Drug & supplement interaction

Chelation Therapy Products + Levetiracetam

Levetiracetam brand names: Keppra, Elepsia XR, Spritam.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Chelation Therapy Products and Levetiracetam in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Chelation Therapy Products and Levetiracetam

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Levetiracetam and Chelation Therapy Products in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chelation Therapy Products safety at a glance

Chelation Therapy... overall Use caution Real chelation is a medical treatment that needs supervision; OTC 'chelation' products are unproven and risky.
Pregnancy Possibly Unsafe When unregulated chelation therapy products are used orally or parentally or when prescription chelation therapy products are used for unproven indications and/... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When unregulated chelation therapy products are used orally or parentally or when prescription chelation therapy products are used for unproven indications and/... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Levetiracetam and Chelation Therapy Products? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Levetiracetam

Interactions in our licensed database are recorded against drug classes, not just single drug names. Levetiracetam is filed under 3 classifications — anticonvulsants, cns depressants, oral drugs. Chelation Therapy Products has documented interactions with 3 drug classes — the most serious being insulin (major), diuretic drugs (moderate) and warfarin (coumadin) (moderate) — and none of Levetiracetam’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Chelation Therapy Products Does Interact With Other Medications

Chelation Therapy Products has 13 major, 77 moderate known drug interactions in our database — Levetiracetam isn’t one of them. If you take anything else, check it against the full list below.

Major 13 Moderate 77 No known interaction 2,740 (incl. Levetiracetam)
Taking anything else?

Check Another of Your Medications Against Chelation Therapy Products

Covers the 2,830 medications we’ve checked against Chelation Therapy Products. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Chelation Therapy Products and Levetiracetam May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

  • A severe skin reaction Worth acting on Additional detail

    Chelation Therapy Products

    “There is a case report of Stevens-Johnson syndrome after two weeks of oral 2,3-dimercaptopropane-1-sulfonate (DMPS) chelation therapy in a child with chronic mercury exposure. Symptoms included a widespread eruption of red, itchy macules which gradually improved after discontinuation of DMPS therapy.”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in dermatitis.

    5 sources cited
    1. 108112. Van der Linde AAA, Pillen S, Gerrits GPJM, Bouwes Bavinck JN. Stevens-Johnson syndrome in a child with chronic mercury exposure and 2,3-dimercaptopropane-1-sulfonate (DMPS) therapy. Clin Toxicol (Phila). 2008;46(5):479-81. PubMed
    2. 108099. James S, Stevenson SW, Silove N, Williams K. Chelation for autism spectrum disorder (ASD). Cochrane Database Syst Rev 2015;5(5):CD010766. PubMed
    3. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    4. 108103. Villarruz MV, Dans A, Tan F. Chelation therapy for atherosclerotic cardiovascular disease. Cochrane Database Syst Rev 2002;(4):CD002785. PubMed
    5. 5744. Christensen K, Theilade D. Edta chelation therapy: an ethical problem. Med Hypotheses 1999;53:69-70. PubMed

    Levetiracetam

    Listed in the ADVERSE REACTIONS section of the FDA label for Levetiracetam. Read the label on DailyMed ›

  • Seizures Worth acting on Additional detail

    Chelation Therapy Products

    “Intravenously, calcium disodium ethylenediamene tetraacetic acid (EDTA) can cause zinc deficiency and hypercalcemia. Disodium EDTA can occasionally reduce magnesium and potassium serum concentrations, and rarely cause insulin shock.

    Disodium EDTA, when given as a rapid infusion or highly concentrated solution, can cause hypocalcemia, leading to tetany, convulsions, cardiac arrhythmias, cardiac failure, respiratory ar…”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in arrhythmia.

