Drug & supplement interaction

Ceylon Cinnamon + Ibuprofen

Ibuprofen brand names: Motrin, Children's Motrin, Advil, Children's Advil, Fenbid Forte Gel, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Ceylon Cinnamon and Ibuprofen in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Ceylon Cinnamon and Ibuprofen

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ibuprofen and Ceylon Cinnamon in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ceylon Cinnamon safety at a glance

Ceylon Cinnamon overall Use caution Generally safe as a food spice, but supplement-strength doses are less studied.
Pregnancy Likely Safe When consumed in amounts commonly found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of Ceylon cinnamon in amounts greater th... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ibuprofen and Ceylon Cinnamon? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ibuprofen

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ibuprofen is filed under 10 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), cytochrome p450 2c9 (cyp2c9) substrates, anticoagulant/antiplatelet drugs. Ceylon Cinnamon has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and antihypertensive drugs (moderate) — and none of Ibuprofen’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ceylon Cinnamon Does Interact With Other Medications

Ceylon Cinnamon has 258 moderate known drug interactions in our database — Ibuprofen isn’t one of them. If you take anything else, check it against the full list below.

Moderate 258 No known interaction 2,572 (incl. Ibuprofen)
Taking anything else?

Check Another of Your Medications Against Ceylon Cinnamon

Covers the 2,830 medications we’ve checked against Ceylon Cinnamon. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Ceylon Cinnamon and Ibuprofen May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    Ceylon Cinnamon

    “While there is concern about the coumarin content in cassia cinnamon increasing the risk for hepatic adverse effects and bleeding, the amount of coumarin in Ceylon cinnamon is negligible and unlikely to cause toxic effects.”

    Ceylon Cinnamon · Natural Medicines adverse-effect record, reported in hepatitis.

    4 sources cited
    1. 89652. Ranasinghe P, Jayawardena R, Galappaththy P, et al. Response to Akilen et al. Efficacy and safety of 'true' cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med 2013 Apr;30(4):506-7.
    2. 92072. Ranasinghe P, Pigera S, Premakumara GA, et al. Medicinal properties of 'true' cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complement Altern Med 2013;13:275. PubMed
    3. 92073. Ranasinghe P, Galappaththy P. Health benefits of Ceylon cinnamon (Cinnamomum zeylanicum): a summary of the current evidence. Ceylon Med J 2016;61(1):1-5. PubMed
    4. 97249. Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed

    Ibuprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ibuprofen. Read the label on DailyMed ›

  • Bleeding or bruising Worth acting on Additional detail

    Ceylon Cinnamon

    “Orally, a case of postoperative hemorrhage is reported in a 49-year-old patient after taking Ceylon cinnamon 1 tablespoon daily for 10 months. One day post-colectomy, the patient had an INR of 1.59 and intraabdominal bleeding that required exploratory laparotomies, blood transfusion, and fresh frozen plasma. Ultimately, the patient was discharged.”

    Ceylon Cinnamon · Natural Medicines adverse-effect record, reported in bleeding.

    1 source cited
    1. 112421. Chase C, Doyle A, John SS, Laurent T, Griffith S. Post-operative haemorrhage secondary to cinnamon use. A case report. Int J Surg Case Rep 2022;95:107179. PubMed

    Ibuprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ibuprofen. Read the label on DailyMed ›

  • Bloating or gas / Nausea reported in 6.5% of FDA reports for Ibuprofen Additional detail

    Ceylon Cinnamon

    “Orally, gastrointestinal side effects such as heartburn, nausea, bloating, and dyspepsia have been reported.”

    Ceylon Cinnamon · Natural Medicines adverse-effect record, reported in dyspepsia.

    1 source cited
    1. 97250. Ranasinghe P, Jayawardena R, Pigera S, et al. Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial. BMC Complement Altern Med 2017;17(1):550. PubMed

    Ibuprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ibuprofen, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Vomiting reported in 4.6% of FDA reports for Ibuprofen Additional detail

    Ceylon Cinnamon

    Recorded for Ceylon Cinnamon in the same Natural Medicines adverse-effect record shown under Liver problems above.

    Ibuprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ibuprofen, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Ceylon Cinnamon but not commonly for Ibuprofen: stomach pain, a skin rash, stomach upset and heartburn.

Effects for Ibuprofen come from the ADVERSE REACTIONS section of its FDA label; effects for Ceylon Cinnamon come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 283,500 voluntary FDA FAERS reports for Ibuprofen that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Ceylon Cinnamon in Pregnancy & Breastfeeding

Pregnancy Likely Safe

When consumed in amounts commonly found in foods.

Pregnancy Likely Unsafe

When used orally in amounts greater than those found in foods. Fetal abnormalities have been reported in animals.

