Drug & supplement interaction

Chelation Therapy Products + Lidocaine

Lidocaine brand names: Xylocaine, Dilocaine, Lidoject-1, Xylocaine MPF, Nervocaine, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Chelation Therapy Products and Lidocaine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Chelation Therapy Products and Lidocaine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lidocaine and Chelation Therapy Products in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chelation Therapy Products safety at a glance

Chelation Therapy... overall Use caution Real chelation is a medical treatment that needs supervision; OTC 'chelation' products are unproven and risky.
Pregnancy Possibly Unsafe When unregulated chelation therapy products are used orally or parentally or when prescription chelation therapy products are used for unproven indications and/... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When unregulated chelation therapy products are used orally or parentally or when prescription chelation therapy products are used for unproven indications and/... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lidocaine and Chelation Therapy Products? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Lidocaine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lidocaine is filed under 5 classifications — including anesthesia, cytochrome p450 2d6 (cyp2d6) substrates, topical drugs. Chelation Therapy Products has documented interactions with 3 drug classes — the most serious being insulin (major), diuretic drugs (moderate) and warfarin (coumadin) (moderate) — and none of Lidocaine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Chelation Therapy Products Does Interact With Other Medications

Chelation Therapy Products has 13 major, 77 moderate known drug interactions in our database — Lidocaine isn’t one of them. If you take anything else, check it against the full list below.

Major 13 Moderate 77 No known interaction 2,740 (incl. Lidocaine)
Taking anything else?

Check Another of Your Medications Against Chelation Therapy Products

Covers the 2,830 medications we’ve checked against Chelation Therapy Products. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Chelation Therapy Products and Lidocaine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on Additional detail

    Chelation Therapy Products

    “Intravenously, calcium disodium ethylenediamene tetraacetic acid (EDTA) can cause zinc deficiency and hypercalcemia. Disodium EDTA can occasionally reduce magnesium and potassium serum concentrations, and rarely cause insulin shock.

    Disodium EDTA, when given as a rapid infusion or highly concentrated solution, can cause hypocalcemia, leading to tetany, convulsions, cardiac arrhythmias, cardiac failure, respiratory ar…”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in arrhythmia.

    6 sources cited
    1. 5771. Lacy CF, Armstrong LL, Ingrim NB, et al. Drug Information Handbook. 6th ed. Hudson, OH:Lexi-Comp Inc 1998:439-41.
    2. 5772. Ellsworth AJ, Witt DM, Dugdale DC, et al. Medical Drug Reference. Saint Louis, MO: Mosby-Year Book Inc 1998:302-3.
    3. 5737. Grier MT, Meyers DG. So much writing, so little science: a review of 37 years literature on edetate sodium chelation therapy. Ann Pharmacother 1993;27:1504-9.
    4. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    5. 94984. Fountain JS, Reith DM. Dangers of "EDTA". N Z Med J 2014;127:126-7.
    6. 94985. Lamas GA, Goertz C, Boineau R, et al. Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. JAMA 2013;309:1241-50. PubMed

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

  • Hives Worth acting on Additional detail

    Chelation Therapy Products

    “Intravenously, disodium ethylenediamene tetraacetic acid (EDTA) can rarely cause histamine-like reactions. There are rare reports of allergic reactions to EDTA given as a nasal provocation, topically, intradermally, and subcutaneously.”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    3 sources cited
    1. 5737. Grier MT, Meyers DG. So much writing, so little science: a review of 37 years literature on edetate sodium chelation therapy. Ann Pharmacother 1993;27:1504-9.
    2. 94992. Russo PA, Banovic T, Wiese MD, et al. Systemic allergy to EDTA in local anesthetic and radiocontrast media. J Allergy Clin Immunol Pract 2014;2:225-9. PubMed
    3. 108105. Wax PM. Current use of chelation in American health care. J Med Toxicol 2013;9(4):303-7. PubMed

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

  • An allergic reaction Worth acting on Additional detail

    Chelation Therapy Products

    Recorded for Chelation Therapy Products in the same Natural Medicines adverse-effect record shown under Seizures above.

