Drug & supplement interaction

Coltsfoot + Aspirin, Omeprazole

Aspirin, Omeprazole brand name: Yosprala.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Coltsfoot has a moderate interaction with Aspirin, Omeprazole. Concomitant use might increase the risk of bleeding due to decreased platelet aggregation.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Coltsfoot and Aspirin, Omeprazole

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Aspirin, Omeprazole

Aspirin, Omeprazole falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Coltsfoot interacts with.

Concomitant use might increase the risk of bleeding due to decreased platelet aggregation. Coltsfoot has been reported to inhibit platelet aggregation; avoid concomitant use. Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Your Yosprala combines two medicines, but the part that matters here is the aspirin. Aspirin works by making your platelets less sticky so they don't clump into clots, which is exactly how it protects against heart attack and stroke. The catch is that this also means you bruise and bleed a bit more easily.

Coltsfoot has been reported to do something similar, gently lowering platelet stickiness on its own. Stack the two together and, in theory, you could nudge your bleeding risk a little higher, things like easier bruising, nosebleeds, or a small cut that takes longer to stop. I'll be honest: this is a theoretical concern based on how the herb behaves in lab settings, not proven in people. Still, coltsfoot also carries liver-safety worries of its own, so please run it past your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Hwang SB, Chang MN, Garcia ML, et al. L-652,469--a dual receptor antagonist of platelet activating factor and dihydropyridines from Tussilago farfara L. Eur J Pharmacol 1987;141:269-81. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Coltsfoot Also Interacts With Other Medications

Coltsfoot has 373 moderate known drug interactions in our database — the Aspirin, Omeprazole one above is one of them. If you take anything else, check it against the full list below.

Moderate 373 No known interaction 2,457 (incl. Aspirin, Omeprazole)
Taking anything else?

Check Another of Your Medications Against Coltsfoot

Covers the 2,830 medications we’ve checked against Coltsfoot. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aspirin, Omeprazole

This page covers Coltsfoot only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Omeprazole page lists 318 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Grapefruit (major).

By severity: 9 major · 256 moderate · 53 minor.

From our pharmacist’s overview on the Aspirin, Omeprazole page

“Yosprala pairs aspirin, a blood thinner, with omeprazole, an acid reducer whose job is to shield the stomach from that aspirin, so this list carries real weight and warrants genuine care. Of the 318 supplements and herbs on file, nine are rated major, and understanding those first matters more than reading the rest.”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Omeprazole interaction page

One more smart check

Taking Coltsfoot as Part of a Dietary Supplement Product? Check It for Interactions

We hold 60 real supplement products containing Coltsfoot, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coltsfoot. Your product may carry other ingredients that interact with Aspirin, Omeprazole too, on top of Coltsfoot — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coltsfoot and Aspirin, Omeprazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coltsfoot
Steady interest

#1,104 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Omeprazole
Top 25%

#495 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Coltsfoot

What is Coltsfoot?

Coltsfoot
  • Cough
  • Sore throat
  • Bronchitis and congestion
  • Loosening mucus (expectorant)
  • Asthma symptoms

Coltsfoot is a traditional herb long used to soothe coughs and clear mucus, but solid human evidence for these uses is lacking. More importantly, the raw plant can contain liver-toxic pyrrolizidine alkaloids, so it carries real safety concerns and is best avoided unless you use a product certified to be free of these compounds.

Read the full Coltsfoot monograph & all interactions
Keep checking

Other Drugs & Coltsfoot

Browse every other medication we’ve checked against Coltsfoot — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
373Moderate
0Minor
2,456No known interaction
373 Moderate 2,456 No interaction
Moderate

373 interactions

Showing 60 of 373 moderate interactions — see all 373 on the Coltsfoot page.

No interaction 2,456 drugs checked — show the list

We also checked Coltsfoot against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,456 medications checked with no known interaction — see the full Coltsfoot list.

See the full Coltsfoot interactions page
See every supplement checked against Aspirin, Omeprazole, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Coltsfoot monograph › Uses, safety, and every drug interaction in one place Aspirin, Omeprazole supplement interactions › Every supplement checked against Aspirin, Omeprazole, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Coltsfoot and Aspirin, Omeprazole Together: Common Questions

Can you take Coltsfoot with Aspirin, Omeprazole?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Coltsfoot and Aspirin, Omeprazole interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Aspirin, Omeprazole and Coltsfoot?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.