Drug & supplement interaction

Beet + Hydroxyzine

Hydroxyzine brand names: Atarax, Vistaril, Ucerax.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Beet has a moderate interaction with Hydroxyzine. Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Beet and Hydroxyzine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

Why this applies to Hydroxyzine

Hydroxyzine falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group Beet interacts with.

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for beets and hydroxyzine. Your body uses an enzyme called CYP3A4 to help clear hydroxyzine. Lab studies (in test tubes, not people) hint that betanin, the red pigment in beets, may slow that enzyme down a bit. If that happened in real life, hydroxyzine could linger longer and feel stronger, meaning more drowsiness, dry mouth, or a groggy, foggy feeling.

Now the reassuring part: this is only theoretical, based on very early lab work, and eating beets or drinking some beet juice almost certainly won't cause trouble. I'd be a little more thoughtful with concentrated beet supplements. If you notice extra sleepiness, just loop in your pharmacist or doctor before changing anything.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Lim SH, Bae S, Lee HS, Han HK, Choi CI. Effect of Betanin, the Major Pigment of Red Beetroot (Beta vulgaris L.), on the Activity of Recombinant Human Cytochrome P450 Enzymes. Pharmaceuticals (Basel) 2023;16(9):1224. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Beet Also Interacts With Other Medications

Beet has 644 moderate, 218 minor known drug interactions in our database — the Hydroxyzine one above is one of them. If you take anything else, check it against the full list below.

Moderate 644 Minor 218 No known interaction 1,968 (incl. Hydroxyzine)
Taking anything else?

Check Another of Your Medications Against Beet

Covers the 2,830 medications we’ve checked against Beet. Pick one to open its full report.

From our Q&A

Questions About Beet or Hydroxyzine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Beet or Hydroxyzine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Hydroxyzine

This page covers Beet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydroxyzine page lists 183 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Henbane (major), Scopolia (major) and St. John's Wort (major).

By severity: 5 major · 135 moderate · 43 minor.

From our pharmacist’s overview on the Hydroxyzine page

“Hydroxyzine (Atarax, Vistaril) is a sedating antihistamine for itching and anxiety, so read this list closely before pairing it with any supplement. Five of the 183 ingredients on file rate major, and those come first: grapefruit and St.”

Reviewed by 2 · Jul 18, 2026

Open the Hydroxyzine interaction page

One more smart check

Taking Beet as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,786 real supplement products containing Beet, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Beet. Your product may carry other ingredients that interact with Hydroxyzine too, on top of Beet — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Beet and Hydroxyzine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Beet
Top 5%

#39 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydroxyzine
Top 25%

#577 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Beet

What is Beet?

Beet
  • High blood pressure
  • Exercise and athletic performance
  • Heart and circulation support
  • General antioxidant/anti-inflammatory support
  • Liver and digestive support

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but supplement effects are modest and not a substitute for prescribed treatment, so talk with your pharmacist or doctor before relying on it.

Read the full Beet monograph & all interactions
Medication

About Hydroxyzine

What Is Hydroxyzine Used For?

Brand names: Atarax, Vistaril, Ucerax

Hydroxyzine by mouth (tablets, capsules, oral solution and syrup) is used for short-term relief of anxiety and tension linked to psychoneurosis (long-standing anxiety-type emotional conditions). It is also used when anxiety is part of another physical illness.

It helps with itching from allergic conditions such as chronic urticaria (hives) and atopic and contact dermatoses (eczema-type and irritant or allergic skin rashes). It is also used as a sedative before and after general anesthesia. Hydroxyzine hydrochloride intramuscular injection has additional uses, including acutely disturbed patients, alcohol withdrawal anxiety, delirium tremens, nausea and vomiting (not pregnancy-related), and as an add-on around surgery and childbirth.

See full Hydroxyzine drug information
Keep checking

Other Drugs & Beet

Browse every other medication we’ve checked against Beet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
644Moderate
218Minor
1,967No known interaction
644 Moderate 218 Minor 1,967 No interaction
Moderate

644 interactions

Showing 60 of 644 moderate interactions — see all 644 on the Beet page.

Minor

218 interactions

Showing 60 of 218 minor interactions — see all 218 on the Beet page.

No interaction 1,967 drugs checked — show the list

We also checked Beet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,967 medications checked with no known interaction — see the full Beet list.

See the full Beet interactions page
See every supplement checked against Hydroxyzine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Beet monograph › Uses, safety, and every drug interaction in one place Hydroxyzine supplement interactions › Every supplement checked against Hydroxyzine, ranked by severity Hydroxyzine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Beet and Hydroxyzine Together: Common Questions

Can you take Beet with Hydroxyzine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Beet and Hydroxyzine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Hydroxyzine and Beet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.