Bugleweed - Sinemet (Carbidopa, Levodopa) Interaction
Herbal: Bugleweed
Also Known As: Lycopus americanus, Archangle, Ashangee, Bugle Weed, Green Wolf's Foot, Gypsy Weed, Gypsywort, Hoarhound, Lycope, Lycope d'Europe, Lycopi Herba, Lycopus Europea, Paul's Betony, Sweet Bugle, Virginia Water Horehound, Water Bugle, Water Hoarhound, Water Horehound, Wolfstrapp
Drug: Carbidopa, Levodopa
Brand names:
Sinemet CR, Sinemet, Rytary, Dhivy
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 22, 2025
Interaction Details
There were no interactions found between Carbidopa, Levodopa and Bugleweed. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Bugleweed Overview
Lycopus americanus, commonly known as American bugleweed or water horehound, is a native herbaceous perennial plant found in North America. It features square stems, opposite leaves, and clusters of tiny white to pale pink flowers, often growing in wetland areas. This plant has a history of traditional medicinal use, with some preparations believed to have potential benefits in addressing conditions such as thyroid disorders and anxiety. Additionally, Lycopus americanus is known for its ecological role in wetland ecosystems, providing habitat and support for various wildlife.
Carbidopa, Levodopa Overview
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The combination of levodopa and carbidopa is used to treat the symptoms of Parkinson's disease and Parkinson's-like symptoms that may develop after encephalitis (swelling of the brain) or injury to the nervous system caused by carbon monoxide poisoning or manganese poisoning. Parkinson's symptoms, including tremors (shaking), stiffness, and slowness of movement, are caused by a lack of dopamine, a natural substance usually found in the brain. Levodopa is in a class of medications called central nervous system agents. It works by being converted to dopamine in the brain. Carbidopa is in a class of medications called decarboxylase inhibitors. It works by preventing levodopa from being broken down before it reaches the brain. This allows for a lower dose of levodopa, which causes less nausea and vomiting.
Bugleweed - More Interactions
Bugleweed interacts with 16 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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