Drug & supplement interaction

Delta-8-tetrahydrocannabinol (delta-8-thc) + Insulin Lispro

Insulin Lispro brand names: Admelog, Admelog Solostar.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Delta-8-tetrahydrocannabinol (delta-8-thc) and Insulin Lispro in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Insulin Lispro states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Delta-8-tetrahydrocannabinol (delta-8-thc) and Insulin Lispro

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Insulin Lispro and Delta-8-tetrahydrocannabinol (delta-8-thc) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Delta-8-tetrahydrocannabinol (delta-8-thc) at all — not against Insulin Lispro, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Delta-8-tetrahydrocannabinol (delta-8-thc) safety at a glance

Delta-8-tetrahydro... overall Use caution It is psychoactive, largely unregulated, and may contain harmful impurities from chemical processing.
Pregnancy Avoid THC compounds can cross the placenta and may harm fetal development; avoid use.
Breastfeeding Avoid THC passes into breast milk and may affect the infant; avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Insulin Lispro and Delta-8-tetrahydrocannabinol (delta-8-thc)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Delta-8-tetrahydrocannabinol (delta-8-thc) and Insulin Lispro May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Shortness of breath Worth acting on Additional detail

    Delta-8-tetrahydrocannabinol (delta-8-thc)

    “A large case series reports pulmonary disorders (e.g., cough, dry throat, dyspnea, painful respiration) as some of the most frequently noted adverse effects with delta-8-THC after assessing a public forum of 98,700 subscribers. Of 183 adverse events related to delta-8-THC reported to the US Food and Drug Administration, 33 report dyspnea, 17 report respiratory disorder, and 15 report cough.”

    Delta-8-tetrahydrocannabinol (delta-8-thc) · Natural Medicines adverse-effect record, reported in cough.

    3 sources cited
    1. 113017. Leas EC, Harati RM, Satybaldiyeva N, et al. Self-reported adverse events associated with ?(8)-Tetrahydrocannabinol (Delta-8-THC) Use. J Cannabis Res 2023;5(1):15. PubMed
    2. 113026. Simon TA, Simon JH, Heaning EG, Gomez-Caminero A, Marcu JP. Delta-8, a Cannabis-Derived Tetrahydrocannabinol Isomer: Evaluating Case Report Data in the Food and Drug Administration Adverse Event Reporting System (FAERS) Database. Drug Healthc Patient Saf PubMed
    3. 113033. Bradley EK, Hoots BE, Bradley ES, Roehler DR. Unintentional ingestion of putative delta-8 tetrahydrocannabinol by two youth requiring critical care: a case report. J Cannabis Res 2023;5(1):9. PubMed

    “Based on statistics from the American Association of Poison Control Centers, hospitalization occurred in 18% of 661 reported exposures to delta-8-THC in the first 7 months of 2021. In the 8-month period ending in July 2021, 14 of 22 cases reported to the US FDA presented to the hospital for adverse effects related to delta-8-THC-containing products.”

    Delta-8-tetrahydrocannabinol (delta-8-thc) · Natural Medicines adverse-effect record, reported in hypotension.

    3 sources cited
    1. 106108. Centers for Disease Control and Prevention (CDC). Increases in availability of cannabis products containing delta-8 THC and reported cases of adverse events. September 2021. https://emergency.cdc.gov/han/2021/han00451.asp. Accessed October 2, 2021.
    2. 106107. US Food and Drug Administration (FDA). 5 things to know about delta-8 tetrahydrocannabinol - delta-8 THC. September 2021. https://www.fda.gov/consumers/consumer-updates/5-things-know-about-delta-8-tetrahydrocannabinol-delta-8-thc. Accessed October 2, 2021
    3. 107322. Akpunonu P, Baum RA, Reckers A, et al. Sedation and Acute Encephalopathy in a Pediatric Patient Following Ingestion of Delta-8-Tetrahydrocannabinol Gummies. Am J Case Rep 2021;22:e933488. PubMed

    Insulin Lispro

    Listed in the ADVERSE REACTIONS section of the FDA label for Insulin Lispro. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Delta-8-tetrahydrocannabinol (delta-8-thc)

    “An otherwise healthy 31-year-old male experienced sudden onset substernal, non-exertional chest pain within 20 minutes of taking a gummy containing delta-8-THC. Brugada type I pattern was noted on EKG, with notable progression from a baseline EKG 2 months prior that showed Brugada type III pattern. EKG returned to baseline by 16 hours post-ingestion and the Brugada pattern ultimately resolved by one-month follow up.”

    Delta-8-tetrahydrocannabinol (delta-8-thc) · Natural Medicines adverse-effect record, reported in pain.

