Drug & supplement interaction

Coriander + Buspirone

Buspirone brand name: BuSpar.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Coriander and Buspirone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Coriander and Buspirone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Buspirone and Coriander in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Coriander safety at a glance

Coriander overall Generally safe Coriander is generally safe in normal food amounts for most people.
Pregnancy Use caution Food amounts are likely fine, but concentrated medicinal doses or essential oil should be avoided without medical advice.
Breastfeeding Use caution Food amounts are likely fine, but medicinal doses lack safety data, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Buspirone and Coriander? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Buspirone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Buspirone is filed under 5 classifications — including serotonergic drugs, serotonergic drugs, cytochrome p450 3a4 (cyp3a4) substrates. Coriander has documented interactions with 4 drug classes — the most serious being antidiabetes drugs (moderate), antihypertensive drugs (moderate) and cns depressants (moderate) — and none of Buspirone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Coriander Does Interact With Other Medications

Coriander has 717 moderate known drug interactions in our database — Buspirone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 717 No known interaction 2,113 (incl. Buspirone)
Taking anything else?

Check Another of Your Medications Against Coriander

Covers the 2,830 medications we’ve checked against Coriander. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Coriander and Buspirone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • A severe allergic reaction Worth acting on Additional detail

    Coriander

    “A case of anaphylactic reaction characterized by generalized urticaria, conjunctivitis, oropharyngeal angioedema, and bronchospasms has been reported in a 25-year-old spice worker who consumed food containing coriander fruit. The digestive spice allergy was attributed to sensitization to coriander caused by occupational exposure to coriander fruit, powder, and dust.”

    Coriander · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    5 sources cited
    1. 46192. Ebo, D. G., Bridts, C. H., Mertens, M. H., and Stevens, W. J. Coriander anaphylaxis in a spice grinder with undetected occupational allergy. Acta Clin Belg. 2006;61(3):152-156. PubMed
    2. 46226. van Toorenenbergen, A. W. and Dieges, P. H. Immunoglobulin E antibodies against coriander and other spices. J Allergy Clin Immunol. 1985;76(3):477-481. PubMed
    3. 46245. Sastre, J., Olmo, M., Novalvos, A., Ibanez, D., and Lahoz, C. Occupational asthma due to different spices. Allergy 1996;51(2):117-120. PubMed
    4. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
    5. 46168. Kanerva, L. and Soini, M. Occupational protein contact dermatitis from coriander. Contact Dermatitis 2001;45(6):354-355. PubMed

    Buspirone

    Listed in the ADVERSE REACTIONS section of the FDA label for Buspirone. Read the label on DailyMed ›

  • Hives Worth acting on Additional detail

    Coriander

    Recorded for Coriander in the same Natural Medicines adverse-effect record shown under A severe allergic reaction above.

    Buspirone

    Listed in the ADVERSE REACTIONS section of the FDA label for Buspirone. Read the label on DailyMed ›

  • A stuffy or runny nose Additional detail

    Coriander

    Recorded for Coriander in the same Natural Medicines adverse-effect record shown under A severe allergic reaction above.

    Buspirone

    Listed in the ADVERSE REACTIONS section of the FDA label for Buspirone. Read the label on DailyMed ›

  • Itching Additional detail

    Coriander

    “Topically, coriander can cause pruritus and a burning sensation.”

    Coriander · Natural Medicines adverse-effect record, reported in pruritus.

    1 source cited
    1. 97874. Beikert FC, Anastasiadou Z, Fritzen B, Frank U, Augustin M. Topical treatment of tinea pedis using 6% coriander oil in unguentum leniens: a randomized, controlled, comparative pilot study. Dermatology. 2013;226(1):47-51. PubMed

    Buspirone

    Listed in the ADVERSE REACTIONS section of the FDA label for Buspirone. Read the label on DailyMed ›

  • A skin rash Additional detail

    Coriander

    Recorded for Coriander in the same Natural Medicines adverse-effect record shown under A severe allergic reaction above.

