Bugleweed + Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate
Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate brand name: Xywav.
We found no known interaction between Bugleweed and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate states a food rule worth keeping to.
Bugleweed and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate and Bugleweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Bugleweed safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate
Interactions in our licensed database are recorded against drug classes, not just single drug names. Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate is filed under 2 classifications — seizure threshold lowering drugs, oral drugs. Bugleweed has documented interactions with 1 drug class — the most serious being thyroid hormone (moderate) — and none of Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Bugleweed Does Interact With Other Medications
Bugleweed has 16 moderate known drug interactions in our database — Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Bugleweed
We haven’t checked that one against Bugleweed yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Bugleweed. Pick one to open its full report.
Bugleweed in Pregnancy & Breastfeeding
When used orally. Bugleweed has anti-gonadotropic and anti-thyrotropic activity; avoid using.
When used orally because it might have anti-prolactin activity; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate Products Have a Food Rule — Bugleweed Should Not Break It
At least one FDA label for a product containing Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate says to take it with food. If you take Bugleweed on an empty stomach out of habit, keep them separate — and take Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Important Administration Information • Administer XYWAV at least 2 hours after eating ( 2.4 ).
From the Dosage and Administration section of the FDA label we read for Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate
This page covers Bugleweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate page lists 23 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Biofeedback (moderate), Coffee Charcoal (moderate), Dendrobium (moderate) and European Mandrake (moderate).
By severity: 1 major · 13 moderate · 9 minor.
From our pharmacist’s overview on the Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate page
“Xywav combines calcium, magnesium, potassium, and sodium oxybates to treat cataplexy and daytime sleepiness in narcolepsy, and because each nightly dose is measured and timed with real precision, this list deserves genuine attention rather than a quick skim. The one major entry, activated charcoal, can bind the drug in the gut and shar…”
Reviewed by 2 · Jul 18, 2026
Open the Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate interaction page
Taking Bugleweed as Part of a Dietary Supplement Product? Check It for Interactions
We hold 29 real supplement products containing Bugleweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bugleweed. Even though Bugleweed itself has no known interaction with Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Bugleweed and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#479 of 1,452 supplements looked up here in the last 7 days
#1,727 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bugleweed reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Bugleweed and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Bugleweed
What is Bugleweed?
- Mild overactive thyroid symptoms
- Heart palpitations and rapid heartbeat
- Anxiety and restlessness
- Breast pain (mastalgia)
- Premenstrual symptoms
Bugleweed is a traditional herb most often used for mild overactive thyroid symptoms and the rapid heartbeat that can come with it, but high-quality human evidence is very limited. Because it may affect thyroid hormones, it should not be used without medical supervision, and it must be avoided in pregnancy and breastfeeding.
Lycopus virginicus · Lamiaceae · Aerial parts (leaves, stems, and flowering tops) · Tea, tincture, liquid extract, capsules, dried herb
An interaction check asks whether these two react with each other — it does not ask whether Bugleweed is a good idea for someone in your situation. Here is what our Bugleweed record says about it on its own.
Bugleweed: dosing
There is no well-established standardized dose for bugleweed. Do not exceed the recommended amount, and do not use it long-term without medical supervision.
From our Bugleweed monograph — the full record covers uses, side effects and every documented interaction.
About Calcium, Magnesium, Potassium, and Sodium Oxybate
What Is Calcium, Magnesium, Potassium, and Sodium Oxybate Used For?
Brand name: Xywav
Xywav (calcium, magnesium, potassium, and sodium oxybate) is approved to treat two symptoms of narcolepsy — cataplexy (sudden muscle weakness triggered by emotion) and excessive daytime sleepiness (EDS) — in patients 7 years of age and older.
Xywav is also approved to treat idiopathic hypersomnia (IH) — a sleep disorder that causes excessive sleepiness even after long periods of sleep — in adults.
Other Drugs & Bugleweed
Browse every other medication we’ve checked against Bugleweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
16 interactions
- Levothyroxine ›
- Conjugated Estrogens ›
- Testosterone Undecanoate ›
- Levothyroxine Sodium ›
- Liotrix ›
- Desiccated Thyroid Extract ›
- Desiccated Thyroid Extract (prescription Drug) ›
- Menotropins ›
- Dextrothyroxine ›
- Human Chorionic Gonadotropin (hcg) ›
- Liothyronine ›
- Ospemifene ›
- Thyroglobulin ›
- Thyroid Hormone ›
- Levothyroxine, Liothyronine ›
- Liotrix, T4/t3 ›
No interaction 2,813 drugs checked — show the list
We also checked Bugleweed against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Tadalafil ›
- Clopidogrel ›
- Abemaciclib ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Ibuprofen ›
- Methamphetamine ›
- Tirzepatide ›
- Semaglutide ›
- Warfarin Sodium ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Bendamustine ›
- Amitriptyline ›
- Acyclovir ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Lamotrigine ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Gabapentin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Amlodipine Besylate ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,813 medications checked with no known interaction — see the full Bugleweed list.
Bugleweed References
The 4 references that drive our Bugleweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Bugleweed and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate Together: Common Questions
Is it safe to take Bugleweed with Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate?
Should I take Bugleweed and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate at the same time of day?
How was the Bugleweed and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate combination checked?
Does Bugleweed interact with any other medications?
Does Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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