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

  • A change in taste Additional detail

    Chelation Therapy Products

    “Intravenously, ethylenediamene tetraacetic acid (EDTA) can commonly cause abdominal cramps, anorexia, nausea, vomiting, and diarrhea (15). EDTA can also sometimes cause thirst (15).

    When given orally or intravenously, 2,3-dimercaptopropane-1-sulfonate (DMPS) has caused nausea and dysgeusia.

    Orally, dimercaptosuccinic acid (DMSA) has caused gastrointestinal upset and diminished appetite.”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in anorexia.

    2 sources cited
    1. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    2. 108099. James S, Stevenson SW, Silove N, Williams K. Chelation for autism spectrum disorder (ASD). Cochrane Database Syst Rev 2015;5(5):CD010766. PubMed

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

  • Numbness or tingling / Headache reported in 4.6% of FDA reports for Lidocaine Additional detail

    Chelation Therapy Products

    “Intravenously, ethylenediamene tetraacetic acid (EDTA) can commonly cause headache and faintness (15,108103). EDTA can also sometimes cause fever, chills, fatigue, and malaise (15,108099). Disodium EDTA can occasionally cause tremors, tingling, and paresthesias (15).

    Orally, dimercaptosuccinic acid (DMSA) was associated with lethargy in one child in a clinical trial.”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in cluster headache.

    3 sources cited
    1. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    2. 108103. Villarruz MV, Dans A, Tan F. Chelation therapy for atherosclerotic cardiovascular disease. Cochrane Database Syst Rev 2002;(4):CD002785. PubMed
    3. 108099. James S, Stevenson SW, Silove N, Williams K. Chelation for autism spectrum disorder (ASD). Cochrane Database Syst Rev 2015;5(5):CD010766. PubMed

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Low blood pressure Additional detail

    Chelation Therapy Products

    “Intravenously, chelation therapy products such as 2,3-dimercaptopropane-1-sulfonate (DMPS) or ethylenediamene tetraacetic acid (EDTA) have been associated with hypotension and irregular heartbeat. Intravenously, EDTA can also cause thrombophlebitis.”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in arrhythmia.

    6 sources cited
    1. 5737. Grier MT, Meyers DG. So much writing, so little science: a review of 37 years literature on edetate sodium chelation therapy. Ann Pharmacother 1993;27:1504-9.
    2. 5771. Lacy CF, Armstrong LL, Ingrim NB, et al. Drug Information Handbook. 6th ed. Hudson, OH:Lexi-Comp Inc 1998:439-41.
    3. 5772. Ellsworth AJ, Witt DM, Dugdale DC, et al. Medical Drug Reference. Saint Louis, MO: Mosby-Year Book Inc 1998:302-3.
    4. 108105. Wax PM. Current use of chelation in American health care. J Med Toxicol 2013;9(4):303-7. PubMed
    5. 108106. American College of Medical Toxicology and The American Academy of Clinical Toxicology. https://www.choosingwisely.org/clinician-lists/american-college-academy-medical-toxicology-chelation/. Accessed May 18, 2022.
    6. 108099. James S, Stevenson SW, Silove N, Williams K. Chelation for autism spectrum disorder (ASD). Cochrane Database Syst Rev 2015;5(5):CD010766. PubMed

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

  • Tiredness reported in 5.1% of FDA reports for Lidocaine Additional detail

    Chelation Therapy Products

    Recorded for Chelation Therapy Products in the same Natural Medicines adverse-effect record shown under Numbness or tingling / Headache above.

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Itching / Swelling Additional detail

    Chelation Therapy Products

    Recorded for Chelation Therapy Products in the same Natural Medicines adverse-effect record shown under Hives above.

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

Showing the 10 most notable of 13 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Chelation Therapy Products but not commonly for Lidocaine: a severe skin reaction, stomach upset, a heart attack and an irregular heartbeat.

