Drug & supplement interaction

Calabar Bean + Oxymetazoline Hydrochloride

Oxymetazoline Hydrochloride brand names: Afrin, Rhofade, Upneeq.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Calabar Bean and Oxymetazoline Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Calabar Bean and Oxymetazoline Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Oxymetazoline Hydrochloride and Calabar Bean in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Calabar Bean safety at a glance

Calabar Bean overall Avoid The raw bean is poisonous and can cause severe, even fatal, poisoning.
Pregnancy Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Oxymetazoline Hydrochloride and Calabar Bean? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Oxymetazoline Hydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Oxymetazoline Hydrochloride is filed under 3 classifications — alpha-adrenergic agonists, stimulant drugs, topical drugs. Calabar Bean has documented interactions with 1 drug class — the most serious being anticholinergic drugs (minor) — and none of Oxymetazoline Hydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Calabar Bean Does Interact With Other Medications

Calabar Bean has 195 minor known drug interactions in our database — Oxymetazoline Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Minor 195 No known interaction 2,635 (incl. Oxymetazoline Hydrochloride)
Taking anything else?

Check Another of Your Medications Against Calabar Bean

Covers the 2,830 medications we’ve checked against Calabar Bean. Pick one to open its full report.

What to actually watch for

What Calabar Bean Itself Has Been Linked To

This is not an interaction — nothing below involves Oxymetazoline Hydrochloride. It is the side-effect record for Calabar Bean on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Calabar Bean, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Muscle weakness / A slow heartbeat / Confusion Worth acting on Additional detail

    “Orally, physostigmine, a constituent of calabar bean, can cause cholinergic crisis, including paralysis, coma, and death. Other symptoms of cholinergic crisis may include bradycardia, confusion, diarrhea, miosis, muscle weakness, salivation, sweating, and vomiting (15).”

    Calabar Bean · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  • Seizures Worth acting on Additional detail

    Recorded for Calabar Bean in the same Natural Medicines adverse-effect record shown under Muscle weakness / A slow heartbeat / Confusion above.

  • Raised blood pressure Worth acting on Additional detail

    “Orally, calabar bean can cause bradycardia, tachycardia, hypotension, and hypertension (15).”

    Calabar Bean · Natural Medicines adverse-effect record, reported in hypertension.

    1 source cited
    1. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  • Sweating / Diarrhea / Vomiting Additional detail

    Recorded for Calabar Bean in the same Natural Medicines adverse-effect record shown under Muscle weakness / A slow heartbeat / Confusion above.

  • A fast or pounding heartbeat / Low blood pressure Additional detail

    Recorded for Calabar Bean in the same Natural Medicines adverse-effect record shown under Muscle weakness / A slow heartbeat / Confusion above.

Everything above comes from the Natural Medicines adverse-effect record for Calabar Bean — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Oxymetazoline Hydrochloride’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Oxymetazoline Hydrochloride column appears here.

Special populations

Calabar Bean in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Oxymetazoline Hydrochloride

This page covers Calabar Bean only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Oxymetazoline Hydrochloride page lists 48 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Ephedra (major), Peyote (major), Rauvolfia Vomitoria (major), Sida Cordifolia (major) and 1,3-dmaa (moderate).

By severity: 4 major · 39 moderate · 5 minor.

Open the Oxymetazoline Hydrochloride interaction page

How much people look this up

Where Calabar Bean and Oxymetazoline Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Calabar Bean
Steady interest

#983 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Oxymetazoline Hydrochloride
Top half

#1,272 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Calabar Bean reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Calabar Bean and Oxymetazoline Hydrochloride records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Calabar Bean

What is Calabar Bean?

Calabar Bean
  • Source of physostigmine (a prescription drug ingredient)
  • Historically used in 'trial by ordeal' rituals
  • Traditional pain relief and anti-inflammatory uses
  • Historically used for eye conditions (glaucoma)
  • Historically used as a poison

Calabar bean is a highly poisonous West African seed that contains physostigmine, a powerful cholinesterase inhibitor. It is not a safe dietary supplement, and eating the bean can cause serious poisoning or death. Only the purified, regulated drug physostigmine has a legitimate medical use, and that must be prescribed and monitored by a doctor.

Physostigma venenosum · Fabaceae · Seeds (beans) · Not available as a safe consumer supplement; historically the seed and its extracts were used, and the alkaloid physostigmine is used in prescription medicines

An interaction check asks whether these two react with each other — it does not ask whether Calabar Bean is a good idea for someone in your situation. Here is what our Calabar Bean record says about it on its own.

Calabar Bean: dosing

There is no safe or established dose of Calabar bean for self-care, and it should not be taken as a supplement. The bean is poisonous, and the amount of physostigmine it contains can vary, making any home use extremely risky.The only proper medical use of this plant's active compound is the regulated prescription drug physostigmine, which a doctor doses precisely and monitors closely. Never attempt to use the bean yourself.

From our Calabar Bean monograph — the full record covers uses, side effects and every documented interaction.

Read the full Calabar Bean monograph & all interactions
Medication

About Oxymetazoline Topical

What Is Oxymetazoline Topical Used For?

Brand names: Afrin, Rhofade, Upneeq

The cream form (Rhofade, oxymetazoline hydrochloride cream 1%) is used on the skin to treat persistent facial redness (erythema) from rosacea in adults.

Other products in this group, such as Afrin spray and the nasal solutions listed, carry over-the-counter warnings. These warnings refer to nasal congestion, but the supplied evidence does not list a full indication for them.

Most-Reported Side Effects for Oxymetazoline Hydrochloride

From FAERS, the FDA’s public side-effect reporting system (6,780 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug dependence 1,129 reports
Headache 361 reports
Anosmia 286 reports
Vision blurred 286 reports
Dyspnea 268 reports
See full Oxymetazoline Topical drug information
Keep checking

Other Drugs & Calabar Bean

Browse every other medication we’ve checked against Calabar Bean — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
195Minor
2,634No known interaction
195 Minor 2,634 No interaction
Minor

195 interactions

Showing 60 of 195 minor interactions — see all 195 on the Calabar Bean page.

No interaction 2,634 drugs checked — show the list

We also checked Calabar Bean against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,634 medications checked with no known interaction — see the full Calabar Bean list.

See the full Calabar Bean interactions page
See every supplement checked against Oxymetazoline Hydrochloride, ranked by severity
Evidence & sources

Calabar Bean References

The 2 references that drive our Calabar Bean monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Calabar Bean and Oxymetazoline Hydrochloride Together: Common Questions

Is it safe to take Calabar Bean with Oxymetazoline Hydrochloride?
We do not list a known interaction between Calabar Bean and Oxymetazoline Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Calabar Bean and Oxymetazoline Hydrochloride combination checked?
Interactions in our licensed database are recorded against drug classes. Oxymetazoline Hydrochloride is filed under 3 classifications, and Calabar Bean has documented interactions with 1 drug class — none of Oxymetazoline Hydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Calabar Bean interact with any other medications?
Yes. Calabar Bean has 195 documented drug interactions in our database — Oxymetazoline Hydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Oxymetazoline Hydrochloride interact with any supplements?
Yes. Oxymetazoline Hydrochloride has documented interactions with 48 supplements in our database — Calabar Bean is not one of them. The Oxymetazoline Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Calabar Bean monograph Uses, safety profile, and every drug interaction in one place Oxymetazoline Topical drug information The full plain-English guide to this medication Oxymetazoline Hydrochloride supplement interactions Every supplement checked against Oxymetazoline Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Oxymetazoline Hydrochloride and Calabar Bean?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.