Lactation Likely Safe

When consumed in amounts commonly found in foods. There is insufficient reliable information available about the safety of Ceylon cinnamon in amounts greater than those found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Ibuprofen Is Prescribed For, and What Ceylon Cinnamon Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Ibuprofen is a prescription medicine with approved uses on its FDA label. Ceylon Cinnamon is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Ibuprofen is prescribed for: Oral ibuprofen products (tablets, coated tablets, and liquid-filled capsules) are used to temporarily relieve minor aches and pains from headache, backache, toothache, muscular aches, menstrual cramps, minor arthritis pain, and the common cold, and to temporarily reduce fever. The oral prescription tablet (Ibu) is also indicated for the signs and symptoms of rheumatoid arthritis and osteoarthritis, mild to moderate pain, and primary dysmenorrhea (painful periods). Caldolor, an intravenous (IV) form, is approved for adults and children 3 months and older to manage mild to moderate pain, to manage moderate to severe pain alongside opioid pain medicines, and to reduce fever. A separate intravenous solution, Ibuprofen Lysine, is used specifically in premature infants to close a patent ductus arteriosus (PDA) — an abnormal blood vessel connection near the heart — when standard medical management has not worked.

Ceylon Cinnamon has been studied for:

  • Dysmenorrhea studied, not established Ceylon Cinnamon has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Ceylon Cinnamon for dysmenorrhea

    It is unclear if oral Ceylon cinnamon is beneficial in patients with dysmenorrhea.

  • Common cold studied, not established Ceylon Cinnamon has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Ceylon Cinnamon for common cold

    Although there has been interest in using oral Ceylon cinnamon for the common cold, there is insufficient reliable information about the clinical effects of Ceylon cinnamon for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Ibuprofen on your own; if you are taking Ceylon Cinnamon for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Ceylon Cinnamon or Ibuprofen

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ceylon Cinnamon or Ibuprofen, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ibuprofen

This page covers Ceylon Cinnamon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ibuprofen page lists 286 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 243 moderate · 36 minor.

From our pharmacist’s overview on the Ibuprofen page

“Most people treat ibuprofen (Advil, Motrin) as an everyday pain reliever, which is exactly why this list of 286 interacting supplements deserves real attention rather than a shrug. The dominant pattern by far is bleeding: 202 of these ingredients can add to the bleeding and stomach irritation ibuprofen already causes, and the seven maj…”

Reviewed by 2 · Jul 18, 2026

Open the Ibuprofen interaction page

One more smart check

Taking Ceylon Cinnamon as Part of a Dietary Supplement Product? Check It for Interactions

We hold 362 real supplement products containing Ceylon Cinnamon, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ceylon Cinnamon. Even though Ceylon Cinnamon itself has no known interaction with Ibuprofen, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ceylon Cinnamon and Ibuprofen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ceylon Cinnamon
Top 25%

#322 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ibuprofen
Top 1%

#19 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ceylon Cinnamon reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ceylon Cinnamon and Ibuprofen records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ceylon Cinnamon

What is Ceylon Cinnamon?

Ceylon Cinnamon
  • Blood sugar support
  • High cholesterol
  • Indigestion and gas
  • Antimicrobial
  • General flavoring and culinary use

Ceylon cinnamon is the so-called 'true' cinnamon, valued as a spice and used in traditional medicine for blood sugar, cholesterol, and digestion. Evidence for most health benefits is limited and mixed, but as a food it is generally safe and contains far less coumarin than common cassia cinnamon. Talk with your pharmacist or doctor before taking concentrated supplements, especially if you have a health condition or take medications.

Cinnamomum verum · Lauraceae · Inner bark (and bark-derived essential oil) · Ground spice, capsules, powder, extracts, tea, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Ceylon Cinnamon is a good idea for someone in your situation. Here is what our Ceylon Cinnamon record says about it on its own.

Ceylon Cinnamon: dosing

There is no official, standardized dose of Ceylon cinnamon for any health condition. Amounts used in studies have varied widely, and many studies used cassia cinnamon, so results may not apply to Ceylon products.If you choose to take a supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Ceylon Cinnamon monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ceylon Cinnamon monograph & all interactions
Medication

About Ibuprofen

What Is Ibuprofen Used For?

Brand names: Motrin, Children's Motrin, Advil, Children's Advil, Fenbid Forte Gel, Ibugel Forte, Arthrofen, Ebufac, Rimafen, Calprofen, Fenpaed, Galprofen, Nurofen for Children, Orbifen for Children, Brufen, Brufen Retard, Fenbid, Tab-Profen, Ibuprofen, Calodor

Oral ibuprofen products (tablets, coated tablets, and liquid-filled capsules) are used to temporarily relieve minor aches and pains from headache, backache, toothache, muscular aches, menstrual cramps, minor arthritis pain, and the common cold, and to temporarily reduce fever. The oral prescription tablet (Ibu) is also indicated for the signs and symptoms of rheumatoid arthritis and osteoarthritis, mild to moderate pain, and primary dysmenorrhea (painful periods).

