Drug & supplement interaction

Bifidobacterium Breve + Ranolazine

Ranolazine brand names: Ranexa, Aspruzyo.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Bifidobacterium Breve and Ranolazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Bifidobacterium Breve and Ranolazine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ranolazine and Bifidobacterium Breve in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bifidobacterium Breve safety at a glance

Bifidobacterium Br... overall Use caution Generally well tolerated in healthy people, but caution is needed for those who are very ill or immunocompromised.
Pregnancy Use caution Probiotics are often considered low-risk, but evidence is limited, so use only with your doctor's guidance.
Breastfeeding Use caution Limited safety data exist, so check with your healthcare provider before use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ranolazine and Bifidobacterium Breve? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ranolazine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ranolazine is filed under 5 classifications — including cytochrome p450 2d6 (cyp2d6) inhibitors, qt interval-prolonging drugs, p-glycoprotein substrates. Bifidobacterium Breve has documented interactions with 1 drug class — the most serious being antibiotic drugs (moderate) — and none of Ranolazine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bifidobacterium Breve Does Interact With Other Medications

Bifidobacterium Breve has 182 moderate known drug interactions in our database — Ranolazine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 182 No known interaction 2,648 (incl. Ranolazine)
Taking anything else?

Check Another of Your Medications Against Bifidobacterium Breve

Covers the 2,830 medications we’ve checked against Bifidobacterium Breve. Pick one to open its full report.

What to actually watch for

What Bifidobacterium Breve Itself Has Been Linked To

This is not an interaction — nothing below involves Ranolazine. It is the side-effect record for Bifidobacterium Breve on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Bifidobacterium Breve, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A bowel blockage / A higher chance of infection Worth acting on Additional detail

    “There have been rare cases of Bifidobacterium bacteremia related to probiotic use in critically ill infants and adults. In addition, cases of B. breve bacteremia have occurred in preterm infants or young children using probiotics. In a review of 298 term and preterm infants who were admitted to the neonatal intensive care unit of a hospital in Japan and received B.”

    Bifidobacterium Breve · Natural Medicines adverse-effect record, reported in diabetes.

    6 sources cited
    1. 102416. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
    2. 107597. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
    3. 107599. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
    4. 107596. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
    5. 111007. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
    6. 111011. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  • Bloating or gas Additional detail

    “Bloating and flatulence have been reported with probiotic use; however, these adverse effects have not been reported from ingestion of Bifidobacterium breve in particular.”

    Bifidobacterium Breve · Natural Medicines adverse-effect record, reported in flatulence.

Everything above comes from the Natural Medicines adverse-effect record for Bifidobacterium Breve — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Ranolazine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Ranolazine column appears here.

Everything else you take

See Every Supplement That Interacts With Ranolazine

This page covers Bifidobacterium Breve only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ranolazine page lists 153 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 109 moderate · 36 minor.

From our pharmacist’s overview on the Ranolazine page

“Ranolazine (Ranexa, Aspruzyo), a medicine for chronic chest pain, depends heavily on one liver enzyme, CYP3A4, and that is where most of its supplement trouble sits. Grapefruit can push ranolazine levels up, St.”

Reviewed by 2 · Jul 18, 2026

Open the Ranolazine interaction page

One more smart check

Taking Bifidobacterium Breve as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,771 real supplement products containing Bifidobacterium Breve, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bifidobacterium Breve. Even though Bifidobacterium Breve itself has no known interaction with Ranolazine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bifidobacterium Breve and Ranolazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bifidobacterium Breve
Top 25%

#203 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ranolazine
Top 25%

#585 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bifidobacterium Breve reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Bifidobacterium Breve and Ranolazine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bifidobacterium Breve

What is Bifidobacterium Breve?

  • Digestive health and regularity
  • Infant colic and gut support
  • Diarrhea (including antibiotic-related)
  • Constipation
  • General immune and gut microbiome support

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain digestive and infant conditions, but evidence is still limited and varies by strain. It is generally well tolerated in healthy people, but anyone with a weak immune system or serious illness should check with a doctor or pharmacist first.

Bifidobacterium breve · Bifidobacteriaceae · Live bacterial cells (probiotic strain) · Capsules, powders, sachets, chewables, drops, and fortified foods or drinks

An interaction check asks whether these two react with each other — it does not ask whether Bifidobacterium Breve is a good idea for someone in your situation. Here is what our Bifidobacterium Breve record says about it on its own.

Bifidobacterium Breve: dosing

There is no single standard dose of Bifidobacterium breve. Probiotic amounts are usually measured in colony-forming units (CFU), and products vary widely in their strain and strength.The best approach is to follow the directions on the product label, since dosing was often based on the specific strain studied.

From our Bifidobacterium Breve monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bifidobacterium Breve monograph & all interactions
Medication

About Ranolazine

What Is Ranolazine Used For?

Brand names: Ranexa, Aspruzyo

Ranolazine treats chronic angina — the recurring chest pain or pressure that happens when the heart isn't getting enough blood and oxygen. It is used when other angina medicines aren't enough on their own.

Both the extended-release tablet (sold as Ranexa and generic ranolazine) and the oral powder form (sold as Aspruzyo Sprinkle) are approved for this use. Ranolazine can be combined with other heart medicines such as beta-blockers, nitrates, calcium channel blockers, anti-platelet drugs, statins, ACE inhibitors, and angiotensin receptor blockers.

Most-Reported Side Effects for Ranolazine

From FAERS, the FDA’s public side-effect reporting system (10,376 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Myocardial infarction 646 reports
Chest pain 614 reports
Angina pectoris 595 reports
Stent placement 582 reports
Dyspnea 439 reports
See full Ranolazine drug information
Keep checking

Other Drugs & Bifidobacterium Breve

Browse every other medication we’ve checked against Bifidobacterium Breve — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
182Moderate
0Minor
2,647No known interaction
182 Moderate 2,647 No interaction
Moderate

182 interactions

Showing 60 of 182 moderate interactions — see all 182 on the Bifidobacterium Breve page.

No interaction 2,647 drugs checked — show the list

We also checked Bifidobacterium Breve against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,647 medications checked with no known interaction — see the full Bifidobacterium Breve list.

See the full Bifidobacterium Breve interactions page
See every supplement checked against Ranolazine, ranked by severity
Evidence & sources

Bifidobacterium Breve References

The 9 references that drive our Bifidobacterium Breve monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bifidobacterium Breve and Ranolazine Together: Common Questions

Is it safe to take Bifidobacterium Breve with Ranolazine?
We do not list a known interaction between Bifidobacterium Breve and Ranolazine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Bifidobacterium Breve and Ranolazine combination checked?
Interactions in our licensed database are recorded against drug classes. Ranolazine is filed under 5 classifications, and Bifidobacterium Breve has documented interactions with 1 drug class — none of Ranolazine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Bifidobacterium Breve interact with any other medications?
Yes. Bifidobacterium Breve has 182 documented drug interactions in our database — Ranolazine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ranolazine interact with any supplements?
Yes. Ranolazine has documented interactions with 153 supplements in our database — Bifidobacterium Breve is not one of them. The Ranolazine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bifidobacterium Breve monograph Uses, safety profile, and every drug interaction in one place Ranolazine drug information The full plain-English guide to this medication Ranolazine supplement interactions Every supplement checked against Ranolazine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ranolazine and Bifidobacterium Breve?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.