Medication interaction hub

What Supplements Interact with Levetiracetam?

Levetiracetam brand names: Keppra, Elepsia XR, Spritam. Every interaction below applies to the brands too.

105 Interactions 7 Major 82 Moderate 16 Minor
Curated & coded by · Clinical Pharmacist · Updated October 2, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Levetiracetam? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Levetiracetam against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

I would read this page carefully rather than casually. Levetiracetam (Keppra, Spritam) controls seizures, and both hazards on this list run through that fact. Of the 105 supplement and herbal ingredients on file, 78 add sedation on top of the drowsiness levetiracetam can already cause, and seven carry a major rating, most notably alcohol (beer and wine are the best documented entries here) and kava, which can push sedation to a dangerous depth.

The rest of the picture is quieter but still matters for a seizure drug. Activated charcoal, also rated major, can pull medication out of the gut before it absorbs, and it heads a group of 17 ingredients that affect how much of an oral dose reaches the blood, so space those well apart. With 82 moderate and 16 minor entries behind the seven majors, the pattern to learn first is anything that makes you drowsy.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 82 Minor 16 No known interaction 1,347

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Levetiracetam: Top Interactions at a Glance

The most significant Levetiracetam supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 105 interacting ingredients — plus 1,347 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Levetiracetam + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Levetiracetami

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Wine + Levetiracetami

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Levetiracetami

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Levetiracetami

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Levetiracetami

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction Major Likelihood Probable Kava + Levetiracetami

Combining kava with CNS depressants can have additive sedative effects.

Read the full interaction
The complete list

Every Supplement Checked Against Levetiracetam

All 1,452 ingredients in our database, ranked by severity — 105 with a Levetiracetam interaction on file and 1,347 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Levetiracetam?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take California Poppy with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking California poppy with drugs with sedative effects may increase the risk of sedative effects.

Full California Poppy + Levetiracetam answer

Can you take Cannabichromene (cbc) with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Using cannabichromene with drugs that have sedative properties may cause additive therapeutic and adverse effects.

Full Cannabichromene (cbc) + Levetiracetam answer

Can you take Cannabidiol (cbd) with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabidiol might have additive effects if used with other CNS depressants.

Full Cannabidiol (cbd) + Levetiracetam answer

Can you take Cannabis with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might have additive effects if used with other CNS depressants.

Full Cannabis + Levetiracetam answer

Can you take Caraway with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caraway might increase the effects and adverse effects of CNS depressants.

Full Caraway + Levetiracetam answer

Can you take Catnip with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Catnip + Levetiracetam answer

Can you take Cnidium with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In laboratory research, cnidium has been shown to have sedative and hypnotic effects, possibly related to constituent coumarins.

Full Cnidium + Levetiracetam answer

Can you take Coriander with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.

Full Coriander + Levetiracetam answer

Can you take Corn Poppy with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of corn poppy with CNS depressants might increase the risk of sedation.

Full Corn Poppy + Levetiracetam answer

Can you take Corydalis Yanhusuo with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase the sedative effects of CNS depressants.

Full Corydalis Yanhusuo + Levetiracetam answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might have additive effects if used with other CNS depressants.

Full Delta-9-tetrahydrocannabinol (thc) + Levetiracetam answer

Can you take Dendrobium with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The dendrobium constituent dendrobine is reported to have convulsant effects.

Full Dendrobium + Levetiracetam answer

Can you take Elecampane with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.

Full Elecampane + Levetiracetam answer

Can you take Ephedra with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ephedra may reduce the effects of anticonvulsants.

Full Ephedra + Levetiracetam answer

Can you take European Barberry with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full European Barberry + Levetiracetam answer

Can you take Galphimia Glauca with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Galphimia glauca with CNS depressants may increase the risk of sedation.

Full Galphimia Glauca + Levetiracetam answer

Can you take Gamma Butyrolactone (gbl) with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of GBL with CNS depressants may potentiate respiratory and CNS depression.

Full Gamma Butyrolactone (gbl) + Levetiracetam answer

Can you take German Chamomile with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might have additive effects when used with CNS depressants.

Full German Chamomile + Levetiracetam answer

Can you take Ginkgo with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might reduce the effectiveness of anticonvulsants.

Full Ginkgo + Levetiracetam answer

Can you take Glutamine with Levetiracetam?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glutamine might antagonize the effects of anticonvulsant medications.

Full Glutamine + Levetiracetam answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Levetiracetam is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Levetiracetam, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Levetiracetam sits in 3 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Levetiracetam through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Levetiracetam through this category.

Anticonvulsants 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Levetiracetam through this category.

About Levetiracetam

Levetiracetam is an anticonvulsant medication used to control various types of seizures in people with epilepsy.

Generic name: Levetiracetam  ·  Brand names: Keppra, Elepsia XR, Spritam.

See the full Levetiracetam drug information

Related: does Levetiracetam deplete any nutrients?

Levetiracetam has 3 reported nutrient associations in the research literature — see the Levetiracetam nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Levetiracetam

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Levetiracetam.

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Pharmacist Counseling Corner

Levetiracetam & Supplements: Common Questions

What supplements interact with Levetiracetam?
More than you might expect — 105 in total, though they are far from equal: 7 are rated major, 82 moderate, and 16 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Levetiracetam supplement interactions are the most serious?
The 7 major-rated combinations — led by Beer, Wine, 1,4-butanediol, Activated Charcoal and Gamma-hydroxybutyrate (ghb) — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Levetiracetam?
Usually yes — most people on Levetiracetam can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Keppra have the same supplement interactions as Levetiracetam?
Yes — Keppra, Elepsia XR, Spritam all contain Levetiracetam, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Levetiracetam deplete any vitamins or nutrients?
It might — Levetiracetam has 3 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Levetiracetam nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Levetiracetam and my other medications?
This page covers Levetiracetam against supplements and herbal ingredients. Checking Levetiracetam against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Levetiracetam drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 2, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.