Drug & supplement interaction

Canadian Fleabane + Voxelotor

Voxelotor brand name: Oxbryta.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Canadian Fleabane and Voxelotor in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Canadian Fleabane and Voxelotor

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Voxelotor and Canadian Fleabane in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Canadian Fleabane safety at a glance

Canadian Fleabane overall Use caution Used traditionally, but human safety data are limited so use cautiously.
Pregnancy Avoid Not enough safety information, so avoid use during pregnancy.
Breastfeeding Avoid Not enough safety information, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Voxelotor and Canadian Fleabane? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Voxelotor

Interactions in our licensed database are recorded against drug classes, not just single drug names. Voxelotor is filed under 3 classifications — cytochrome p450 3a4 (cyp3a4) inhibitors, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Canadian Fleabane has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Voxelotor’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Canadian Fleabane Does Interact With Other Medications

Canadian Fleabane has 122 moderate known drug interactions in our database — Voxelotor isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Voxelotor)
Taking anything else?

Check Another of Your Medications Against Canadian Fleabane

Covers the 2,830 medications we’ve checked against Canadian Fleabane. Pick one to open its full report.

What to actually watch for

What Voxelotor’s Own FDA Label Lists

This is not an interaction — none of it involves Canadian Fleabane. These are the most notable effects listed in the ADVERSE REACTIONS section of Voxelotor’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Hives Worth acting on
  • An allergic reaction Worth acting on
  • Diarrhea mentioned in 14.3% of FDA reports for Voxelotor
  • Stomach pain mentioned in 5.3% of FDA reports for Voxelotor
  • Fever
  • Headache mentioned in 7.6% of FDA reports for Voxelotor
  • Nausea mentioned in 9.0% of FDA reports for Voxelotor
  • A skin rash

From the ADVERSE REACTIONS section of the FDA label for Voxelotor. Read the label on DailyMed › Where a percentage is shown, it is the share of 22,291 voluntary FDA FAERS reports for Voxelotor that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Canadian Fleabane’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Canadian Fleabane side to compare — that is a limit of the record, not a statement that Canadian Fleabane has no side effects.

Everything else you take

See Every Supplement That Interacts With Voxelotor

This page covers Canadian Fleabane only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Voxelotor page lists 143 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 100 moderate · 40 minor.

From our pharmacist’s overview on the Voxelotor page

“Anyone taking voxelotor (Oxbryta) for sickle cell disease should treat this list with real care, because the pattern behind it is unusually consistent. Almost every entry works through CYP3A4, the same liver enzyme that clears voxelotor, so these ingredients can push the drug's blood level higher or pull it lower, either adding side ef…”

Reviewed by 2 · Jul 18, 2026

Open the Voxelotor interaction page

How much people look this up

Where Canadian Fleabane and Voxelotor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Canadian Fleabane
Top half

#392 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Voxelotor
Steady interest

#2,247 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Canadian Fleabane reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Canadian Fleabane and Voxelotor records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Canadian Fleabane

What is Canadian Fleabane?

  • Diarrhea
  • Minor bleeding
  • Urinary complaints
  • Digestive upset
  • Sore throat and inflammation

Canadian Fleabane is a common North American weed used in traditional medicine for diarrhea, minor bleeding, and urinary issues, but high-quality human studies are lacking. Because its safety has not been well studied, it is best to talk with your pharmacist or doctor before using it, and to avoid it during pregnancy and breastfeeding.

Erigeron canadensis · Asteraceae · Aerial parts (leaves, stems, flowers) and the essential oil · Tea, tincture, dried herb, liquid extract, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Canadian Fleabane is a good idea for someone in your situation. Here is what our Canadian Fleabane record says about it on its own.

Canadian Fleabane: dosing

There is no established, science-based standard dose for Canadian Fleabane. Traditional preparations such as teas and tinctures vary widely in strength, and product labels differ from brand to brand.If you choose to use a commercial product, follow the directions on the label and do not exceed them. The essential oil is very concentrated and is not meant to be taken by mouth without professional guidance.

From our Canadian Fleabane monograph — the full record covers uses, side effects and every documented interaction.

Read the full Canadian Fleabane monograph & all interactions
Medication

About Voxelotor

What Is Voxelotor Used For?

Brand name: Oxbryta

Oxbryta (voxelotor) is approved to treat sickle cell disease (SCD) in adults and in children as young as 4 years old. It works by targeting the underlying problem in sickle cell disease — the abnormal hemoglobin that causes red blood cells to take on a rigid, sickle shape.

This approval was granted under the FDA's accelerated approval pathway, based on the drug's ability to raise hemoglobin levels. Continued approval may depend on results from confirmatory clinical trials showing broader clinical benefit.

Most-Reported Side Effects for Voxelotor

From FAERS, the FDA’s public side-effect reporting system (22,300 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Sickle cell anaemia with crisis 11,218 reports
Diarrhea 3,187 reports
Nausea 2,016 reports
Headache 1,691 reports
Abdominal pain upper 1,171 reports
See full Voxelotor drug information
Keep checking

Other Drugs & Canadian Fleabane

Browse every other medication we’ve checked against Canadian Fleabane — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Canadian Fleabane page.

No interaction 2,707 drugs checked — show the list

We also checked Canadian Fleabane against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Canadian Fleabane list.

See the full Canadian Fleabane interactions page
See every supplement checked against Voxelotor, ranked by severity
Evidence & sources

Canadian Fleabane References

The 2 references that drive our Canadian Fleabane monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Saluk-Juszczak J, Olas B, Pawlaczyk I, Gancarz R, Wachowicz B. Effects of the extract from Conyza canadensis on human blood platelet aggregation. Gen Physiol Biophys 2007;26(2):150-2.
  2. Olas B, Saluk-Juszczak J, Pawlaczyk I, et al. Antioxidant and antiaggregatory effects of an extract from Conyza canadensis on blood platelets in vitro. Platelets 2006;17(6):354-60.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Canadian Fleabane and Voxelotor Together: Common Questions

Is it safe to take Canadian Fleabane with Voxelotor?
We do not list a known interaction between Canadian Fleabane and Voxelotor. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Canadian Fleabane and Voxelotor combination checked?
Interactions in our licensed database are recorded against drug classes. Voxelotor is filed under 3 classifications, and Canadian Fleabane has documented interactions with 1 drug class — none of Voxelotor's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Canadian Fleabane interact with any other medications?
Yes. Canadian Fleabane has 122 documented drug interactions in our database — Voxelotor is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Voxelotor interact with any supplements?
Yes. Voxelotor has documented interactions with 143 supplements in our database — Canadian Fleabane is not one of them. The Voxelotor interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Canadian Fleabane monograph Uses, safety profile, and every drug interaction in one place Voxelotor drug information The full plain-English guide to this medication Voxelotor supplement interactions Every supplement checked against Voxelotor, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Voxelotor and Canadian Fleabane?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.