    6 sources cited
    1. 5771. Lacy CF, Armstrong LL, Ingrim NB, et al. Drug Information Handbook. 6th ed. Hudson, OH:Lexi-Comp Inc 1998:439-41.
    2. 5772. Ellsworth AJ, Witt DM, Dugdale DC, et al. Medical Drug Reference. Saint Louis, MO: Mosby-Year Book Inc 1998:302-3.
    3. 5737. Grier MT, Meyers DG. So much writing, so little science: a review of 37 years literature on edetate sodium chelation therapy. Ann Pharmacother 1993;27:1504-9.
    4. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    5. 94984. Fountain JS, Reith DM. Dangers of "EDTA". N Z Med J 2014;127:126-7.
    6. 94985. Lamas GA, Goertz C, Boineau R, et al. Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. JAMA 2013;309:1241-50. PubMed

    Levetiracetam

    Listed in the ADVERSE REACTIONS section of the FDA label for Levetiracetam. Read the label on DailyMed ›

  • An allergic reaction Worth acting on Additional detail

    Chelation Therapy Products

    “Intravenously, disodium ethylenediamene tetraacetic acid (EDTA) can rarely cause histamine-like reactions. There are rare reports of allergic reactions to EDTA given as a nasal provocation, topically, intradermally, and subcutaneously.”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    3 sources cited
    1. 5737. Grier MT, Meyers DG. So much writing, so little science: a review of 37 years literature on edetate sodium chelation therapy. Ann Pharmacother 1993;27:1504-9.
    2. 94992. Russo PA, Banovic T, Wiese MD, et al. Systemic allergy to EDTA in local anesthetic and radiocontrast media. J Allergy Clin Immunol Pract 2014;2:225-9. PubMed
    3. 108105. Wax PM. Current use of chelation in American health care. J Med Toxicol 2013;9(4):303-7. PubMed

    Levetiracetam

    Listed in the ADVERSE REACTIONS section of the FDA label for Levetiracetam. Read the label on DailyMed ›

  • Numbness or tingling / Headache Additional detail

    Chelation Therapy Products

    “Intravenously, ethylenediamene tetraacetic acid (EDTA) can commonly cause headache and faintness (15,108103). EDTA can also sometimes cause fever, chills, fatigue, and malaise (15,108099). Disodium EDTA can occasionally cause tremors, tingling, and paresthesias (15).

    Orally, dimercaptosuccinic acid (DMSA) was associated with lethargy in one child in a clinical trial.”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in cluster headache.

    3 sources cited
    1. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    2. 108103. Villarruz MV, Dans A, Tan F. Chelation therapy for atherosclerotic cardiovascular disease. Cochrane Database Syst Rev 2002;(4):CD002785. PubMed
    3. 108099. James S, Stevenson SW, Silove N, Williams K. Chelation for autism spectrum disorder (ASD). Cochrane Database Syst Rev 2015;5(5):CD010766. PubMed

    Levetiracetam

    Listed in the ADVERSE REACTIONS section of the FDA label for Levetiracetam. Read the label on DailyMed ›

  • Reduced appetite Additional detail

    Chelation Therapy Products

    “Intravenously, ethylenediamene tetraacetic acid (EDTA) can commonly cause abdominal cramps, anorexia, nausea, vomiting, and diarrhea (15). EDTA can also sometimes cause thirst (15).

    When given orally or intravenously, 2,3-dimercaptopropane-1-sulfonate (DMPS) has caused nausea and dysgeusia.

    Orally, dimercaptosuccinic acid (DMSA) has caused gastrointestinal upset and diminished appetite.”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in anorexia.

    2 sources cited
    1. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    2. 108099. James S, Stevenson SW, Silove N, Williams K. Chelation for autism spectrum disorder (ASD). Cochrane Database Syst Rev 2015;5(5):CD010766. PubMed

    Levetiracetam

    Listed in the ADVERSE REACTIONS section of the FDA label for Levetiracetam. Read the label on DailyMed ›

  • Tiredness Additional detail

    Chelation Therapy Products

    Recorded for Chelation Therapy Products in the same Natural Medicines adverse-effect record shown under Numbness or tingling / Headache above.

    Levetiracetam

    Listed in the ADVERSE REACTIONS section of the FDA label for Levetiracetam. Read the label on DailyMed ›

Reported for Chelation Therapy Products but not commonly for Levetiracetam: stomach upset, a heart attack, an irregular heartbeat and stomach pain.