Caldolor, an intravenous (IV) form, is approved for adults and children 3 months and older to manage mild to moderate pain, to manage moderate to severe pain alongside opioid pain medicines, and to reduce fever. A separate intravenous solution, Ibuprofen Lysine, is used specifically in premature infants to close a patent ductus arteriosus (PDA) — an abnormal blood vessel connection near the heart — when standard medical management has not worked.

Most-Reported Side Effects for Ibuprofen

From FAERS, the FDA’s public side-effect reporting system (283,500 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 18,755 reports
Nausea 18,290 reports
Headache 16,566 reports
Arthralgia 13,469 reports
Dyspnea 13,139 reports
See full Ibuprofen drug information
Keep checking

Other Drugs & Ceylon Cinnamon

Browse every other medication we’ve checked against Ceylon Cinnamon — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
258Moderate
0Minor
2,571No known interaction
258 Moderate 2,571 No interaction
Moderate

258 interactions

Showing 60 of 258 moderate interactions — see all 258 on the Ceylon Cinnamon page.

No interaction 2,571 drugs checked — show the list

We also checked Ceylon Cinnamon against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,571 medications checked with no known interaction — see the full Ceylon Cinnamon list.

See the full Ceylon Cinnamon interactions page
See every supplement checked against Ibuprofen, ranked by severity
Evidence & sources

Ceylon Cinnamon References

The 22 references that drive our Ceylon Cinnamon monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Choi HK, Jung GW, Moon KH, et al. Clinical study of SS-Cream in patients with lifelong premature ejaculation. Urology 2000;55:257-61. PubMed
  4. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  5. Anderson RA, Broadhurst CL, Polansky MM, et al. Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like Biological Activity. J Agric Food Chem 2004;52:65-70. PubMed
  6. Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 2001;20:327-36. PubMed
  7. Onderoglu S, Sozer S, Erbil KM, et al. The evaluation of long-term effcts of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats. J Pharm Pharmacol 1999;51:1305-12.
  8. Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
  9. Ranasinghe P, Jayawardena R, Galappaththy P, et al. Response to Akilen et al. Efficacy and safety of 'true' cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med 2013 Apr;30(4):506-7.
  10. Oliveira JdA, da Silva IC, Trindade LA, et al. Safety and tolerability of essential oil from Cinnamomum zeylanicum blume leaves with action on oral candidosis and its effect on the physical properties of the acylic resin. Evid Based Complement Alternat Me
  11. Ranasinghe P, Pigera S, Premakumara GA, et al. Medicinal properties of 'true' cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complement Altern Med 2013;13:275. PubMed
  12. Ranasinghe P, Galappaththy P. Health benefits of Ceylon cinnamon (Cinnamomum zeylanicum): a summary of the current evidence. Ceylon Med J 2016;61(1):1-5. PubMed
  13. Nyadjeu P, Dongmo A, Nguelefack TB, Kamanyi A. Antihypertensive and vasorelaxant effects of Cinnamomum zeylanicum stem bark aqueous extracts. J Complement Integr Med 2011;8.
  14. Wansi SL, Nyadjeu P, Ngamga D, et al. Blood pressure lowering effect of the ethanol extract from the stembark of Cinnamomum zeylanicum (lauraceae) in rats. Pharmacol online 2007;3:166-76.
  15. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ceylon Cinnamon and Ibuprofen Together: Common Questions

Is it safe to take Ceylon Cinnamon with Ibuprofen?
We do not list a known interaction between Ceylon Cinnamon and Ibuprofen. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Ceylon Cinnamon and Ibuprofen have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Ceylon Cinnamon and Ibuprofen used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Ceylon Cinnamon in each. That is a conversation for your prescriber, especially if Ibuprofen is being adjusted to a target.
How was the Ceylon Cinnamon and Ibuprofen combination checked?
Interactions in our licensed database are recorded against drug classes. Ibuprofen is filed under 10 classifications, and Ceylon Cinnamon has documented interactions with 2 drug classes — none of Ibuprofen's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Ceylon Cinnamon interact with any other medications?
Yes. Ceylon Cinnamon has 258 documented drug interactions in our database — Ibuprofen is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ibuprofen interact with any supplements?
Yes. Ibuprofen has documented interactions with 286 supplements in our database — Ceylon Cinnamon is not one of them. The Ibuprofen interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ceylon Cinnamon monograph Uses, safety profile, and every drug interaction in one place Ibuprofen drug information The full plain-English guide to this medication Ibuprofen supplement interactions Every supplement checked against Ibuprofen, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 22 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ibuprofen and Ceylon Cinnamon?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.