Drug & supplement interaction

Coltsfoot + Ondansetron

Ondansetron brand name: Zofran.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Coltsfoot and Ondansetron in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Coltsfoot and Ondansetron

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ondansetron and Coltsfoot in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Coltsfoot safety at a glance

Coltsfoot overall Use caution May contain liver-toxic pyrrolizidine alkaloids; use only certified PA-free products, if at all.
Pregnancy Likely Unsafe When products containing hepatotoxic pyrrolizidine alkaloid (PA) constituents are used orally. Coltsfoot preparations containing hepatotoxic pyrrolizidine alkal... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in coltsfoot are excreted in milk. There is insufficient reliable information available a... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ondansetron and Coltsfoot? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ondansetron

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ondansetron is filed under 7 classifications — including serotonergic drugs, serotonergic drugs, cytochrome p450 1a2 (cyp1a2) substrates. Coltsfoot has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antihypertensive drugs (moderate) and cytochrome p450 3a4 (cyp3a4) inducers (moderate) — and none of Ondansetron’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Coltsfoot Does Interact With Other Medications

Coltsfoot has 374 moderate known drug interactions in our database — Ondansetron isn’t one of them. If you take anything else, check it against the full list below.

Moderate 374 No known interaction 2,456 (incl. Ondansetron)
Taking anything else?

Check Another of Your Medications Against Coltsfoot

Covers the 2,830 medications we’ve checked against Coltsfoot. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Coltsfoot and Ondansetron May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    Coltsfoot

    “Orally, coltsfoot might cause lung damage. The major concern with coltsfoot use is its pyrrolizidine alkaloid (PA) content. These constituents can cause lung damage with pulmonary-arterial hypertension.”

    Coltsfoot · Natural Medicines adverse-effect record, reported in hypertension.

    2 sources cited
    1. 12841. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
    2. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.

    Ondansetron

    Listed in the ADVERSE REACTIONS section of the FDA label for Ondansetron. Read the label on DailyMed ›

Reported for Coltsfoot but not commonly for Ondansetron: blood clots, liver problems, vomiting and diarrhea.

Effects for Ondansetron come from the ADVERSE REACTIONS section of its FDA label; effects for Coltsfoot come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 121,840 voluntary FDA FAERS reports for Ondansetron that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Coltsfoot in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When products containing hepatotoxic pyrrolizidine alkaloid (PA) constituents are used orally. Coltsfoot preparations containing hepatotoxic pyrrolizidine alkaloid (PA) constituents might be teratogenic and hepatotoxic. There is one case report of fatal hepatic veno-occlusive disease in a neonate associated with regular maternal consumption during pregnancy of an herb tea containing several pyrrolizidine alkaloid herbs, including coltsfoot. There is insufficient reliable information available about the safety of using coltsfoot products certified and labeled as hepatotoxic PA-free during pregnancy; avoid using.

Lactation Likely Unsafe

When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in coltsfoot are excreted in milk. There is insufficient reliable information available about the safety of using coltsfoot products certified and labeled as hepatotoxic PA-free during lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Coltsfoot or Ondansetron

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Coltsfoot or Ondansetron, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ondansetron

This page covers Coltsfoot only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ondansetron page lists 195 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).

By severity: 4 major · 145 moderate · 46 minor.

From our pharmacist’s overview on the Ondansetron page

“Ondansetron (Zofran) often stands between you and relentless nausea from chemotherapy or surgery, so read this page carefully. Four of the 195 ingredients rate major.”

Reviewed by 2 · Jul 18, 2026

Open the Ondansetron interaction page

One more smart check

Taking Coltsfoot as Part of a Dietary Supplement Product? Check It for Interactions

We hold 60 real supplement products containing Coltsfoot, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coltsfoot. Even though Coltsfoot itself has no known interaction with Ondansetron, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coltsfoot and Ondansetron Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coltsfoot
Top half

#485 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ondansetron
Top half

#1,255 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Coltsfoot reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Coltsfoot and Ondansetron records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Coltsfoot

What is Coltsfoot?

Coltsfoot
  • Cough
  • Sore throat
  • Bronchitis and congestion
  • Loosening mucus (expectorant)
  • Asthma symptoms

Coltsfoot is a traditional herb long used to soothe coughs and clear mucus, but solid human evidence for these uses is lacking. More importantly, the raw plant can contain liver-toxic pyrrolizidine alkaloids, so it carries real safety concerns and is best avoided unless you use a product certified to be free of these compounds.