    3 sources cited
    1. 107323. Jo NY, Chu CC, Ramsey BC. Brugada Electrocardiogram Pattern Induced by Recreational Delta-8-Tetrahydrocannabinol (THC): A Case Report. Cureus 2021;13(10):e19058. PubMed
    2. 113033. Bradley EK, Hoots BE, Bradley ES, Roehler DR. Unintentional ingestion of putative delta-8 tetrahydrocannabinol by two youth requiring critical care: a case report. J Cannabis Res 2023;5(1):9. PubMed
    3. 113042. Shaker K, Nillas A, Ellison R, et al. Delta-8-Tetrahydrocannabinol Exposure and Confirmation in Four Pediatric Patients. J Med Toxicol 2023;19(2):190-195. PubMed

    Insulin Lispro

    Listed in the ADVERSE REACTIONS section of the FDA label for Insulin Lispro. Read the label on DailyMed ›

  • Low blood pressure Additional detail

    Delta-8-tetrahydrocannabinol (delta-8-thc)

    Recorded for Delta-8-tetrahydrocannabinol (delta-8-thc) in the same Natural Medicines adverse-effect record shown under Shortness of breath above.

    Insulin Lispro

    Listed in the ADVERSE REACTIONS section of the FDA label for Insulin Lispro. Read the label on DailyMed ›

Reported for Delta-8-tetrahydrocannabinol (delta-8-thc) but not commonly for Insulin Lispro: a slow heartbeat, hallucinations, drowsiness and chest pain.

Effects for Insulin Lispro come from the ADVERSE REACTIONS section of its FDA label; effects for Delta-8-tetrahydrocannabinol (delta-8-thc) come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Insulin Lispro Products Have a Food Rule — Delta-8-tetrahydrocannabinol (delta-8-thc) Should Not Break It

At least one FDA label for a product containing Insulin Lispro says to take it with food. If you take Delta-8-tetrahydrocannabinol (delta-8-thc) on an empty stomach out of habit, keep them separate — and take Insulin Lispro with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Insulin Lispro products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 , 2.2 , 2.3 , 2.4 ) Subcutaneous injection ( 2.2 ): Administer HUMALOG ® U-100 or U-200 by subcutaneous injection into the abdominal wall, thigh, upper arm, or buttocks within 15 minutes before a meal or immediately after a meal.

From the Dosage and Administration section of the FDA label we read for Insulin Lispro — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Insulin Lispro

This page covers Delta-8-tetrahydrocannabinol (delta-8-thc) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin Lispro page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Insulin Lispro page

“Blood sugar is the entire subject of this list. Insulin lispro (Admelog) is a rapid mealtime insulin dosed to bring glucose down after eating, and the supplements below can shove that same number around, most of them downward, which risks a genuine low.”

Reviewed by 2 · Jul 18, 2026

Open the Insulin Lispro interaction page

How much people look this up

Where Delta-8-tetrahydrocannabinol (delta-8-thc) and Insulin Lispro Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Delta-8-tetrahydrocannabinol (delta-8-thc)
Steady interest

#1,427 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Insulin Lispro
Top half

#1,200 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Delta-8-tetrahydrocannabinol (delta-8-thc) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Delta-8-tetrahydrocannabinol (delta-8-thc) and Insulin Lispro records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Delta-8-tetrahydrocannabinol (delta-8-thc)

What is Delta-8-tetrahydrocannabinol (delta-8-thc)?

  • Relaxation and mild euphoria
  • Anxiety and stress
  • Sleep problems
  • Pain relief
  • Nausea
  • Appetite stimulation

Delta-8-THC is a mind-altering cannabis compound, usually made by chemically converting CBD from hemp, that produces effects similar to but often milder than regular (delta-9) THC. There is very little quality human research on its benefits, and the FDA has warned about safety concerns, unregulated products, and reports of harm. Its legal status varies, and it is not recommended during pregnancy, breastfeeding, or for people who must avoid intoxication.

Cannabinoid derived from hemp (Cannabis sativa) · Gummies, vape cartridges, tinctures, edibles, capsules, flower sprayed with extract

An interaction check asks whether these two react with each other — it does not ask whether Delta-8-tetrahydrocannabinol (delta-8-thc) is a good idea for someone in your situation. Here is what our Delta-8-tetrahydrocannabinol (delta-8-thc) record says about it on its own.

Delta-8-tetrahydrocannabinol (delta-8-thc): dosing

There is no established or standardized safe dose for delta-8-THC. Products vary widely in strength, and because the market is poorly regulated, the amount listed on the label may not match what is actually in the product.If a product is used, the general harm-reduction advice is to "start low and go slow," follow the product label, and wait long enough to feel the effects—edibles in particular can take a couple of hours to kick in, leading some people to take too much.

From our Delta-8-tetrahydrocannabinol (delta-8-thc) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Delta-8-tetrahydrocannabinol (delta-8-thc) monograph & all interactions
Medication

About Insulin Lispro Injection

What Is Insulin Lispro Injection Used For?

Brand names: Admelog, Admelog Solostar

Insulin lispro injection is used to improve glycemic control (blood sugar management) in people with diabetes mellitus. It is a rapid-acting insulin analog approved for use in both type 1 and type 2 diabetes.

