Drug & supplement interaction

Bugleweed + Mefloquine

Mefloquine brand name: Lariam.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Bugleweed and Mefloquine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Mefloquine states a food rule worth keeping to.

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Interaction report

Bugleweed and Mefloquine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mefloquine and Bugleweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bugleweed safety at a glance

Bugleweed overall Use caution May affect thyroid function, so use only under the guidance of a healthcare provider.
Pregnancy Likely Unsafe When used orally. Bugleweed has anti-gonadotropic and anti-thyrotropic activity; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally because it might have anti-prolactin activity; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mefloquine and Bugleweed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Mefloquine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Mefloquine is filed under 2 classifications — seizure threshold lowering drugs, oral drugs. Bugleweed has documented interactions with 1 drug class — the most serious being thyroid hormone (moderate) — and none of Mefloquine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bugleweed Does Interact With Other Medications

Bugleweed has 16 moderate known drug interactions in our database — Mefloquine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 16 No known interaction 2,814 (incl. Mefloquine)
Taking anything else?

Check Another of Your Medications Against Bugleweed

Covers the 2,830 medications we’ve checked against Bugleweed. Pick one to open its full report.

What to actually watch for

What Mefloquine’s Own FDA Label Lists

This is not an interaction — none of it involves Bugleweed. These are the most notable effects listed in the ADVERSE REACTIONS section of Mefloquine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Thoughts of self-harm Worth acting on
  • Muscle weakness Worth acting on
  • Memory problems Worth acting on
  • Unsteadiness Worth acting on
  • A slow heartbeat Worth acting on
  • Hallucinations Worth acting on
  • Fainting Worth acting on
  • An irregular heartbeat Worth acting on
  • Confusion Worth acting on
  • A severe skin reaction Worth acting on

Showing the 10 most notable of 51 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Mefloquine. Read the label on DailyMed › Bugleweed’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Bugleweed side to compare — that is a limit of the record, not a statement that Bugleweed has no side effects.

Special populations

Bugleweed in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Bugleweed has anti-gonadotropic and anti-thyrotropic activity; avoid using.

Lactation Possibly Unsafe

When used orally because it might have anti-prolactin activity; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Mefloquine Products Have a Food Rule — Bugleweed Should Not Break It

At least one FDA label for a product containing Mefloquine says to take it on an empty stomach. Most supplements — Bugleweed included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Mefloquine on its own and move Bugleweed to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Mefloquine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

The drug should not be taken on an empty stomach and should be administered with at least 8 oz (240 mL) of water.

From the Dosage and Administration section of the FDA label we read for Mefloquine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Mefloquine

This page covers Bugleweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mefloquine page lists 23 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Biofeedback (moderate), Coffee Charcoal (moderate), Dendrobium (moderate) and European Mandrake (moderate).

By severity: 1 major · 13 moderate · 9 minor.

From our pharmacist’s overview on the Mefloquine page

“Mefloquine (Lariam) prevents and treats malaria and carries its own well-known warnings about seizures and psychiatric effects, so I take this interaction list more seriously than most. Six of the 23 supplements on file, including ginkgo and melatonin, may lower the seizure threshold, a poor match for a drug with mefloquine's neurologi…”

Reviewed by 2 · Jul 18, 2026

Open the Mefloquine interaction page

One more smart check

Taking Bugleweed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 29 real supplement products containing Bugleweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bugleweed. Even though Bugleweed itself has no known interaction with Mefloquine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bugleweed and Mefloquine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bugleweed
Steady interest

#847 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mefloquine
Steady interest

#1,488 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bugleweed reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Bugleweed and Mefloquine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bugleweed

What is Bugleweed?

Bugleweed
  • Mild overactive thyroid symptoms
  • Heart palpitations and rapid heartbeat
  • Anxiety and restlessness
  • Breast pain (mastalgia)
  • Premenstrual symptoms

Bugleweed is a traditional herb most often used for mild overactive thyroid symptoms and the rapid heartbeat that can come with it, but high-quality human evidence is very limited. Because it may affect thyroid hormones, it should not be used without medical supervision, and it must be avoided in pregnancy and breastfeeding.

Lycopus virginicus · Lamiaceae · Aerial parts (leaves, stems, and flowering tops) · Tea, tincture, liquid extract, capsules, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Bugleweed is a good idea for someone in your situation. Here is what our Bugleweed record says about it on its own.

Bugleweed: dosing

There is no well-established standardized dose for bugleweed. Do not exceed the recommended amount, and do not use it long-term without medical supervision.

From our Bugleweed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bugleweed monograph & all interactions
Medication

About Mefloquine

What Is Mefloquine Used For?

Brand name: Lariam

Mefloquine Hydrochloride tablets are used to treat mild to moderate malaria caused by P. falciparum (including strains resistant to chloroquine) or P. vivax. They are also used to prevent malaria caused by these two parasite species, including chloroquine-resistant strains of P. falciparum, in people traveling to or living in areas where malaria is common.

Important note: Mefloquine does not eliminate the liver-stage parasites of P. vivax, so patients treated for P. vivax malaria will need a follow-up medication (such as primaquine) to prevent the infection from coming back. For life-threatening or severe malaria, an intravenous antimalarial is used first; mefloquine may then be given to complete the course.

See full Mefloquine drug information
Keep checking

Other Drugs & Bugleweed

Browse every other medication we’ve checked against Bugleweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
16Moderate
0Minor
2,813No known interaction
16 Moderate 2,813 No interaction
Moderate

16 interactions

No interaction 2,813 drugs checked — show the list

We also checked Bugleweed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,813 medications checked with no known interaction — see the full Bugleweed list.

See the full Bugleweed interactions page
See every supplement checked against Mefloquine, ranked by severity
Evidence & sources

Bugleweed References

The 4 references that drive our Bugleweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bugleweed and Mefloquine Together: Common Questions

Is it safe to take Bugleweed with Mefloquine?
We do not list a known interaction between Bugleweed and Mefloquine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Bugleweed and Mefloquine at the same time of day?
At least one FDA label for a product containing Mefloquine says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Mefloquine on its own and move Bugleweed to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Bugleweed and Mefloquine combination checked?
Interactions in our licensed database are recorded against drug classes. Mefloquine is filed under 2 classifications, and Bugleweed has documented interactions with 1 drug class — none of Mefloquine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Bugleweed interact with any other medications?
Yes. Bugleweed has 16 documented drug interactions in our database — Mefloquine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Mefloquine interact with any supplements?
Yes. Mefloquine has documented interactions with 23 supplements in our database — Bugleweed is not one of them. The Mefloquine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bugleweed monograph Uses, safety profile, and every drug interaction in one place Mefloquine drug information The full plain-English guide to this medication Mefloquine supplement interactions Every supplement checked against Mefloquine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mefloquine and Bugleweed?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.