Tussilago farfara · Asteraceae · Leaves and flowers · Tea, dried herb, tincture, syrup, capsules, lozenges

An interaction check asks whether these two react with each other — it does not ask whether Coltsfoot is a good idea for someone in your situation. Here is what our Coltsfoot record says about it on its own.

Coltsfoot: dosing

There is no established, standardized dose for coltsfoot, and because of the safety concerns, no dose can be considered clearly safe. Traditional products include teas, syrups, and tinctures, but the amount of active and toxic compounds can vary widely between products.If you choose to use coltsfoot despite the risks, only use a product certified to be free of pyrrolizidine alkaloids, follow the label directions exactly, and use it for the shortest time possible.

From our Coltsfoot monograph — the full record covers uses, side effects and every documented interaction.

Read the full Coltsfoot monograph & all interactions
Medication

About Ondansetron

What Is Ondansetron Used For?

Brand name: Zofran

Ondansetron is used to prevent nausea and vomiting in several situations. Oral forms (tablets, orally disintegrating tablets, and oral solution) are approved to prevent nausea and vomiting from highly or moderately emetogenic (nausea-causing) cancer chemotherapy, from radiation therapy to the abdomen or whole body, and from surgery.

Ondansetron injection (given intravenously or intramuscularly in a clinical setting) is approved to prevent nausea and vomiting from emetogenic cancer chemotherapy — including high-dose cisplatin — in adults and children as young as 6 months old, as well as to prevent postoperative nausea and vomiting.

Most-Reported Side Effects for Ondansetron

From FAERS, the FDA’s public side-effect reporting system (121,840 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 14,459 reports
Fatigue 10,275 reports
Diarrhea 9,488 reports
Vomiting 8,777 reports
Dyspnea 5,971 reports
See full Ondansetron drug information
Keep checking

Other Drugs & Coltsfoot

Browse every other medication we’ve checked against Coltsfoot — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
374Moderate
0Minor
2,455No known interaction
374 Moderate 2,455 No interaction
Moderate

374 interactions

Showing 60 of 374 moderate interactions — see all 374 on the Coltsfoot page.

No interaction 2,455 drugs checked — show the list

We also checked Coltsfoot against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,455 medications checked with no known interaction — see the full Coltsfoot list.

See the full Coltsfoot interactions page
See every supplement checked against Ondansetron, ranked by severity
Evidence & sources

Coltsfoot References

The 8 references that drive our Coltsfoot monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Roulet M, Laurini R, Rivier L, Calame A. Hepatic veno-occlusive disease in newborn infant of a woman drinking herbal tea. J Pediatr 1988;112:433-6. PubMed
  2. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  3. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  4. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  5. Wilson BE, Hobbs WN. Case report: pseudoephedrine-associated thyroid storm: thyroid hormone-catecholamine interactions. Am J Med Sci 1993;306:317-9. PubMed
  6. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  7. Hwang SB, Chang MN, Garcia ML, et al. L-652,469--a dual receptor antagonist of platelet activating factor and dihydropyridines from Tussilago farfara L. Eur J Pharmacol 1987;141:269-81. PubMed
  8. Freshour JE, Odle B, Rikhye S, Stewart DW. Coltsfoot as a potential cause of deep vein thrombosis and pulmonary embolism in a patient also consuming kava and blue vervain. J Diet Suppl 2012;9:149-54. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Coltsfoot and Ondansetron Together: Common Questions

Is it safe to take Coltsfoot with Ondansetron?
We do not list a known interaction between Coltsfoot and Ondansetron. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Coltsfoot and Ondansetron have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Coltsfoot and Ondansetron combination checked?
Interactions in our licensed database are recorded against drug classes. Ondansetron is filed under 7 classifications, and Coltsfoot has documented interactions with 3 drug classes — none of Ondansetron's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Coltsfoot interact with any other medications?
Yes. Coltsfoot has 374 documented drug interactions in our database — Ondansetron is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ondansetron interact with any supplements?
Yes. Ondansetron has documented interactions with 195 supplements in our database — Coltsfoot is not one of them. The Ondansetron interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Coltsfoot monograph Uses, safety profile, and every drug interaction in one place Ondansetron drug information The full plain-English guide to this medication Ondansetron supplement interactions Every supplement checked against Ondansetron, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ondansetron and Coltsfoot?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.