Cassava - Repatha (Evolocumab) Interaction
Herbal: Cassava
Also Known As: Manihot esculenta, Brazilian Arrowroot, Cassave, Kassava, Kassave, Mandioca, Manioc, Manioc Tapioca, Manioca, Maniok, Maniokki, Tapioca, Tapioca Plant, Yuca
Drug: Evolocumab
Brand names:
Repatha
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
There were no interactions found between Evolocumab and Cassava. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Cassava Overview
Cassava, also known as yuca, is a starchy root vegetable and a dietary mainstay in numerous tropical and developing nations. Despite its nutritional significance, cassava is not without concern, as it contains potentially harmful cyanogenic glycosides. Ongoing research is directed towards the development of genetically modified variants with reduced toxicity, aiming to mitigate health-related concers associated with its consumption.
In addition to its role as a dietary staple, cassava supplements are sometimes marketed as a fertility aid, specifically highlighting an increased probability of conceiving twins. This claim is grounded in the notion that select cassava supplements can induce hyper-ovulation without the adverse effects commonly associated with prescription fertility medications. It is pertinent to note, however, that this assertion currently lacks any substantiation in studies.
Beyond its purported use for fertility, available evidence suggests a potential reduction in the risk of developing type 2 diabetes with an increased intake of cassava flour in the diet.
Evolocumab Overview
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Evolocumab injection is used to reduce the risk of a stroke or heart attack or the need for coronary artery bypass (CABG) surgery in people with cardiovascular disease. Evolocumab injection is also used along with diet alone or in combination with other cholesterol-lowering medications such as HMG-CoA reductase inhibitors (statins) or ezetimbe (Zetia) to decrease the amount of low-density lipoprotein (LDL) cholesterol ('bad cholesterol') in the blood, including people who have familial heterozygous hypercholesterolemia (HeFH; an inherited condition in which cholesterol cannot be removed from the body normally). It is also used along with diet changes and other treatments to reduce the amount low-density lipoprotein (LDL) cholesterol ('bad cholesterol')in the blood in people that have homozygous familial hypercholesterolemia (HoFH; an inherited condition in which cholesterol cannot be removed from the body normally). Evolocumab injection is in a class of medications called proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor monoclonal antibody. It works by blocking the production of LDL cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
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Accumulation of cholesterol along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body.
Cassava - More Interactions
Cassava interacts with 16 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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