Hydroxyzine

87 interactions 5 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Olodaterol Oral Inhalation Cetirizine Injection Deutetrabenazine Glycopyrronium Topical Moxifloxacin Injection Metoclopramide Nasal Spray

86 Major 1 Moderate

All (87) Major (86) Moderate (1)

Major

Hydroxyzine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Hydroxyzine Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Hydroxyzine Sertraline Explained An increased risk of QT interval prolongation Details Hydroxyzine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, an increased risk of CNS and respiratory depression and an increased risk of paraly... Details Hydroxyzine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Hydroxyzine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Hydroxyzine Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Hydroxyzine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Hydroxyzine Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Hydroxyzine Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Hydroxyzine Azithromycin AzaSite An increased risk of QT interval prolongation Details Hydroxyzine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Hydroxyzine Anagrelide Agrylin An increased risk of QT interval prolongation Details Hydroxyzine Bedaquiline Sirturo An increased risk of QT interval prolongation Details Hydroxyzine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Hydroxyzine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Hydroxyzine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Hydroxyzine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Hydroxyzine Chloroquine Aralen® An increased risk of QT interval prolongation Details Hydroxyzine Dasatinib Phyrago An increased risk of QT interval prolongation Details Hydroxyzine Degarelix Injection Firmagon An increased risk of QT interval prolongation Details Hydroxyzine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Hydroxyzine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Hydroxyzine Diazepam Rectal Diastat Increased risk of CNS depression Details Hydroxyzine Disopyramide Norpace An increased risk of QT interval prolongation Details Hydroxyzine Dofetilide Tikosyn An increased risk of QT interval prolongation Details Hydroxyzine Dolasetron Anzemet An increased risk of QT interval prolongation Details Hydroxyzine Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Hydroxyzine Encorafenib Braftovi Increased risk of QT interval prolongation Details Hydroxyzine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Hydroxyzine Eribulin Injection Halaven An increased risk of QT interval prolongation Details Hydroxyzine Esketamine Nasal Spray Spravato Increased risk of sedation Details Hydroxyzine Famotidine Calmicid An increased risk of QT interval prolongation Details Hydroxyzine Famotidine Injection Calmicid An increased risk of QT interval prolongation Details Hydroxyzine Felbamate Felbatol An increased risk of QT interval prolongation Details Hydroxyzine Fentanyl Transdermal Patch Duragesic® Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Hydroxyzine Flecainide Tambocor® An increased risk of QT interval prolongation Details Hydroxyzine Foscarnet Injection Foscavir An increased risk of QT interval prolongation Details Hydroxyzine Fostemsavir Rukobia Increased risk of torsade de pointes Details Hydroxyzine Galantamine Razadyne An increased risk of QT interval prolongation Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.