Delta-8-tetrahydrocannabinol (delta-8-thc) + Salmeterol
Salmeterol brand name: Serevent.
We found no known interaction between Delta-8-tetrahydrocannabinol (delta-8-thc) and Salmeterol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Salmeterol states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Delta-8-tetrahydrocannabinol (delta-8-thc) and Salmeterol
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Salmeterol and Delta-8-tetrahydrocannabinol (delta-8-thc) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Delta-8-tetrahydrocannabinol (delta-8-thc) at all — not against Salmeterol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Delta-8-tetrahydrocannabinol (delta-8-thc) safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Salmeterol Products Have a Food Rule — Delta-8-tetrahydrocannabinol (delta-8-thc) Should Not Break It
At least one FDA label for a product containing Salmeterol says to take it on an empty stomach. Most supplements — Delta-8-tetrahydrocannabinol (delta-8-thc) included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Salmeterol on its own and move Delta-8-tetrahydrocannabinol (delta-8-thc) to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Salmeterol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
One inhalation of SEREVENT DISKUS at least 30 minutes before exercise has been shown to protect patients against EIB.
From the Dosage and Administration section of the FDA label we read for Salmeterol — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Salmeterol
This page covers Delta-8-tetrahydrocannabinol (delta-8-thc) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Salmeterol page lists 141 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: American Hellebore (major), Arsenic (major), Cesium (major), Ephedra (major) and Grapefruit (major).
By severity: 7 major · 105 moderate · 29 minor.
From our pharmacist’s overview on the Salmeterol page
“Salmeterol (Serevent) is the long-acting inhaler taken twice daily for asthma or COPD, and its supplement list is one I would approach with real caution. Seven of the 141 ingredients on file rate major: grapefruit can raise salmeterol levels by blocking the enzyme that clears it, St.”
Reviewed by 2 · Jul 18, 2026
Where Delta-8-tetrahydrocannabinol (delta-8-thc) and Salmeterol Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,288 of 1,452 supplements looked up here in the last 7 days
#1,222 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Delta-8-tetrahydrocannabinol (delta-8-thc) reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Delta-8-tetrahydrocannabinol (delta-8-thc) and Salmeterol records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Delta-8-tetrahydrocannabinol (delta-8-thc)
What is Delta-8-tetrahydrocannabinol (delta-8-thc)?
- Relaxation and mild euphoria
- Anxiety and stress
- Sleep problems
- Pain relief
- Nausea
- Appetite stimulation
Delta-8-THC is a mind-altering cannabis compound, usually made by chemically converting CBD from hemp, that produces effects similar to but often milder than regular (delta-9) THC. There is very little quality human research on its benefits, and the FDA has warned about safety concerns, unregulated products, and reports of harm. Its legal status varies, and it is not recommended during pregnancy, breastfeeding, or for people who must avoid intoxication.
Cannabinoid derived from hemp (Cannabis sativa) · Gummies, vape cartridges, tinctures, edibles, capsules, flower sprayed with extract
An interaction check asks whether these two react with each other — it does not ask whether Delta-8-tetrahydrocannabinol (delta-8-thc) is a good idea for someone in your situation. Here is what our Delta-8-tetrahydrocannabinol (delta-8-thc) record says about it on its own.
Delta-8-tetrahydrocannabinol (delta-8-thc): dosing
There is no established or standardized safe dose for delta-8-THC. Products vary widely in strength, and because the market is poorly regulated, the amount listed on the label may not match what is actually in the product.If a product is used, the general harm-reduction advice is to "start low and go slow," follow the product label, and wait long enough to feel the effects—edibles in particular can take a couple of hours to kick in, leading some people to take too much.
From our Delta-8-tetrahydrocannabinol (delta-8-thc) monograph — the full record covers uses, side effects and every documented interaction.
About Salmeterol Oral Inhalation
What Is Salmeterol Oral Inhalation Used For?
Brand name: Serevent
Serevent Diskus (salmeterol inhalation powder) is used for three main purposes: treating asthma in patients aged 4 and older alongside an inhaled corticosteroid (ICS), preventing exercise-induced bronchospasm (EIB) in patients aged 4 and older, and providing long-term maintenance treatment of bronchospasm associated with COPD — including chronic bronchitis and emphysema — in adults.
Important: Serevent Diskus is not a rescue inhaler. It will not relieve a sudden asthma or COPD attack. For asthma, it must always be used together with an inhaled corticosteroid — using it alone for asthma is contraindicated due to a serious risk of asthma-related death.
