Drug & supplement interaction

Cassia Auriculata + Olutasidenib

Olutasidenib brand name: Rezlidihia.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Cassia Auriculata and Olutasidenib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Olutasidenib states a food rule worth keeping to.

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Interaction report

Cassia Auriculata and Olutasidenib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Olutasidenib and Cassia Auriculata in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cassia Auriculata safety at a glance

Cassia Auriculata overall Use caution Generally used in traditional diets, but human safety data is limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Olutasidenib and Cassia Auriculata? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Olutasidenib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Olutasidenib is filed under 4 classifications — including cytochrome p450 3a4 (cyp3a4) inducers, hepatotoxic drugs, cytochrome p450 3a4 (cyp3a4) substrates. Cassia Auriculata has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and carbamazepine (tegretol) (moderate) — and none of Olutasidenib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cassia Auriculata Does Interact With Other Medications

Cassia Auriculata has 87 moderate known drug interactions in our database — Olutasidenib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 87 No known interaction 2,743 (incl. Olutasidenib)
Taking anything else?

Check Another of Your Medications Against Cassia Auriculata

Covers the 2,830 medications we’ve checked against Cassia Auriculata. Pick one to open its full report.

What to actually watch for

What Olutasidenib’s Own FDA Label Lists

This is not an interaction — none of it involves Cassia Auriculata. These are the most notable effects listed in the ADVERSE REACTIONS section of Olutasidenib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • Yellowing of the skin or eyes Worth acting on
  • Kidney problems Worth acting on
  • Raised blood pressure Worth acting on
  • Shortness of breath Worth acting on
  • Liver problems Worth acting on
  • Weight gain
  • Pain in an arm or leg
  • Mouth irritation or sores
  • Sore throat
  • Back pain

Showing the 10 most notable of 23 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Olutasidenib. Read the label on DailyMed › Cassia Auriculata’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Cassia Auriculata side to compare — that is a limit of the record, not a statement that Cassia Auriculata has no side effects.

How to take them

Some Olutasidenib Products Have a Food Rule — Cassia Auriculata Should Not Break It

At least one FDA label for a product containing Olutasidenib says to take it on an empty stomach. Most supplements — Cassia Auriculata included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Olutasidenib on its own and move Cassia Auriculata to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Olutasidenib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.2 ) Take on an empty stomach at least 1 hour before or 2 hours after a meal.

From the Dosage and Administration section of the FDA label we read for Olutasidenib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Olutasidenib

This page covers Cassia Auriculata only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Olutasidenib page lists 180 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 137 moderate · 37 minor.

From our pharmacist’s overview on the Olutasidenib page

“Olutasidenib (Rezlidihia) treats a form of acute myeloid leukemia, where keeping drug levels steady genuinely matters, so I'd approach this list with real care. Six of the 180 ingredients rate major, and they split into two problems: products that change how much olutasidenib reaches your blood, and products that strain the liver.”

Reviewed by 2 · Jul 18, 2026

Open the Olutasidenib interaction page

How much people look this up

Where Cassia Auriculata and Olutasidenib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cassia Auriculata
Steady interest

#1,138 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Olutasidenib
Steady interest

#2,400 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cassia Auriculata reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cassia Auriculata and Olutasidenib records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cassia Auriculata

What is Cassia Auriculata?

  • Blood sugar support
  • Skin health
  • Urinary complaints
  • Digestive upset
  • General tonic and antioxidant

Cassia auriculata (often called Tanner's cassia or Avaram) is a flowering shrub used in traditional Indian medicine, especially for blood sugar and skin concerns. Most evidence comes from laboratory and animal studies, so its benefits in people are not well proven. Talk to your pharmacist or doctor before using it, particularly if you take diabetes medicine or are pregnant.

