Drug & supplement interaction

Boneset + Diethylstilbestrol Diphosphate

Diethylstilbestrol Diphosphate brand name: Stilphostrol.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Boneset and Diethylstilbestrol Diphosphate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Boneset and Diethylstilbestrol Diphosphate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diethylstilbestrol Diphosphate and Boneset in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Boneset safety at a glance

Boneset overall Use caution Limited safety data and possible liver-toxic alkaloids mean it should be used carefully and short-term, if at all.

Pregnancy Possibly Unsafe When used orally. Hepatotoxic PAs are common in this genus of plants; however, the alkaloids in boneset have not been adequately characterized to determine thei... Read the full pregnancy detail

Breastfeeding Possibly Unsafe When used orally. Hepatotoxic PAs are common in this genus of plants; however, the alkaloids in boneset have not been adequately characterized to determine thei... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diethylstilbestrol Diphosphate and Boneset? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Diethylstilbestrol Diphosphate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Diethylstilbestrol Diphosphate is filed under a single classification — oral drugs. Boneset has documented interactions with 1 drug class — the most serious being cytochrome p450 3a4 (cyp3a4) inducers (moderate) — and none of Diethylstilbestrol Diphosphate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Boneset Does Interact With Other Medications

Boneset has 87 moderate known drug interactions in our database — Diethylstilbestrol Diphosphate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 87 No known interaction 2,743 (incl. Diethylstilbestrol Diphosphate)

Taking anything else?

Check Another of Your Medications Against Boneset

Covers the 2,830 medications we’ve checked against Boneset. Pick one to open its full report.

What to actually watch for

What Boneset Itself Has Been Linked To

This is not an interaction — nothing below involves Diethylstilbestrol Diphosphate. It is the side-effect record for Boneset on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Boneset, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

Liver problems Worth acting on Additional detail
“Orally, boneset is reported to cause nausea and severe diarrhea and vomiting. Additionally, other plants in the Eupatorium genus contain the hepatotoxic pyrrolizidine alkaloids (PAs). However, the alkaloids in boneset have not been adequately characterized to determine their toxic potential. Liver toxicity and liver damage may be possible in high doses.”

Boneset · Natural Medicines adverse-effect record, reported in diarrhea.
2 sources cited

12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.

102557. Colegate SM, Upton R, Gardner DR, Panter KE, Betz JM. Potentially toxic pyrrolizidine alkaloids in Eupatorium perfoliatum and three related species. Implications for herbal use as boneset. Phytochem Anal. 2018;29(6):613-626.
Diarrhea / Vomiting / Nausea Additional detail
“Orally, boneset has been reported to cause nausea and severe diarrhea and vomiting.”

Boneset · Natural Medicines adverse-effect record, reported in diarrhea.
1 source cited

12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.

Everything above comes from the Natural Medicines adverse-effect record for Boneset — expand a row for the licensed statement it rests on. We haven’t matched Diethylstilbestrol Diphosphate to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Diethylstilbestrol Diphosphate.

Special populations

Boneset in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. Hepatotoxic PAs are common in this genus of plants; however, the alkaloids in boneset have not been adequately characterized to determine their toxic potential. Hepatotoxic PAs might be teratogenic; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Diethylstilbestrol Diphosphate

This page covers Boneset only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diethylstilbestrol Diphosphate page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Diethylstilbestrol Diphosphate page

“Diethylstilbestrol diphosphate (Stilphostrol) is a synthetic estrogen used against advanced prostate cancer, and I read its interaction list with real seriousness, because all 17 entries threaten the same thing, how much of the drug actually gets absorbed. Fiber, gum, and mucilage supplements such as psyllium and glucomannan can bind t…”

Reviewed by 2 · Jul 18, 2026

Open the Diethylstilbestrol Diphosphate interaction page

One more smart check

Taking Boneset as Part of a Dietary Supplement Product? Check It for Interactions

We hold 118 real supplement products containing Boneset, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Boneset. Even though Boneset itself has no known interaction with Diethylstilbestrol Diphosphate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Boneset and Diethylstilbestrol Diphosphate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Boneset

Top half

#364 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Diethylstilbestrol Diphosphate

Top 25%

#478 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Boneset reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Boneset and Diethylstilbestrol Diphosphate records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Boneset

What is Boneset?

Colds and flu
Fever
Body aches
Congestion
Immune support

Boneset is a traditional North American herb long used in teas for fevers, colds, and flu, but modern human studies are very limited. It contains compounds (pyrrolizidine alkaloids) that may harm the liver, so it should be used cautiously and avoided during pregnancy and breastfeeding.

Eupatorium perfoliatum · Asteraceae · Dried above-ground parts (leaves and flowering tops) · Tea, tincture, capsules, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Boneset is a good idea for someone in your situation. Here is what our Boneset record says about it on its own.

Boneset: dosing

There is no well-established, standardized dose for boneset. Traditional preparations were usually made as a hot tea from the dried herb, but reliable modern dosing guidelines are not available.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Boneset monograph — the full record covers uses, side effects and every documented interaction.

Read the full Boneset monograph & all interactions

Keep checking

Other Drugs & Boneset

Browse every other medication we’ve checked against Boneset — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

87Moderate

0Minor

2,742No known interaction

87 Moderate 2,742 No interaction

Moderate

87 interactions

Showing 60 of 87 moderate interactions — see all 87 on the Boneset page.

No interaction 2,742 drugs checked — show the list

We also checked Boneset against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,742 medications checked with no known interaction — see the full Boneset list.

See the full Boneset interactions page

See every supplement checked against Diethylstilbestrol Diphosphate, ranked by severity

Evidence & sources

Boneset References

The 5 references that drive our Boneset monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
Gassinger, C. A., Wunstel, G., and Netter, P. [A controlled clinical trial for testing the efficacy of the homeopathic drug eupatorium perfoliatum D2 inthe treatment of common cold (author's transl)]. Arzneimittelforschung. 1981;31(4):732-736.
Colegate SM, Upton R, Gardner DR, Panter KE, Betz JM. Potentially toxic pyrrolizidine alkaloids in Eupatorium perfoliatum and three related species. Implications for herbal use as boneset. Phytochem Anal. 2018;29(6):613-626.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Boneset and Diethylstilbestrol Diphosphate Together: Common Questions

Is it safe to take Boneset with Diethylstilbestrol Diphosphate?

We do not list a known interaction between Boneset and Diethylstilbestrol Diphosphate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Boneset and Diethylstilbestrol Diphosphate combination checked?

Interactions in our licensed database are recorded against drug classes. Diethylstilbestrol Diphosphate is filed under 1 classification, and Boneset has documented interactions with 1 drug class — none of Diethylstilbestrol Diphosphate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Boneset interact with any other medications?

Yes. Boneset has 87 documented drug interactions in our database — Diethylstilbestrol Diphosphate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Diethylstilbestrol Diphosphate interact with any supplements?

Yes. Diethylstilbestrol Diphosphate has documented interactions with 17 supplements in our database — Boneset is not one of them. The Diethylstilbestrol Diphosphate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Boneset monograph Uses, safety profile, and every drug interaction in one place Diethylstilbestrol Diphosphate supplement interactions Every supplement checked against Diethylstilbestrol Diphosphate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diethylstilbestrol Diphosphate and Boneset?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.