Drug & supplement interaction

Cassia Auriculata + Chlorpropamide

Chlorpropamide brand names: Diabinese, Chlorpropam.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Cassia Auriculata has a moderate interaction with Chlorpropamide. Theoretically, Cassia auriculata may reduce blood glucose levels and might have additive effects on glucose levels when used with antidiabetes drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Cassia Auriculata and Chlorpropamide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Chlorpropamide

Chlorpropamide falls under ANTIDIABETES DRUGS — the group Cassia Auriculata interacts with.

Theoretically, Cassia auriculata may reduce blood glucose levels and might have additive effects on glucose levels when used with antidiabetes drugs. Monitor blood glucose levels closely. Medication dose adjustments may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: chlorpropamide already lowers your blood sugar by pushing your pancreas to release more insulin. Cassia auriculata has been studied (mostly in lab and animal research) for its own blood-sugar-lowering effects. So when you stack the two together, the worry is that their effects could add up and drop your sugar lower than intended.

If that happens, you might feel the classic signs of low blood sugar: shakiness, sweating, dizziness, confusion, or a racing heart. Chlorpropamide is a longer-acting sulfonylurea, so a low can linger longer than with some others. I want to be honest though, this interaction is mostly theoretical for now. Please don't start, stop, or change anything on your own. Check with your pharmacist or doctor first, and keep an eye on your home glucose readings if you do combine them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Latha M, Pari L. Antihyperglycaemic effect of Cassia auriculata in experimental diabetes and its effects on key metabolic enzymes involved in carbohydrate metabolism. Clin Exp Pharmacol Physiol 2003;30:38-43.
  2. Pari L, Ramakrishnan R, Venkateswaran S. Antihyperglycaemic effect of Diamed, a herbal formulation, in experimental diabetes in rats. J Pharm Pharmacol 2001;53:1139-43. PubMed
  3. Nambirajan G, Karunanidhi K, Ganesan A, et al. Evaluation of antidiabetic activity of bud and flower of Avaram Senna (Cassia auriculata L.) In high fat diet and streptozotocin induced diabetic rats. Biomed Pharmacother. 2018;108:1495-1506. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cassia Auriculata Also Interacts With Other Medications

Cassia Auriculata has 86 moderate known drug interactions in our database — the Chlorpropamide one above is one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Chlorpropamide)
Taking anything else?

Check Another of Your Medications Against Cassia Auriculata

Covers the 2,830 medications we’ve checked against Cassia Auriculata. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Chlorpropamide

This page covers Cassia Auriculata only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chlorpropamide page lists 328 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and 1,3-dmaa (moderate).

By severity: 4 major · 282 moderate · 42 minor.

From our pharmacist’s overview on the Chlorpropamide page

“Someone taking chlorpropamide (Diabinese) for type 2 diabetes is often the same person browsing blood sugar supplements, and that overlap is the problem, so approach this list with genuine care. Most of the 328 ingredients on file, 282 rated moderate, lower glucose on their own; stacked on a pill built to do the same, they can drive bl…”

Reviewed by 2 · Jul 18, 2026

Open the Chlorpropamide interaction page

How much people look this up

Where Cassia Auriculata and Chlorpropamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cassia Auriculata
Steady interest

#1,390 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Chlorpropamide
Top half

#1,240 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cassia Auriculata

What is Cassia Auriculata?

  • Blood sugar support
  • Skin health
  • Urinary complaints
  • Digestive upset
  • General tonic and antioxidant

Cassia auriculata (often called Tanner's cassia or Avaram) is a flowering shrub used in traditional Indian medicine, especially for blood sugar and skin concerns. Most evidence comes from laboratory and animal studies, so its benefits in people are not well proven. Talk to your pharmacist or doctor before using it, particularly if you take diabetes medicine or are pregnant.

Read the full Cassia Auriculata monograph & all interactions
Keep checking

Other Drugs & Cassia Auriculata

Browse every other medication we’ve checked against Cassia Auriculata — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Cassia Auriculata page.

No interaction 2,743 drugs checked — show the list

We also checked Cassia Auriculata against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Cassia Auriculata list.

See the full Cassia Auriculata interactions page
See every supplement checked against Chlorpropamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cassia Auriculata monograph › Uses, safety, and every drug interaction in one place Chlorpropamide supplement interactions › Every supplement checked against Chlorpropamide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cassia Auriculata and Chlorpropamide Together: Common Questions

Can you take Cassia Auriculata with Chlorpropamide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Cassia Auriculata and Chlorpropamide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Chlorpropamide and Cassia Auriculata?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.