Admelog is specifically indicated to improve glycemic control in patients with diabetes mellitus. Humalog Mix75/25 is indicated to improve glycemic control in adults with diabetes mellitus; it is a fixed-ratio mixture of insulin lispro and insulin lispro protamine, and its fixed proportions do not allow for separate adjustment of basal (background) and prandial (mealtime) doses.

See full Insulin Lispro Injection drug information
Keep checking

Other Drugs & Delta-8-tetrahydrocannabinol (delta-8-thc)

Browse every other medication we’ve checked against Delta-8-tetrahydrocannabinol (delta-8-thc) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Delta-8-tetrahydrocannabinol (delta-8-thc) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Delta-8-tetrahydrocannabinol (delta-8-thc) list.

See the full Delta-8-tetrahydrocannabinol (delta-8-thc) interactions page
See every supplement checked against Insulin Lispro, ranked by severity
Evidence & sources

Delta-8-tetrahydrocannabinol (delta-8-thc) References

The 11 references that drive our Delta-8-tetrahydrocannabinol (delta-8-thc) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Johnson-Arbor K, Smolinske S. The current state of delta-8 THC. Am J Emerg Med 2021. PubMed
  2. Rosenthal J, Howell M, Earl V, Malik M. Cannabinoid hyperemesis syndrome secondary to delta-8 THC use. Am J Med 2021. PubMed
  3. US Food and Drug Administration (FDA). 5 things to know about delta-8 tetrahydrocannabinol - delta-8 THC. September 2021. https://www.fda.gov/consumers/consumer-updates/5-things-know-about-delta-8-tetrahydrocannabinol-delta-8-thc. Accessed October 2, 2021
  4. Centers for Disease Control and Prevention (CDC). Increases in availability of cannabis products containing delta-8 THC and reported cases of adverse events. September 2021. https://emergency.cdc.gov/han/2021/han00451.asp. Accessed October 2, 2021.
  5. Akpunonu P, Baum RA, Reckers A, et al. Sedation and Acute Encephalopathy in a Pediatric Patient Following Ingestion of Delta-8-Tetrahydrocannabinol Gummies. Am J Case Rep 2021;22:e933488. PubMed
  6. Jo NY, Chu CC, Ramsey BC. Brugada Electrocardiogram Pattern Induced by Recreational Delta-8-Tetrahydrocannabinol (THC): A Case Report. Cureus 2021;13(10):e19058. PubMed
  7. Leas EC, Harati RM, Satybaldiyeva N, et al. Self-reported adverse events associated with ?(8)-Tetrahydrocannabinol (Delta-8-THC) Use. J Cannabis Res 2023;5(1):15. PubMed
  8. Simon TA, Simon JH, Heaning EG, Gomez-Caminero A, Marcu JP. Delta-8, a Cannabis-Derived Tetrahydrocannabinol Isomer: Evaluating Case Report Data in the Food and Drug Administration Adverse Event Reporting System (FAERS) Database. Drug Healthc Patient Saf PubMed
  9. Bradley EK, Hoots BE, Bradley ES, Roehler DR. Unintentional ingestion of putative delta-8 tetrahydrocannabinol by two youth requiring critical care: a case report. J Cannabis Res 2023;5(1):9. PubMed
  10. Shaker K, Nillas A, Ellison R, et al. Delta-8-Tetrahydrocannabinol Exposure and Confirmation in Four Pediatric Patients. J Med Toxicol 2023;19(2):190-195. PubMed
  11. Miller CR, Burk BG, Fargason RE, Birur B. Delta-8-THC association with psychosis: A case report with literature review. Front Psychiatry 2023;14:1103123. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Delta-8-tetrahydrocannabinol (delta-8-thc) and Insulin Lispro Together: Common Questions

Is it safe to take Delta-8-tetrahydrocannabinol (delta-8-thc) with Insulin Lispro?
We do not list a known interaction between Delta-8-tetrahydrocannabinol (delta-8-thc) and Insulin Lispro. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Delta-8-tetrahydrocannabinol (delta-8-thc) and Insulin Lispro have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Delta-8-tetrahydrocannabinol (delta-8-thc) and Insulin Lispro at the same time of day?
At least one FDA label for a product containing Insulin Lispro says to take it with food. If you take Delta-8-tetrahydrocannabinol (delta-8-thc) on an empty stomach out of habit, keep them separate and take Insulin Lispro with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Insulin Lispro products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Insulin Lispro interact with any supplements?
Yes. Insulin Lispro has documented interactions with 239 supplements in our database — Delta-8-tetrahydrocannabinol (delta-8-thc) is not one of them. The Insulin Lispro interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Delta-8-tetrahydrocannabinol (delta-8-thc) monograph Uses, safety profile, and every drug interaction in one place Insulin Lispro Injection drug information The full plain-English guide to this medication Insulin Lispro supplement interactions Every supplement checked against Insulin Lispro, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 11 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Insulin Lispro and Delta-8-tetrahydrocannabinol (delta-8-thc)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.