    Buspirone

    Listed in the ADVERSE REACTIONS section of the FDA label for Buspirone. Read the label on DailyMed ›

Reported for Coriander but not commonly for Buspirone: wheezing.

Effects for Buspirone come from the ADVERSE REACTIONS section of its FDA label; effects for Coriander come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Buspirone Is Prescribed For, and What Coriander Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Buspirone is a prescription medicine with approved uses on its FDA label. Coriander is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Buspirone is prescribed for: Buspirone tablets and capsules are used to manage anxiety disorders or to relieve anxiety symptoms in the short term. Its effectiveness has been shown in clinical trials focused on Generalized Anxiety Disorder (GAD) — a condition marked by persistent, hard-to-control worry along with physical symptoms like muscle tension, restlessness, difficulty concentrating, and sleep problems. Buspirone has also been shown to relieve anxiety in people who have mild depressive symptoms alongside their anxiety. Everyday stress and tension, on their own, generally do not require treatment with a medicine like buspirone.

Coriander has been studied for:

  • Anxiety studied, not established Coriander has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Coriander for anxiety

    Although there has been interest in using oral coriander for anxiety, there is insufficient reliable information about the clinical effects of coriander for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Buspirone on your own; if you are taking Coriander for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Coriander or Buspirone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Coriander or Buspirone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Buspirone

This page covers Coriander only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Buspirone page lists 155 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 5-htp (moderate).

By severity: 4 major · 108 moderate · 43 minor.

From our pharmacist’s overview on the Buspirone page

“I counsel genuine caution when supplements meet buspirone (BuSpar), the anxiety medication, because four of its 155 documented interactions are rated major. The bulk of the list, 121 ingredients, changes how your liver clears buspirone through the CYP3A4 enzyme, pushing its level up toward dizziness and drowsiness or down until the anx…”

Reviewed by 2 · Jul 18, 2026

Open the Buspirone interaction page

One more smart check

Taking Coriander as Part of a Dietary Supplement Product? Check It for Interactions

We hold 934 real supplement products containing Coriander, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coriander. Even though Coriander itself has no known interaction with Buspirone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coriander and Buspirone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coriander
Top 25%

#293 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Buspirone
Top 5%

#54 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Coriander reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Coriander and Buspirone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Coriander

What is Coriander?

Coriander
  • Digestive upset and gas
  • Appetite stimulation
  • Mild antimicrobial (topical)
  • Diarrhea and IBS symptoms
  • General flavoring and traditional remedy

Coriander (also called cilantro) is a common cooking herb and spice that has long been used in traditional medicine for digestive complaints. As a food it is generally safe for most people, but high-quality human studies supporting its medicinal benefits are limited. Talk with your pharmacist or doctor before using concentrated extracts or essential oils.

Coriandrum sativum · Apiaceae · Seeds (fruit), leaves, and essential oil · Culinary spice and herb, tea, capsules, tincture/extract, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Coriander is a good idea for someone in your situation. Here is what our Coriander record says about it on its own.

Coriander: dosing

There is no standardized or proven medicinal dose of coriander. Amounts used in studies and traditional remedies vary widely depending on the form (tea, seeds, capsule, or oil).If you choose to use a coriander supplement, follow the directions on the product label and do not exceed the recommended amount. Essential oils are very concentrated and should not be taken by mouth without professional guidance.

From our Coriander monograph — the full record covers uses, side effects and every documented interaction.

Read the full Coriander monograph & all interactions
Medication

About Buspirone

What Is Buspirone Used For?

Brand name: BuSpar

Buspirone tablets and capsules are used to manage anxiety disorders or to relieve anxiety symptoms in the short term. Its effectiveness has been shown in clinical trials focused on Generalized Anxiety Disorder (GAD) — a condition marked by persistent, hard-to-control worry along with physical symptoms like muscle tension, restlessness, difficulty concentrating, and sleep problems.