Effects for Lidocaine come from the ADVERSE REACTIONS section of its FDA label; effects for Chelation Therapy Products come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 96,036 voluntary FDA FAERS reports for Lidocaine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Chelation Therapy Products in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When unregulated chelation therapy products are used orally or parentally or when prescription chelation therapy products are used for unproven indications and/or in unapproved doses or routes of administration. The American College of Medical Toxicology and The American Academy of Clinical Toxicology recommend against the unapproved use of chelation therapy products. Chelation therapy products can have teratogenic effects and result in severe side effects including dehydration, hypocalcemia, kidney failure, neurodevelopmental toxicity, and death.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Lidocaine

This page covers Chelation Therapy Products only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lidocaine page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Fever Bark (major), Grapefruit (major), St. John's Wort (major), 1,3-dmaa (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 111 moderate · 31 minor.

From our pharmacist’s overview on the Lidocaine page

“Lidocaine (Xylocaine) deserves genuine care on this page, and I would learn its three major-rated entries first. Grapefruit and St.”

Reviewed by 2 · Jul 18, 2026

Open the Lidocaine interaction page

How much people look this up

Where Chelation Therapy Products and Lidocaine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chelation Therapy Products
Steady interest

#799 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lidocaine
Top 10%

#229 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chelation Therapy Products reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chelation Therapy Products and Lidocaine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chelation Therapy Products

What is Chelation Therapy Products?

  • Heavy metal poisoning (lead, mercury, arsenic, iron)
  • Marketed for heart and artery health
  • Promoted for 'detoxification'
  • Promoted for circulation problems
  • Sometimes promoted for autism (not supported)

Chelation therapy uses binding agents (like EDTA, DMSA, or DMPS) that latch onto certain metals so the body can remove them. It is an FDA-approved, doctor-supervised treatment only for proven heavy metal poisoning; over-the-counter 'chelation' supplements and unsupervised IV chelation for heart disease or detox are not proven safe or effective and can be dangerous. Talk to your doctor or pharmacist before considering any chelation product.

Not applicable (synthetic and oral binding agents) · Intravenous (IV) infusions, oral capsules, suppositories, and sprays

An interaction check asks whether these two react with each other — it does not ask whether Chelation Therapy Products is a good idea for someone in your situation. Here is what our Chelation Therapy Products record says about it on its own.

Chelation Therapy Products: dosing

There is no safe "do-it-yourself" chelation dose. When chelation is medically needed for poisoning, the agent, dose, and schedule are chosen by a doctor based on the specific metal, blood levels, body weight, and kidney function, with close monitoring.Over-the-counter "chelation" supplements are not standardized, and their actual contents and strength are uncertain. We do not recommend self-dosing these products.If a product label gives directions, do not assume they are safe or effective.

From our Chelation Therapy Products monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chelation Therapy Products monograph & all interactions
Medication

About Lidocaine Transdermal Patch

What Is Lidocaine Transdermal Patch Used For?

Brand names: Xylocaine, Dilocaine, Lidoject-1, Xylocaine MPF, Nervocaine, Lidoject-2, Duo-Trach Kit, Octocaine, Lidoderm, Ztlido

Lidocaine skin patches are applied directly to the painful area to treat post-herpetic neuralgia (PHN) — the persistent burning or aching nerve pain that can remain after a shingles outbreak.

Lidoderm (lidocaine patch 5%) and ZTlido (lidocaine topical system 1.8%) are both indicated for this use in adults. Note that despite their different strengths, one ZTlido topical system provides equivalent lidocaine exposure to one Lidoderm patch.

Most-Reported Side Effects for Lidocaine

From FAERS, the FDA’s public side-effect reporting system (96,036 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 4,961 reports
Fatigue 4,867 reports
Headache 4,439 reports
Product quality issue 3,920 reports
Dyspnea 3,658 reports
See full Lidocaine Transdermal Patch drug information
Keep checking

Other Drugs & Chelation Therapy Products

Browse every other medication we’ve checked against Chelation Therapy Products — both the ones with a known interaction and the ones without. Select any drug for the full detail.

