Drug & supplement interaction

Cat's Claw + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide

Aluminum Hydroxide, Aspirin, Magnesium Hydroxide brand name: Ascriptin.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Cat's Claw has a moderate interaction with Aluminum Hydroxide, Aspirin, Magnesium Hydroxide. Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Cat's Claw and Aluminum Hydroxide, Aspirin, Magnesium Hydroxide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Aluminum Hydroxide, Aspirin, Magnesium Hydroxide

Aluminum Hydroxide, Aspirin, Magnesium Hydroxide falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Cat's Claw interacts with.

Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Cat's claw contains rhynchophylline and isorhynchophylline. Animal research suggests that these alkaloids can inhibit platelet aggregation. This interaction has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

The product you're asking about (Ascriptin) contains aspirin along with two antacids. Aspirin is an antiplatelet, meaning it makes your platelets less sticky so blood clots more slowly. Here's the concern: cat's claw contains compounds that, in lab and animal studies, also seem to slow platelets down. Stack the two together and you could, in theory, tip toward easier bruising, nosebleeds, bleeding gums, or a cut that takes longer to stop.

I want to be honest about the evidence though. This effect has only shown up in test tubes and animals, never confirmed in people, so it's a theoretical caution rather than a proven problem. Still, since aspirin already thins the blood, it's worth a quick chat with your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Chen, C. X., Jin, R. M., Li, Y. K., Zhong, J., Yue, L., Chen, S. C., and Zhou, J. Y. Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis. Zhongguo Yao Li Xue.Bao. 1992;13(2):126-130.
  2. Hemingway, S. R. and Phillipson, J. D. Proceedings: Alkaloids from S. American species of Uncaria (Rubiaceae). J.Pharm.Pharmacol. 1974;26 Suppl:113P.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cat's Claw Also Interacts With Other Medications

Cat's Claw has 963 moderate known drug interactions in our database — the Aluminum Hydroxide, Aspirin, Magnesium Hydroxide one above is one of them. If you take anything else, check it against the full list below.

Moderate 963 No known interaction 1,867 (incl. Aluminum Hydroxide, Aspirin, Magnesium Hydroxide)
Taking anything else?

Check Another of Your Medications Against Cat's Claw

Covers the 2,830 medications we’ve checked against Cat's Claw. Pick one to open its full report.

From our Q&A

Questions About Cat's Claw or Aluminum Hydroxide, Aspirin, Magnesium Hydroxide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Cat's Claw or Aluminum Hydroxide, Aspirin, Magnesium Hydroxide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Aluminum Hydroxide, Aspirin, Magnesium Hydroxide

This page covers Cat's Claw only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aluminum Hydroxide, Aspirin, Magnesium Hydroxide page lists 255 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 211 moderate · 37 minor.

From our pharmacist’s overview on the Aluminum Hydroxide, Aspirin, Magnesium Hydroxide page

“Ascriptin combines aspirin with two antacids, aluminum hydroxide and magnesium hydroxide, and the aspirin part already thins the blood on its own. That is why more than 200 of the 255 ingredients listed here can raise bleeding risk, and why this page deserves a careful read rather than a quick skim.”

Reviewed by 2 · Jul 18, 2026

Open the Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interaction page

One more smart check

Taking Cat's Claw as Part of a Dietary Supplement Product? Check It for Interactions

We hold 910 real supplement products containing Cat's Claw, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cat's Claw. Your product may carry other ingredients that interact with Aluminum Hydroxide, Aspirin, Magnesium Hydroxide too, on top of Cat's Claw — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cat's Claw and Aluminum Hydroxide, Aspirin, Magnesium Hydroxide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cat's Claw
Top 25%

#182 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aluminum Hydroxide, Aspirin, Magnesium Hydroxide
Top 5%

#42 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cat's Claw

What is Cat's Claw?

Cat's Claw
  • Osteoarthritis and rheumatoid arthritis
  • Inflammation
  • Immune support
  • Digestive complaints
  • General wellness/tonic

Cat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support. Some small studies hint it may help with arthritis symptoms, but the overall evidence is limited and not strong enough to confirm clear benefits. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Read the full Cat's Claw monograph & all interactions
Medication

About Aspirin

What Is Aspirin Used For?

Brand name: Ascriptin

Aspirin is used to temporarily relieve minor aches and pains from headaches, backaches, muscle aches, toothaches, menstrual cramps, the common cold, and minor arthritis pain. It also temporarily reduces fever.

Some coated aspirin tablet products note that, under a doctor's supervision, aspirin can help prevent another heart attack or stroke in adults who have already had one. Because of their delayed-release design, those coated products will not give fast relief for headaches or other symptoms needing quick relief.

See full Aspirin drug information Aspirin NDC codes and packages
Keep checking

Other Drugs & Cat's Claw

Browse every other medication we’ve checked against Cat's Claw — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
963Moderate
0Minor
1,866No known interaction
963 Moderate 1,866 No interaction
Moderate

963 interactions

Showing 60 of 963 moderate interactions — see all 963 on the Cat's Claw page.

No interaction 1,866 drugs checked — show the list

We also checked Cat's Claw against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,866 medications checked with no known interaction — see the full Cat's Claw list.

See the full Cat's Claw interactions page
See every supplement checked against Aluminum Hydroxide, Aspirin, Magnesium Hydroxide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cat's Claw monograph › Uses, safety, and every drug interaction in one place Aluminum Hydroxide, Aspirin, Magnesium Hydroxide supplement interactions › Every supplement checked against Aluminum Hydroxide, Aspirin, Magnesium Hydroxide, ranked by severity Aspirin drug information › The full plain-English guide to this medication Aspirin NDC codes and packages › Every package, labeler and price in the FDA directory Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cat's Claw and Aluminum Hydroxide, Aspirin, Magnesium Hydroxide Together: Common Questions

Can you take Cat's Claw with Aluminum Hydroxide, Aspirin, Magnesium Hydroxide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Cat's Claw and Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Aluminum Hydroxide, Aspirin, Magnesium Hydroxide and Cat's Claw?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.