Drug & supplement interaction

Chaulmoogra + Hydroxyzine

Hydroxyzine brand names: Atarax, Vistaril, Ucerax.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Chaulmoogra and Hydroxyzine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Chaulmoogra and Hydroxyzine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hydroxyzine and Chaulmoogra in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Chaulmoogra at all — not against Hydroxyzine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chaulmoogra safety at a glance

Chaulmoogra overall Use caution Largely outdated remedy with limited modern safety data and a history of irritation and side effects.
Pregnancy Avoid Not enough safety information; avoid during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hydroxyzine and Chaulmoogra? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Chaulmoogra Itself Has Been Linked To

This is not an interaction — nothing below involves Hydroxyzine. It is the side-effect record for Chaulmoogra on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Chaulmoogra, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Kidney problems / Shortness of breath Worth acting on Additional detail

    “Orally, ingestion of the seed can cause cough, dyspnea, laryngospasms, nephrotoxicity, visual disorders, head and muscle pain, and central paralysis (18).

    Topically, use can cause skin irritation (18).”

    Chaulmoogra · Natural Medicines adverse-effect record, reported in cough.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Cough / Muscle pain Additional detail

    Recorded for Chaulmoogra in the same Natural Medicines adverse-effect record shown under Kidney problems / Shortness of breath above.

Everything above comes from the Natural Medicines adverse-effect record for Chaulmoogra — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Hydroxyzine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Hydroxyzine column appears here.

From our Q&A

Questions About Chaulmoogra or Hydroxyzine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Chaulmoogra or Hydroxyzine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Hydroxyzine

This page covers Chaulmoogra only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydroxyzine page lists 183 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Henbane (major), Scopolia (major) and St. John's Wort (major).

By severity: 5 major · 135 moderate · 43 minor.

From our pharmacist’s overview on the Hydroxyzine page

“Hydroxyzine (Atarax, Vistaril) is a sedating antihistamine for itching and anxiety, so read this list closely before pairing it with any supplement. Five of the 183 ingredients on file rate major, and those come first: grapefruit and St.”

Reviewed by 2 · Jul 18, 2026

Open the Hydroxyzine interaction page

How much people look this up

Where Chaulmoogra and Hydroxyzine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chaulmoogra
Steady interest

#1,122 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydroxyzine
Top 25%

#397 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chaulmoogra reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chaulmoogra and Hydroxyzine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chaulmoogra

What is Chaulmoogra?

  • Leprosy (historical)
  • Skin conditions and rashes
  • Wound and sore care
  • Eczema and psoriasis (traditional)
  • Rheumatic complaints (traditional)

Chaulmoogra oil is an old herbal remedy famous for being the main treatment for leprosy before modern antibiotics. Today it has been replaced by safer, more effective drugs, and there is little reliable modern evidence to support its use. If you are considering it, talk to a pharmacist or doctor first, and avoid it during pregnancy and breastfeeding.

Hydnocarpus kurzii · Achariaceae · Seed oil (chaulmoogra oil) and seeds · Seed oil, topical preparations, and historically injectable oil derivatives

An interaction check asks whether these two react with each other — it does not ask whether Chaulmoogra is a good idea for someone in your situation. Here is what our Chaulmoogra record says about it on its own.

Chaulmoogra: dosing

There is no established, standardized dose for chaulmoogra in modern use, and it is not a recommended treatment today. Historical doses varied widely and were used under medical supervision in an era before modern drugs.If you find a product that contains chaulmoogra, follow the directions on the label and do not use it internally.

From our Chaulmoogra monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chaulmoogra monograph & all interactions
Medication

About Hydroxyzine

What Is Hydroxyzine Used For?

Brand names: Atarax, Vistaril, Ucerax

Hydroxyzine is used to relieve anxiety and tension related to psychoneurosis (anxiety-based mental health conditions) and as a supportive treatment when anxiety is part of another medical condition. Oral forms — including tablets, capsules, and oral solution — are used for anxiety relief and to manage itching (pruritus) caused by allergic conditions such as chronic urticaria (hives), atopic dermatitis, contact dermatitis, and histamine-driven itch. Oral forms are also used as a sedative before and after surgery or general anesthesia.

Hydroxyzine Hydrochloride intramuscular injection is used specifically when a shot is needed — for example, in acute psychiatric or emotional emergencies, acute alcohol withdrawal with anxiety symptoms or delirium tremens, control of nausea and vomiting (except during pregnancy), and as pre- and post-operative or pre- and post-partum supportive medication to reduce narcotic requirements and control nausea.

Most-Reported Side Effects for Hydroxyzine

From FAERS, the FDA’s public side-effect reporting system (50,845 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Pruritus 3,383 reports
Nausea 3,067 reports
Fatigue 2,961 reports
Toxicity to various agents 2,567 reports
Completed suicide 2,544 reports
See full Hydroxyzine drug information
Keep checking

Other Drugs & Chaulmoogra

Browse every other medication we’ve checked against Chaulmoogra — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Chaulmoogra against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Chaulmoogra list.

See the full Chaulmoogra interactions page
See every supplement checked against Hydroxyzine, ranked by severity
Evidence & sources

Chaulmoogra References

The 1 references that drive our Chaulmoogra monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chaulmoogra and Hydroxyzine Together: Common Questions

Is it safe to take Chaulmoogra with Hydroxyzine?
We do not list a known interaction between Chaulmoogra and Hydroxyzine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Hydroxyzine interact with any supplements?
Yes. Hydroxyzine has documented interactions with 183 supplements in our database — Chaulmoogra is not one of them. The Hydroxyzine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chaulmoogra monograph Uses, safety profile, and every drug interaction in one place Hydroxyzine drug information The full plain-English guide to this medication Hydroxyzine supplement interactions Every supplement checked against Hydroxyzine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Hydroxyzine and Chaulmoogra?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.