Drug & supplement interaction

Cassia Auriculata + Linagliptin

Linagliptin brand name: Tradjenta.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Cassia Auriculata has a moderate interaction with Linagliptin. Theoretically, Cassia auriculata may reduce blood glucose levels and might have additive effects on glucose levels when used with antidiabetes drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Cassia Auriculata and Linagliptin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Linagliptin

Linagliptin falls under ANTIDIABETES DRUGS — the group Cassia Auriculata interacts with.

Theoretically, Cassia auriculata may reduce blood glucose levels and might have additive effects on glucose levels when used with antidiabetes drugs. Monitor blood glucose levels closely. Medication dose adjustments may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: both Linagliptin (Tradjenta) and Cassia auriculata can push your blood sugar in the same direction, which is downward. Linagliptin works by helping your body release more of its own blood-sugar-lowering signals after meals. This herb, in lab and animal studies, also seems to nudge glucose lower. Stack them together and the effects may add up, so your sugar could drop more than expected.

I'll be honest with you though, this concern comes mostly from test-tube and animal research, not solid human studies, so it's more theoretical than proven. Still, watch for low blood sugar signs like shakiness, sweating, dizziness, or feeling foggy. Keep an eye on your home glucose readings, and chat with your pharmacist or doctor before adding it.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Latha M, Pari L. Antihyperglycaemic effect of Cassia auriculata in experimental diabetes and its effects on key metabolic enzymes involved in carbohydrate metabolism. Clin Exp Pharmacol Physiol 2003;30:38-43.
  2. Pari L, Ramakrishnan R, Venkateswaran S. Antihyperglycaemic effect of Diamed, a herbal formulation, in experimental diabetes in rats. J Pharm Pharmacol 2001;53:1139-43. PubMed
  3. Nambirajan G, Karunanidhi K, Ganesan A, et al. Evaluation of antidiabetic activity of bud and flower of Avaram Senna (Cassia auriculata L.) In high fat diet and streptozotocin induced diabetic rats. Biomed Pharmacother. 2018;108:1495-1506. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cassia Auriculata Also Interacts With Other Medications

Cassia Auriculata has 86 moderate known drug interactions in our database — the Linagliptin one above is one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Linagliptin)
Taking anything else?

Check Another of Your Medications Against Cassia Auriculata

Covers the 2,830 medications we’ve checked against Cassia Auriculata. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Linagliptin

This page covers Cassia Auriculata only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Linagliptin page lists 284 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), St. John's Wort (major), Acai (moderate) and Adrafinil (moderate).

By severity: 3 major · 240 moderate · 41 minor.

From our pharmacist’s overview on the Linagliptin page

“Linagliptin (Tradjenta) helps people with type 2 diabetes bring blood sugar down, so most of the 284 supplements and herbs on this page interact for one basic reason: they lower glucose too, and stacking them can drop you into hypoglycemia. I'd read this list with genuine care rather than a shrug.”

Reviewed by 2 · Jul 18, 2026

Open the Linagliptin interaction page

How much people look this up

Where Cassia Auriculata and Linagliptin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cassia Auriculata
Steady interest

#1,396 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Linagliptin
Top half

#1,096 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cassia Auriculata

What is Cassia Auriculata?

  • Blood sugar support
  • Skin health
  • Urinary complaints
  • Digestive upset
  • General tonic and antioxidant

Cassia auriculata (often called Tanner's cassia or Avaram) is a flowering shrub used in traditional Indian medicine, especially for blood sugar and skin concerns. Most evidence comes from laboratory and animal studies, so its benefits in people are not well proven. Talk to your pharmacist or doctor before using it, particularly if you take diabetes medicine or are pregnant.

Read the full Cassia Auriculata monograph & all interactions
Medication

About Linagliptin

What Is Linagliptin Used For?

Brand name: Tradjenta

Tradjenta (linagliptin) is used to help control blood sugar in adults with type 2 diabetes. It is meant to be used together with healthy eating and regular exercise, not as a replacement for them.

Linagliptin is not for type 1 diabetes, and it has not been studied in people with a history of pancreatitis.

See full Linagliptin drug information
Keep checking

Other Drugs & Cassia Auriculata

Browse every other medication we’ve checked against Cassia Auriculata — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Cassia Auriculata page.

No interaction 2,743 drugs checked — show the list

We also checked Cassia Auriculata against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Cassia Auriculata list.

See the full Cassia Auriculata interactions page
See every supplement checked against Linagliptin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cassia Auriculata monograph › Uses, safety, and every drug interaction in one place Linagliptin supplement interactions › Every supplement checked against Linagliptin, ranked by severity Linagliptin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cassia Auriculata and Linagliptin Together: Common Questions

Can you take Cassia Auriculata with Linagliptin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Cassia Auriculata and Linagliptin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Linagliptin and Cassia Auriculata?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.