Drug & supplement interaction

Black Mulberry + Benzocaine

Benzocaine brand names: Bi-Zets, Hurricaine, Topex, Orajel.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Black Mulberry and Benzocaine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share

Facebook Post Reddit Email

On this page

Interaction report

Black Mulberry and Benzocaine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Benzocaine and Black Mulberry in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Black Mulberry safety at a glance

Black Mulberry overall Use caution The fruit is safe as food, but concentrated supplement doses are less studied.

Pregnancy Use caution Eating the fruit as food is likely fine, but avoid concentrated extracts unless your doctor approves.

Breastfeeding Use caution Fruit as food is likely fine, but there is little safety data on supplement doses.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Benzocaine and Black Mulberry? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Benzocaine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Benzocaine is filed under a single classification — topical drugs. Black Mulberry has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and midazolam (versed) (moderate) — and none of Benzocaine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Black Mulberry Does Interact With Other Medications

Black Mulberry has 87 moderate known drug interactions in our database — Benzocaine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 87 No known interaction 2,743 (incl. Benzocaine)

Taking anything else?

Check Another of Your Medications Against Black Mulberry

Covers the 2,830 medications we’ve checked against Black Mulberry. Pick one to open its full report.

What to actually watch for

What Black Mulberry Itself Has Been Linked To

This is not an interaction — nothing below involves Benzocaine. It is the side-effect record for Black Mulberry on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Black Mulberry, this list is the first place to look.

A skin rash Additional detail
“Topically, black mulberry leaf may cause contact dermatitis. A case of lichenoid contact dermatitis was reported in a 68-year-old male who came into contact with black mulberry leaves while picking black mulberries.”

Black Mulberry · Natural Medicines adverse-effect record, reported in dermatitis.
1 source cited

105799. Navarro-Triviño FJ, Jadczak P, Llamas-Molina JM, Ruiz-Villaverde R. Lichenoid contact dermatitis caused by Morus nigra L. Contact Dermatitis 2021;84(6):484-486.

Everything above comes from the Natural Medicines adverse-effect record for Black Mulberry — expand a row for the licensed statement it rests on. We haven’t matched Benzocaine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Benzocaine.

Everything else you take

See Every Supplement That Interacts With Benzocaine

This page covers Black Mulberry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Benzocaine page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Benzocaine page

“Benzocaine is a surface numbing agent, the ingredient in Orajel, Hurricaine, and similar gels for toothaches and minor skin pain, and its supplement interaction list is short and manageable. Only three ingredients are on file, none rated major, and all three involve products applied to the same skin or mouth area rather than anything y…”

Reviewed by 2 · Jul 18, 2026

Open the Benzocaine interaction page

How much people look this up

Where Black Mulberry and Benzocaine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Mulberry

Steady interest

#738 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Benzocaine

Steady interest

#2,395 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Mulberry reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Black Mulberry and Benzocaine records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Black Mulberry

What is Black Mulberry?

General antioxidant support
Blood sugar support
Cholesterol and heart health
Digestive health
Cold and sore throat remedies (traditional)

Black mulberry is a nutritious fruit rich in antioxidants and vitamins, and it is generally safe to enjoy as a food. Some early research on its leaf and fruit extracts hints at benefits for blood sugar and cholesterol, but the evidence is still limited. Talk with your pharmacist or doctor before using concentrated extracts, especially if you have a health condition.

Morus nigra · Moraceae · Fruit (berries), leaves, and sometimes root bark · Fresh or dried fruit, juice, jam, tea, powder, and capsules or extracts

An interaction check asks whether these two react with each other — it does not ask whether Black Mulberry is a good idea for someone in your situation. Here is what our Black Mulberry record says about it on its own.

Black Mulberry: dosing

There is no official standardized dose for black mulberry supplements. The amount in products varies widely depending on whether the fruit, leaf, or an extract is used.If you use a commercial product, follow the directions on the label and do not take more than recommended. Eating the fresh or dried fruit as part of a normal diet does not require special dosing.

From our Black Mulberry monograph — the full record covers uses, side effects and every documented interaction.

Read the full Black Mulberry monograph & all interactions

Medication

About Benzocaine

Most-Reported Side Effects for Benzocaine

From FAERS, the FDA’s public side-effect reporting system (1,529 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Methaemoglobinaemia 176 reports

Dyspnea 107 reports

Nausea 86 reports

Drug hypersensitivity 75 reports

Asthenia 74 reports

Keep checking

Other Drugs & Black Mulberry

Browse every other medication we’ve checked against Black Mulberry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

87Moderate

0Minor

2,742No known interaction

87 Moderate 2,742 No interaction

Moderate

87 interactions

Showing 60 of 87 moderate interactions — see all 87 on the Black Mulberry page.

No interaction 2,742 drugs checked — show the list

We also checked Black Mulberry against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,742 medications checked with no known interaction — see the full Black Mulberry list.

See the full Black Mulberry interactions page

See every supplement checked against Benzocaine, ranked by severity

Evidence & sources

Black Mulberry References

The 5 references that drive our Black Mulberry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Kim, H., Yoon, Y. J., Shon, J. H., Cha, I. J., Shin, J. G., and Liu, K. H. Inhibitory effects of fruit juices on CYP3A activity. Drug Metab Dispos. 2006;34(4):521-523. PubMed
Xu LJ, Yu MH, Huang CY, et al. Isoprenylated flavonoids from Morus nigra and their PPAR ? agonistic activities. Fitoterapia 2018;127:109-14. PubMed
Momeni H, Salehi A, Absalan A, Akbari M. Hydro-alcoholic extract of Morus nigra reduces fasting blood glucose and HbA1c% in diabetic patients, probably via competitive and allosteric interaction with alpha-glucosidase enzyme; a clinical trial and in silic
Navarro-Triviño FJ, Jadczak P, Llamas-Molina JM, Ruiz-Villaverde R. Lichenoid contact dermatitis caused by Morus nigra L. Contact Dermatitis 2021;84(6):484-486.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Black Mulberry and Benzocaine Together: Common Questions

Is it safe to take Black Mulberry with Benzocaine?

We do not list a known interaction between Black Mulberry and Benzocaine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Black Mulberry and Benzocaine combination checked?

Interactions in our licensed database are recorded against drug classes. Benzocaine is filed under 1 classification, and Black Mulberry has documented interactions with 2 drug classes — none of Benzocaine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Black Mulberry interact with any other medications?

Yes. Black Mulberry has 87 documented drug interactions in our database — Benzocaine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Benzocaine interact with any supplements?

Yes. Benzocaine has documented interactions with 3 supplements in our database — Black Mulberry is not one of them. The Benzocaine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Black Mulberry monograph Uses, safety profile, and every drug interaction in one place Benzocaine supplement interactions Every supplement checked against Benzocaine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Benzocaine and Black Mulberry?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.