Drug & supplement interaction

Cassia Cinnamon + Mannitol

Mannitol brand names: Osmitrol, Bronchitol.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Cassia Cinnamon and Mannitol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Cassia Cinnamon and Mannitol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mannitol and Cassia Cinnamon in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cassia Cinnamon safety at a glance

Cassia Cinnamon overall Use caution Generally safe in food amounts, but supplement doses high in coumarin may harm the liver over time.
Pregnancy Likely Safe When consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of cassia cinnamon when used in medicina... Read the full pregnancy detail
Breastfeeding Likely Safe When consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of cassia cinnamon when used in medicina... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mannitol and Cassia Cinnamon? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Mannitol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Mannitol is filed under 3 classifications — diuretic drugs, antihypertensive drugs, oral drugs. Cassia Cinnamon has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and hepatotoxic drugs (moderate) — and none of Mannitol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cassia Cinnamon Does Interact With Other Medications

Cassia Cinnamon has 442 moderate known drug interactions in our database — Mannitol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 442 No known interaction 2,388 (incl. Mannitol)
Taking anything else?

Check Another of Your Medications Against Cassia Cinnamon

Covers the 2,830 medications we’ve checked against Cassia Cinnamon. Pick one to open its full report.

What to actually watch for

What Cassia Cinnamon Itself Has Been Linked To

This is not an interaction — nothing below involves Mannitol. It is the side-effect record for Cassia Cinnamon on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Cassia Cinnamon, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on Additional detail

    “In one clinical trial, a hypoglycemic seizure was reported in one patient taking cassia cinnamon 1 gram daily for 3 months. The event occurred one day after enrolling in the study. It is unclear if cassia cinnamon caused this event.”

    Cassia Cinnamon · Natural Medicines adverse-effect record, reported in epilepsy.

    1 source cited
    1. 89648. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  • Liver problems Worth acting on Additional detail

    “There is some concern about the safety of ingesting large amounts of cassia cinnamon for extended durations due to its coumarin content. Coumarin can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin is discontinued.”

    Cassia Cinnamon · Natural Medicines adverse-effect record, reported in cirrhosis.

    6 sources cited
    1. 15299. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
    2. 15302. Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
    3. 21918. Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
    4. 96280. Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
    5. 108259. Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
    6. 97249. Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
  • An allergic reaction Worth acting on Additional detail

    “In one clinical trial, a rash was reported in one patient taking cassia cinnamon 1 gram daily for 90 days.

    In one case, a 58-year-old female with a documented allergy to topically applied cinnamic alcohol presented with eyelid dermatitis, which was found to be a manifestation of systemic contact dermatitis to cinnamon in the diet.”

    Cassia Cinnamon · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    6 sources cited
    1. 17011. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
    2. 95599. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
    3. 113516. Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed
    4. 113515. Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
    5. 11915. De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
    6. 11920. Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
  • Mouth irritation or sores / A skin rash Additional detail

    Recorded for Cassia Cinnamon in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

Everything above comes from the Natural Medicines adverse-effect record for Cassia Cinnamon — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Mannitol’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Mannitol column appears here.

Special populations

Cassia Cinnamon in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of cassia cinnamon when used in medicinal amounts during pregnancy and breast-feeding. Stay on the safe side and stick to food amounts.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Mannitol

This page covers Cassia Cinnamon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mannitol page lists 200 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Lithium (major) and Oleander (major).

By severity: 7 major · 169 moderate · 24 minor.

From our pharmacist’s overview on the Mannitol page

“American hellebore tops my worry list for anyone on mannitol (Osmitrol, Bronchitol), an osmotic diuretic used to draw fluid off the brain or, when inhaled, to clear mucus in cystic fibrosis. The plant's alkaloids drop blood pressure and slow the heart, a dangerous match for a drug that already shifts fluid and pressure quickly.”

Reviewed by 2 · Jul 18, 2026

Open the Mannitol interaction page

One more smart check

Taking Cassia Cinnamon as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3,249 real supplement products containing Cassia Cinnamon, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cassia Cinnamon. Even though Cassia Cinnamon itself has no known interaction with Mannitol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cassia Cinnamon and Mannitol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cassia Cinnamon
Top 10%

#77 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mannitol
Top 25%

#403 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cassia Cinnamon reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Cassia Cinnamon and Mannitol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cassia Cinnamon

What is Cassia Cinnamon?

Cassia Cinnamon
  • Blood sugar support
  • Digestive upset
  • Antioxidant support
  • Flavoring and culinary use
  • Antimicrobial

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed and far from proven, and because cassia is naturally high in coumarin, taking large amounts regularly may stress the liver. Use food amounts freely, but talk with a pharmacist or doctor before using high-dose supplements.

Cinnamomum cassia · Lauraceae · Inner bark (and young twigs) · Ground spice, sticks (quills), capsules, tea, extracts, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Cassia Cinnamon is a good idea for someone in your situation. Here is what our Cassia Cinnamon record says about it on its own.

Cassia Cinnamon: dosing

There is no official or well-established medicinal dose for cassia cinnamon. Studies have used a range of amounts, but the results are not consistent enough to recommend a specific dose.If you choose to use a supplement, follow the directions on the product label and do not exceed them. Because of the coumarin content, it is wise to avoid taking large amounts of cassia cinnamon every day for long periods.

From our Cassia Cinnamon monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cassia Cinnamon monograph & all interactions
Medication

About Mannitol

Most-Reported Side Effects for Mannitol

From FAERS, the FDA’s public side-effect reporting system (4,912 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Renal failure 592 reports
Anxiety 505 reports
Injury 495 reports
Unevaluable event 470 reports
Stress 463 reports
Keep checking

Other Drugs & Cassia Cinnamon

Browse every other medication we’ve checked against Cassia Cinnamon — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
442Moderate
0Minor
2,387No known interaction
442 Moderate 2,387 No interaction
Moderate

442 interactions

Showing 60 of 442 moderate interactions — see all 442 on the Cassia Cinnamon page.

No interaction 2,387 drugs checked — show the list

We also checked Cassia Cinnamon against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,387 medications checked with no known interaction — see the full Cassia Cinnamon list.

See the full Cassia Cinnamon interactions page
See every supplement checked against Mannitol, ranked by severity
Evidence & sources

Cassia Cinnamon References

The 20 references that drive our Cassia Cinnamon monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
  3. De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
  4. Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
  6. Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
  7. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
  8. Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
  9. Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
  10. Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
  11. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  12. Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
  13. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
  14. Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
  15. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cassia Cinnamon and Mannitol Together: Common Questions

Is it safe to take Cassia Cinnamon with Mannitol?
We do not list a known interaction between Cassia Cinnamon and Mannitol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Cassia Cinnamon and Mannitol combination checked?
Interactions in our licensed database are recorded against drug classes. Mannitol is filed under 3 classifications, and Cassia Cinnamon has documented interactions with 2 drug classes — none of Mannitol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Cassia Cinnamon interact with any other medications?
Yes. Cassia Cinnamon has 442 documented drug interactions in our database — Mannitol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Mannitol interact with any supplements?
Yes. Mannitol has documented interactions with 200 supplements in our database — Cassia Cinnamon is not one of them. The Mannitol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cassia Cinnamon monograph Uses, safety profile, and every drug interaction in one place Mannitol supplement interactions Every supplement checked against Mannitol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 20 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mannitol and Cassia Cinnamon?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.