interaction 2,581 drugs checked — show the list

We also checked Bitter Almond against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Bitter Almond list.

See the full Bitter Almond interactions page

See every supplement checked against Atezolizumab, ranked by severity

Evidence & sources

Bitter Almond References

The 3 references that drive our Bitter Almond monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bitter Almond and Atezolizumab Together: Common Questions

Is it safe to take Bitter Almond with Atezolizumab?

We do not list a known interaction between Bitter Almond and Atezolizumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Bitter Almond and Atezolizumab combination checked?

Interactions in our licensed database are recorded against drug classes. Atezolizumab is filed under 2 classifications, and Bitter Almond has documented interactions with 1 drug class — none of Atezolizumab's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Bitter Almond interact with any other medications?

Yes. Bitter Almond has 248 documented drug interactions in our database — Atezolizumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Atezolizumab interact with any supplements?

Yes. Atezolizumab has documented interactions with 54 supplements in our database — Bitter Almond is not one of them. The Atezolizumab interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bitter Almond monograph Uses, safety profile, and every drug interaction in one place Atezolizumab Injection drug information The full plain-English guide to this medication Atezolizumab supplement interactions Every supplement checked against Atezolizumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Atezolizumab and Bitter Almond?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.