Other Drugs & Delta-8-tetrahydrocannabinol (delta-8-thc)
Browse every other medication we’ve checked against Delta-8-tetrahydrocannabinol (delta-8-thc) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Delta-8-tetrahydrocannabinol (delta-8-thc) against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Acetaminophen ›
- Rivaroxaban ›
- Rosuvastatin ›
- Abemaciclib ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Hydroxyurea ›
- Methamphetamine ›
- Valacyclovir ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Amitriptyline ›
- Bupropion ›
- Methotrexate ›
- Bendamustine ›
- Isotretinoin ›
- Amphetamine ›
- Amlodipine Besylate ›
- Acyclovir ›
- Doxycycline ›
- Fluoxetine ›
- Pregabalin ›
- Lamotrigine ›
- Azithromycin ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Dextroamphetamine ›
- Clonazepam ›
- Quetiapine ›
- Methylene Blue ›
- Omeprazole ›
- Letrozole ›
- Naproxen ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Delta-8-tetrahydrocannabinol (delta-8-thc) list.
Delta-8-tetrahydrocannabinol (delta-8-thc) References
The 11 references that drive our Delta-8-tetrahydrocannabinol (delta-8-thc) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Johnson-Arbor K, Smolinske S. The current state of delta-8 THC. Am J Emerg Med 2021. PubMed
- Rosenthal J, Howell M, Earl V, Malik M. Cannabinoid hyperemesis syndrome secondary to delta-8 THC use. Am J Med 2021. PubMed
- US Food and Drug Administration (FDA). 5 things to know about delta-8 tetrahydrocannabinol - delta-8 THC. September 2021. https://www.fda.gov/consumers/consumer-updates/5-things-know-about-delta-8-tetrahydrocannabinol-delta-8-thc. Accessed October 2, 2021
- Centers for Disease Control and Prevention (CDC). Increases in availability of cannabis products containing delta-8 THC and reported cases of adverse events. September 2021. https://emergency.cdc.gov/han/2021/han00451.asp. Accessed October 2, 2021.
- Akpunonu P, Baum RA, Reckers A, et al. Sedation and Acute Encephalopathy in a Pediatric Patient Following Ingestion of Delta-8-Tetrahydrocannabinol Gummies. Am J Case Rep 2021;22:e933488. PubMed
- Jo NY, Chu CC, Ramsey BC. Brugada Electrocardiogram Pattern Induced by Recreational Delta-8-Tetrahydrocannabinol (THC): A Case Report. Cureus 2021;13(10):e19058. PubMed
- Leas EC, Harati RM, Satybaldiyeva N, et al. Self-reported adverse events associated with ?(8)-Tetrahydrocannabinol (Delta-8-THC) Use. J Cannabis Res 2023;5(1):15. PubMed
- Simon TA, Simon JH, Heaning EG, Gomez-Caminero A, Marcu JP. Delta-8, a Cannabis-Derived Tetrahydrocannabinol Isomer: Evaluating Case Report Data in the Food and Drug Administration Adverse Event Reporting System (FAERS) Database. Drug Healthc Patient Saf PubMed
- Bradley EK, Hoots BE, Bradley ES, Roehler DR. Unintentional ingestion of putative delta-8 tetrahydrocannabinol by two youth requiring critical care: a case report. J Cannabis Res 2023;5(1):9. PubMed
- Shaker K, Nillas A, Ellison R, et al. Delta-8-Tetrahydrocannabinol Exposure and Confirmation in Four Pediatric Patients. J Med Toxicol 2023;19(2):190-195. PubMed
- Miller CR, Burk BG, Fargason RE, Birur B. Delta-8-THC association with psychosis: A case report with literature review. Front Psychiatry 2023;14:1103123. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Delta-8-tetrahydrocannabinol (delta-8-thc) and Salmeterol Together: Common Questions
Is it safe to take Delta-8-tetrahydrocannabinol (delta-8-thc) with Salmeterol?
Do Delta-8-tetrahydrocannabinol (delta-8-thc) and Salmeterol have any of the same side effects?
Should I take Delta-8-tetrahydrocannabinol (delta-8-thc) and Salmeterol at the same time of day?
Does Salmeterol interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Salmeterol and Delta-8-tetrahydrocannabinol (delta-8-thc)?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.