13Major
77Moderate
0Minor
2,739No known interaction
13 Major 77 Moderate 2,739 No interaction
Major

13 interactions

Moderate

77 interactions

Showing 60 of 77 moderate interactions — see all 77 on the Chelation Therapy Products page.

No interaction 2,739 drugs checked — show the list

We also checked Chelation Therapy Products against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,739 medications checked with no known interaction — see the full Chelation Therapy Products list.

See the full Chelation Therapy Products interactions page
See every supplement checked against Lidocaine, ranked by severity
Evidence & sources

Chelation Therapy Products References

The 21 references that drive our Chelation Therapy Products monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Grebe HB, Gregory PJ. Inhibition of warfarin anticoagulation associated with chelation therapy. Pharmacotherapy 2002;22:1067-9.. PubMed
  3. Grier MT, Meyers DG. So much writing, so little science: a review of 37 years literature on edetate sodium chelation therapy. Ann Pharmacother 1993;27:1504-9.
  4. Christensen K, Theilade D. Edta chelation therapy: an ethical problem. Med Hypotheses 1999;53:69-70. PubMed
  5. Lacy CF, Armstrong LL, Ingrim NB, et al. Drug Information Handbook. 6th ed. Hudson, OH:Lexi-Comp Inc 1998:439-41.
  6. Ellsworth AJ, Witt DM, Dugdale DC, et al. Medical Drug Reference. Saint Louis, MO: Mosby-Year Book Inc 1998:302-3.
  7. Fountain JS, Reith DM. Dangers of "EDTA". N Z Med J 2014;127:126-7.
  8. Lamas GA, Goertz C, Boineau R, et al. Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. JAMA 2013;309:1241-50. PubMed
  9. Russo PA, Banovic T, Wiese MD, et al. Systemic allergy to EDTA in local anesthetic and radiocontrast media. J Allergy Clin Immunol Pract 2014;2:225-9. PubMed
  10. Centers for Disease Control and Prevention (CDC). Deaths associated with hypocalcemia from chelation therapy--Texas, Pennsylvania, and Oregon, 2003-2005. MMWR Morb Mortal Wkly Rep 2006;55(8):204-7.
  11. Brown MJ, Willis T, Omalu B, Leiker R. Deaths resulting from hypocalcemia after administration of edetate disodium: 2003-2005. Pediatrics 2006;118(2):e534-6. PubMed
  12. Baxter AJ, Krenzelok EP. Pediatric fatality secondary to EDTA chelation. Clin Toxicol (Phila) 2008;46(10):1083-4. PubMed
  13. Atwood KC, Woeckner E. In pediatric fatality, edetate disodium was no accident. Clin Toxicol (Phila) 2009;47(3):256. PubMed
  14. James S, Stevenson SW, Silove N, Williams K. Chelation for autism spectrum disorder (ASD). Cochrane Database Syst Rev 2015;5(5):CD010766. PubMed
  15. Lamas GA, Hussein SJ. EDTA chelation therapy meets evidence-based medicine. Complement Ther Clin Pract 2006;12(3):213-5. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chelation Therapy Products and Lidocaine Together: Common Questions

Is it safe to take Chelation Therapy Products with Lidocaine?
We do not list a known interaction between Chelation Therapy Products and Lidocaine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Chelation Therapy Products and Lidocaine have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Chelation Therapy Products and Lidocaine combination checked?
Interactions in our licensed database are recorded against drug classes. Lidocaine is filed under 5 classifications, and Chelation Therapy Products has documented interactions with 3 drug classes — none of Lidocaine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Chelation Therapy Products interact with any other medications?
Yes. Chelation Therapy Products has 90 documented drug interactions in our database — Lidocaine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Lidocaine interact with any supplements?
Yes. Lidocaine has documented interactions with 145 supplements in our database — Chelation Therapy Products is not one of them. The Lidocaine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chelation Therapy Products monograph Uses, safety profile, and every drug interaction in one place Lidocaine Transdermal Patch drug information The full plain-English guide to this medication Lidocaine supplement interactions Every supplement checked against Lidocaine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 21 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lidocaine and Chelation Therapy Products?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.