Effects for Levetiracetam come from the ADVERSE REACTIONS section of its FDA label; effects for Chelation Therapy Products come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Chelation Therapy Products in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When unregulated chelation therapy products are used orally or parentally or when prescription chelation therapy products are used for unproven indications and/or in unapproved doses or routes of administration. The American College of Medical Toxicology and The American Academy of Clinical Toxicology recommend against the unapproved use of chelation therapy products. Chelation therapy products can have teratogenic effects and result in severe side effects including dehydration, hypocalcemia, kidney failure, neurodevelopmental toxicity, and death.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Chelation Therapy Products or Levetiracetam

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Chelation Therapy Products or Levetiracetam, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Levetiracetam

This page covers Chelation Therapy Products only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Levetiracetam page lists 105 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 7 major · 82 moderate · 16 minor.

From our pharmacist’s overview on the Levetiracetam page

“I would read this page carefully rather than casually. Levetiracetam (Keppra, Spritam) controls seizures, and both hazards on this list run through that fact.”

Reviewed by 2 · Jul 18, 2026

Open the Levetiracetam interaction page

How much people look this up

Where Chelation Therapy Products and Levetiracetam Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chelation Therapy Products
Steady interest

#761 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Levetiracetam
Top 5%

#127 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chelation Therapy Products reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chelation Therapy Products and Levetiracetam records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chelation Therapy Products

What is Chelation Therapy Products?

  • Heavy metal poisoning (lead, mercury, arsenic, iron)
  • Marketed for heart and artery health
  • Promoted for 'detoxification'
  • Promoted for circulation problems
  • Sometimes promoted for autism (not supported)

Chelation therapy uses binding agents (like EDTA, DMSA, or DMPS) that latch onto certain metals so the body can remove them. It is an FDA-approved, doctor-supervised treatment only for proven heavy metal poisoning; over-the-counter 'chelation' supplements and unsupervised IV chelation for heart disease or detox are not proven safe or effective and can be dangerous. Talk to your doctor or pharmacist before considering any chelation product.

Not applicable (synthetic and oral binding agents) · Intravenous (IV) infusions, oral capsules, suppositories, and sprays

An interaction check asks whether these two react with each other — it does not ask whether Chelation Therapy Products is a good idea for someone in your situation. Here is what our Chelation Therapy Products record says about it on its own.

Chelation Therapy Products: dosing

There is no safe "do-it-yourself" chelation dose. When chelation is medically needed for poisoning, the agent, dose, and schedule are chosen by a doctor based on the specific metal, blood levels, body weight, and kidney function, with close monitoring.Over-the-counter "chelation" supplements are not standardized, and their actual contents and strength are uncertain. We do not recommend self-dosing these products.If a product label gives directions, do not assume they are safe or effective.

From our Chelation Therapy Products monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chelation Therapy Products monograph & all interactions
Medication

About Levetiracetam

What Is Levetiracetam Used For?

Brand names: Keppra, Elepsia XR, Spritam

Levetiracetam is used to treat several types of seizures. It treats partial-onset seizures (seizures that start in one area of the brain) and is used as add-on therapy for myoclonic seizures (sudden, brief muscle jerks) in people with juvenile myoclonic epilepsy aged 12 and older, and for primary generalized tonic-clonic seizures (grand mal seizures) in people with idiopathic generalized epilepsy aged 6 and older.

Age eligibility varies by product. Keppra oral and Roweepra tablets treat partial-onset seizures in patients as young as 1 month. Spritam and levetiracetam tablets for oral suspension treat partial-onset seizures in patients 4 years and older weighing more than 20 kg. Extended-release products — including Elepsia XR, Keppra XR, and Levetiracetam ER — are approved only for partial-onset seizures in patients 12 years and older. Injectable forms are used intravenously when a patient temporarily cannot take oral medication.

Most-Reported Side Effects for Levetiracetam

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Seizure 15,978 reports
Fatigue 5,591 reports
Somnolence 4,177 reports
Epilepsy 4,136 reports
Convulsion 4,085 reports
See full Levetiracetam drug information
Keep checking

Other Drugs & Chelation Therapy Products

Browse every other medication we’ve checked against Chelation Therapy Products — both the ones with a known interaction and the ones without. Select any drug for the full detail.