Senna auriculata · Fabaceae · Flowers, leaves, bark, seeds, and roots · Tea, powder (churna), capsules, and traditional decoctions

An interaction check asks whether these two react with each other — it does not ask whether Cassia Auriculata is a good idea for someone in your situation. Here is what our Cassia Auriculata record says about it on its own.

Cassia Auriculata: dosing

There is no well-established, standardized dose for Cassia auriculata. Traditional use has varied widely depending on the part of the plant and the preparation, such as a tea made from dried flowers or a powder.Because supplements differ in strength, the best advice is to follow the directions on the product label and not exceed the recommended amount.

From our Cassia Auriculata monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cassia Auriculata monograph & all interactions
Medication

About Olutasidenib

What Is Olutasidenib Used For?

Brand name: Rezlidihia

Rezlidhia (olutasidenib) is used to treat adults with acute myeloid leukemia (AML) — a fast-moving blood cancer — when the disease has come back or stopped responding to previous treatment. It is only for patients whose leukemia cells carry a susceptible IDH1 mutation, which must be confirmed by an FDA-approved test before starting treatment.

See full Olutasidenib drug information
Keep checking

Other Drugs & Cassia Auriculata

Browse every other medication we’ve checked against Cassia Auriculata — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
87Moderate
0Minor
2,742No known interaction
87 Moderate 2,742 No interaction
Moderate

87 interactions

Showing 60 of 87 moderate interactions — see all 87 on the Cassia Auriculata page.

No interaction 2,742 drugs checked — show the list

We also checked Cassia Auriculata against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,742 medications checked with no known interaction — see the full Cassia Auriculata list.

See the full Cassia Auriculata interactions page
See every supplement checked against Olutasidenib, ranked by severity
Evidence & sources

Cassia Auriculata References

The 4 references that drive our Cassia Auriculata monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Latha M, Pari L. Antihyperglycaemic effect of Cassia auriculata in experimental diabetes and its effects on key metabolic enzymes involved in carbohydrate metabolism. Clin Exp Pharmacol Physiol 2003;30:38-43.
  2. Pari L, Ramakrishnan R, Venkateswaran S. Antihyperglycaemic effect of Diamed, a herbal formulation, in experimental diabetes in rats. J Pharm Pharmacol 2001;53:1139-43. PubMed
  3. Thabrew I, Munasinghe J, Chackrewarthi S, Senarath S. The effects of Cassia auriculata and Cardiospermum halicacabum teas on the steady state blood level and toxicity of carbamazepine. J Ethnopharmacol 2004;90:145-50. PubMed
  4. Nambirajan G, Karunanidhi K, Ganesan A, et al. Evaluation of antidiabetic activity of bud and flower of Avaram Senna (Cassia auriculata L.) In high fat diet and streptozotocin induced diabetic rats. Biomed Pharmacother. 2018;108:1495-1506. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cassia Auriculata and Olutasidenib Together: Common Questions

Is it safe to take Cassia Auriculata with Olutasidenib?
We do not list a known interaction between Cassia Auriculata and Olutasidenib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Cassia Auriculata and Olutasidenib at the same time of day?
At least one FDA label for a product containing Olutasidenib says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Olutasidenib on its own and move Cassia Auriculata to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Cassia Auriculata and Olutasidenib combination checked?
Interactions in our licensed database are recorded against drug classes. Olutasidenib is filed under 4 classifications, and Cassia Auriculata has documented interactions with 2 drug classes — none of Olutasidenib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Cassia Auriculata interact with any other medications?
Yes. Cassia Auriculata has 87 documented drug interactions in our database — Olutasidenib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Olutasidenib interact with any supplements?
Yes. Olutasidenib has documented interactions with 180 supplements in our database — Cassia Auriculata is not one of them. The Olutasidenib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cassia Auriculata monograph Uses, safety profile, and every drug interaction in one place Olutasidenib drug information The full plain-English guide to this medication Olutasidenib supplement interactions Every supplement checked against Olutasidenib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Olutasidenib and Cassia Auriculata?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.