Buspirone has also been shown to relieve anxiety in people who have mild depressive symptoms alongside their anxiety. Everyday stress and tension, on their own, generally do not require treatment with a medicine like buspirone.

See full Buspirone drug information
Keep checking

Other Drugs & Coriander

Browse every other medication we’ve checked against Coriander — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
717Moderate
0Minor
2,112No known interaction
717 Moderate 2,112 No interaction
Moderate

717 interactions

Showing 60 of 717 moderate interactions — see all 717 on the Coriander page.

No interaction 2,112 drugs checked — show the list

We also checked Coriander against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,112 medications checked with no known interaction — see the full Coriander list.

See the full Coriander interactions page
See every supplement checked against Buspirone, ranked by severity
Evidence & sources

Coriander References

The 12 references that drive our Coriander monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 1990;33:462-4. PubMed
  3. Gray, A. M. and Flatt, P. R. Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander). Br.J Nutr. 1999;81(3):203-209.
  4. Kanerva, L. and Soini, M. Occupational protein contact dermatitis from coriander. Contact Dermatitis 2001;45(6):354-355. PubMed
  5. Emamghoreishi, M., Khasaki, M., and Aazam, M. F. Coriandrum sativum: evaluation of its anxiolytic effect in the elevated plus-maze. J Ethnopharmacol. 1-15-2005;96(3):365-370. PubMed
  6. Ebo, D. G., Bridts, C. H., Mertens, M. H., and Stevens, W. J. Coriander anaphylaxis in a spice grinder with undetected occupational allergy. Acta Clin Belg. 2006;61(3):152-156. PubMed
  7. Eidi, M., Eidi, A., Saeidi, A., Molanaei, S., Sadeghipour, A., Bahar, M., and Bahar, K. Effect of coriander seed (Coriandrum sativum L.) ethanol extract on insulin release from pancreatic beta cells in streptozotocin-induced diabetic rats. Phytother.Res
  8. Jabeen, Q., Bashir, S., Lyoussi, B., and Gilani, A. H. Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities. J Ethnopharmacol. 2-25-2009;122(1):123-130. PubMed
  9. van Toorenenbergen, A. W. and Dieges, P. H. Immunoglobulin E antibodies against coriander and other spices. J Allergy Clin Immunol. 1985;76(3):477-481. PubMed
  10. Ashwood-Smith, M. J., Warrington, P. J., Jenkins, M., Ceska, O., and Romaniuk, P. J. Photobiological properties of a novel, naturally occurring furoisocoumarin, coriandrin. Photochem.Photobiol. 1989;50(6):745-751. PubMed
  11. Sastre, J., Olmo, M., Novalvos, A., Ibanez, D., and Lahoz, C. Occupational asthma due to different spices. Allergy 1996;51(2):117-120. PubMed
  12. Beikert FC, Anastasiadou Z, Fritzen B, Frank U, Augustin M. Topical treatment of tinea pedis using 6% coriander oil in unguentum leniens: a randomized, controlled, comparative pilot study. Dermatology. 2013;226(1):47-51. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Coriander and Buspirone Together: Common Questions

Is it safe to take Coriander with Buspirone?
We do not list a known interaction between Coriander and Buspirone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Coriander and Buspirone have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Coriander and Buspirone used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Coriander in each. That is a conversation for your prescriber, especially if Buspirone is being adjusted to a target.
How was the Coriander and Buspirone combination checked?
Interactions in our licensed database are recorded against drug classes. Buspirone is filed under 5 classifications, and Coriander has documented interactions with 4 drug classes — none of Buspirone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Coriander interact with any other medications?
Yes. Coriander has 717 documented drug interactions in our database — Buspirone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Buspirone interact with any supplements?
Yes. Buspirone has documented interactions with 155 supplements in our database — Coriander is not one of them. The Buspirone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Coriander monograph Uses, safety profile, and every drug interaction in one place Buspirone drug information The full plain-English guide to this medication Buspirone supplement interactions Every supplement checked against Buspirone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 12 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Buspirone and Coriander?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.