13Major
77Moderate
0Minor
2,739No known interaction
13 Major 77 Moderate 2,739 No interaction
Major

13 interactions

Moderate

77 interactions

Showing 60 of 77 moderate interactions — see all 77 on the Chelation Therapy Products page.

No interaction 2,739 drugs checked — show the list

We also checked Chelation Therapy Products against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,739 medications checked with no known interaction — see the full Chelation Therapy Products list.

See the full Chelation Therapy Products interactions page
See every supplement checked against Levetiracetam, ranked by severity
Evidence & sources

Chelation Therapy Products References

The 21 references that drive our Chelation Therapy Products monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Grebe HB, Gregory PJ. Inhibition of warfarin anticoagulation associated with chelation therapy. Pharmacotherapy 2002;22:1067-9.. PubMed
  3. Grier MT, Meyers DG. So much writing, so little science: a review of 37 years literature on edetate sodium chelation therapy. Ann Pharmacother 1993;27:1504-9.
  4. Christensen K, Theilade D. Edta chelation therapy: an ethical problem. Med Hypotheses 1999;53:69-70. PubMed
  5. Lacy CF, Armstrong LL, Ingrim NB, et al. Drug Information Handbook. 6th ed. Hudson, OH:Lexi-Comp Inc 1998:439-41.
  6. Ellsworth AJ, Witt DM, Dugdale DC, et al. Medical Drug Reference. Saint Louis, MO: Mosby-Year Book Inc 1998:302-3.
  7. Fountain JS, Reith DM. Dangers of "EDTA". N Z Med J 2014;127:126-7.
  8. Lamas GA, Goertz C, Boineau R, et al. Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. JAMA 2013;309:1241-50. PubMed
  9. Russo PA, Banovic T, Wiese MD, et al. Systemic allergy to EDTA in local anesthetic and radiocontrast media. J Allergy Clin Immunol Pract 2014;2:225-9. PubMed
  10. Centers for Disease Control and Prevention (CDC). Deaths associated with hypocalcemia from chelation therapy--Texas, Pennsylvania, and Oregon, 2003-2005. MMWR Morb Mortal Wkly Rep 2006;55(8):204-7.
  11. Brown MJ, Willis T, Omalu B, Leiker R. Deaths resulting from hypocalcemia after administration of edetate disodium: 2003-2005. Pediatrics 2006;118(2):e534-6. PubMed
  12. Baxter AJ, Krenzelok EP. Pediatric fatality secondary to EDTA chelation. Clin Toxicol (Phila) 2008;46(10):1083-4. PubMed
  13. Atwood KC, Woeckner E. In pediatric fatality, edetate disodium was no accident. Clin Toxicol (Phila) 2009;47(3):256. PubMed
  14. James S, Stevenson SW, Silove N, Williams K. Chelation for autism spectrum disorder (ASD). Cochrane Database Syst Rev 2015;5(5):CD010766. PubMed
  15. Lamas GA, Hussein SJ. EDTA chelation therapy meets evidence-based medicine. Complement Ther Clin Pract 2006;12(3):213-5. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chelation Therapy Products and Levetiracetam Together: Common Questions

Is it safe to take Chelation Therapy Products with Levetiracetam?
We do not list a known interaction between Chelation Therapy Products and Levetiracetam. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Chelation Therapy Products and Levetiracetam have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Chelation Therapy Products and Levetiracetam combination checked?
Interactions in our licensed database are recorded against drug classes. Levetiracetam is filed under 3 classifications, and Chelation Therapy Products has documented interactions with 3 drug classes — none of Levetiracetam's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Chelation Therapy Products interact with any other medications?
Yes. Chelation Therapy Products has 90 documented drug interactions in our database — Levetiracetam is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Levetiracetam interact with any supplements?
Yes. Levetiracetam has documented interactions with 105 supplements in our database — Chelation Therapy Products is not one of them. The Levetiracetam interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chelation Therapy Products monograph Uses, safety profile, and every drug interaction in one place Levetiracetam drug information The full plain-English guide to this medication Levetiracetam supplement interactions Every supplement checked against Levetiracetam, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 21 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Levetiracetam and Chelation Therapy Products?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.