Drug & supplement interaction

Butea Superba + Imipramine

Imipramine brand names: Tofranil, Tofranil PM.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Butea Superba and Imipramine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Butea Superba and Imipramine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Imipramine and Butea Superba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Butea Superba safety at a glance

Butea Superba overall Use caution Limited safety data exist, and quality of products varies widely.
Pregnancy Avoid No reliable safety data; avoid during pregnancy.
Breastfeeding Avoid No reliable safety data; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Imipramine and Butea Superba? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Imipramine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Imipramine is filed under 15 classifications — including tricyclic antidepressants (tcas), antidepressant drugs, cytochrome p450 2c19 (cyp2c19) substrates. Butea Superba has documented interactions with 1 drug class — the most serious being phosphodiesterase-5 inhibitors (moderate) — and none of Imipramine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Butea Superba Does Interact With Other Medications

Butea Superba has 7 moderate known drug interactions in our database — Imipramine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 7 No known interaction 2,823 (incl. Imipramine)
Taking anything else?

Check Another of Your Medications Against Butea Superba

Covers the 2,830 medications we’ve checked against Butea Superba. Pick one to open its full report.

What to actually watch for

What Imipramine’s Own FDA Label Lists

This is not an interaction — none of it involves Butea Superba. These are the most notable effects listed in the ADVERSE REACTIONS section of Imipramine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Mania or an unusually elevated mood Worth acting on
  • Dependence or withdrawal symptoms Worth acting on
  • A bowel blockage Worth acting on
  • Trouble passing urine Worth acting on
  • Low sodium Worth acting on
  • Unsteadiness Worth acting on
  • A heart attack Worth acting on
  • Hallucinations Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Heart failure Worth acting on

Showing the 10 most notable of 52 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Imipramine. Read the label on DailyMed › Butea Superba’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Butea Superba side to compare — that is a limit of the record, not a statement that Butea Superba has no side effects.

From our Q&A

Questions About Butea Superba or Imipramine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Butea Superba or Imipramine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Imipramine

This page covers Butea Superba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Imipramine page lists 254 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 11 major · 190 moderate · 53 minor.

From our pharmacist’s overview on the Imipramine page

“Imipramine (Tofranil) is an older tricyclic antidepressant, and the supplements on this page deserve real scrutiny before you add one. Most of the list acts on the liver enzymes that process the drug, so an ingredient can quietly raise or lower imipramine levels: grapefruit pushes them up, while St.”

Reviewed by 2 · Jul 18, 2026

Open the Imipramine interaction page

One more smart check

Taking Butea Superba as Part of a Dietary Supplement Product? Check It for Interactions

We hold 23 real supplement products containing Butea Superba, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Butea Superba. Even though Butea Superba itself has no known interaction with Imipramine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Butea Superba and Imipramine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Butea Superba
Top half

#670 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Imipramine
Steady interest

#1,843 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Butea Superba reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Butea Superba and Imipramine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Butea Superba

What is Butea Superba?

Butea Superba
  • Erectile dysfunction
  • Low libido
  • Male sexual performance
  • General vitality and energy
  • Traditional tonic

Butea superba is a Thai herb traditionally used to support male sexual health, but the human evidence is very limited and mostly small or low-quality. Its safety has not been well studied, so caution is advised, and you should talk with a pharmacist or doctor before trying it—especially if you have a medical condition or take other medicines.

Butea superba · Fabaceae · Root (tuber) · Capsules, tablets, powder, tinctures, topical gels

An interaction check asks whether these two react with each other — it does not ask whether Butea Superba is a good idea for someone in your situation. Here is what our Butea Superba record says about it on its own.

Butea Superba: dosing

There is no well-established or standardized dose for Butea superba. Studies have used different amounts and preparations, so it is hard to recommend a specific, reliable dose.If you choose to use it, follow the directions on the product label and do not exceed them.

From our Butea Superba monograph — the full record covers uses, side effects and every documented interaction.

Read the full Butea Superba monograph & all interactions
Medication

About Imipramine

What Is Imipramine Used For?

Brand names: Tofranil, Tofranil PM

Imipramine is used to relieve symptoms of depression. Both Imipramine Hydrochloride tablets and Imipramine Pamoate capsules are approved for this use. Endogenous depression — the kind that seems to arise from within rather than a clear outside cause — tends to respond especially well. It may take one to three weeks before you notice the full benefit.

Imipramine Hydrochloride tablets are also approved as a short-term, add-on treatment to help reduce nighttime bedwetting (nocturnal enuresis) in children aged 6 and older, after a doctor has ruled out physical causes.

See full Imipramine drug information
Keep checking

Other Drugs & Butea Superba

Browse every other medication we’ve checked against Butea Superba — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
7Moderate
0Minor
2,822No known interaction
7 Moderate 2,822 No interaction
Moderate

7 interactions

No interaction 2,822 drugs checked — show the list

We also checked Butea Superba against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,822 medications checked with no known interaction — see the full Butea Superba list.

See the full Butea Superba interactions page
See every supplement checked against Imipramine, ranked by severity
Evidence & sources

Butea Superba References

The 2 references that drive our Butea Superba monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Cherdshewasart W, Nimsakul N. Clinical trial of Butea superba, an alternative herbal treatment for erectile dysfunction. Asian J Androl 2003;5:243-6.
  2. Cortés-González JR, Arratia-Maqueo JA, Gómez-Guerra LS, Holmberg AR. The use of Butea superba (Roxb.) compared to sildenafil for treating erectile dysfunction. BJU Int 2010;105(2):225-8. doi: 10.1111/j.1464-410X.2009.08748.x.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Butea Superba and Imipramine Together: Common Questions

Is it safe to take Butea Superba with Imipramine?
We do not list a known interaction between Butea Superba and Imipramine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Butea Superba and Imipramine combination checked?
Interactions in our licensed database are recorded against drug classes. Imipramine is filed under 15 classifications, and Butea Superba has documented interactions with 1 drug class — none of Imipramine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Butea Superba interact with any other medications?
Yes. Butea Superba has 7 documented drug interactions in our database — Imipramine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Imipramine interact with any supplements?
Yes. Imipramine has documented interactions with 254 supplements in our database — Butea Superba is not one of them. The Imipramine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Butea Superba monograph Uses, safety profile, and every drug interaction in one place Imipramine drug information The full plain-English guide to this medication Imipramine supplement interactions Every supplement checked against Imipramine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Imipramine and Butea Superba?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.