Drug & supplement interaction

Devil's Club + Acetaminophen

Acetaminophen brand names: Tylenol Ex Strength, Children's Tylenol, Tylenol, Children's Tylenol Meltaways.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Devil's Club and Acetaminophen in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Devil's Club and Acetaminophen

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Acetaminophen and Devil's Club in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Devil's Club at all — not against Acetaminophen, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Devil's Club safety at a glance

Devil's Club overall Use caution Limited human safety data exist, so use cautiously and under professional guidance.
Pregnancy Avoid Not enough safety information is available, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety has not been studied in nursing mothers, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Acetaminophen and Devil's Club? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Devil's Club and Acetaminophen May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Devil's Club

    “Orally, devil's club might cause diarrhea, nausea, vomiting, and lightheadedness. Topically, devil's club might cause allergic reactions.”

    Devil's Club · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 95732. Thommasen HV, Wilson RA, McIlwain RG. Effect of Devil's Club Tea on Blood Glucose Levels in Diabetes Mellitus. Can Fam Physician. 1990;36:62-5.
    2. 47178. Turner NJ, Thompson LC Thompson MT York AZ. Thompson Ethnobotany: Knowledge and Usage of Plants by the Thompson Indians of British Columbia. 1990.

    Acetaminophen

    Listed in the ADVERSE REACTIONS section of the FDA label for Acetaminophen. Read the label on DailyMed ›

  • Nausea / Diarrhea / Vomiting reported in 6.2% of FDA reports for Acetaminophen Additional detail

    Devil's Club

    “Orally, nausea and vomiting has been reported for an otherwise healthy patient who drank two 80-mL servings of devil's club 5 hours apart. The tea was prepared by boiling devil's club root, bark, and berries for 4-6 hours. Diarrhea and nausea have been reported in some individuals after chewing and swallowing the inner bark of 40 sticks of devil's club.”

    Devil's Club · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 95732. Thommasen HV, Wilson RA, McIlwain RG. Effect of Devil's Club Tea on Blood Glucose Levels in Diabetes Mellitus. Can Fam Physician. 1990;36:62-5.

    Acetaminophen

    Listed in the ADVERSE REACTIONS section of the FDA label for Acetaminophen, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Devil's Club but not commonly for Acetaminophen: dizziness.

Effects for Acetaminophen come from the ADVERSE REACTIONS section of its FDA label; effects for Devil's Club come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 679,604 voluntary FDA FAERS reports for Acetaminophen that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Devil's Club or Acetaminophen

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Devil's Club or Acetaminophen, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Acetaminophen

This page covers Devil's Club only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen page lists 155 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 114 moderate · 36 minor.

From our pharmacist’s overview on the Acetaminophen page

“Acetaminophen (Tylenol) feels harmless because it sits on every shelf, but this list deserves real attention, mostly because of your liver. Of the 155 supplements and herbs on file, five carry a major rating, and the largest serious group, 38 ingredients, adds liver strain on top of acetaminophen's own well-known potential to harm the…”

Reviewed by 2 · Jul 18, 2026

Open the Acetaminophen interaction page

One more smart check

Taking Devil's Club as Part of a Dietary Supplement Product? Check It for Interactions

We hold 48 real supplement products containing Devil's Club, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Devil's Club. Even though Devil's Club itself has no known interaction with Acetaminophen, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Devil's Club and Acetaminophen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Devil's Club
Steady interest

#1,234 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetaminophen
Top 1%

#26 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Devil's Club reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Devil's Club and Acetaminophen records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Devil's Club

What is Devil's Club?

  • Blood sugar support
  • Respiratory and cold symptoms
  • Arthritis and joint pain
  • Digestive complaints
  • General tonic and wellness

Devil's Club is a thorny shrub from the Pacific Northwest of North America that has long been used in Indigenous traditional medicine, especially for blood sugar and respiratory complaints. Scientific evidence in humans is very limited, so its benefits are not proven. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Oplopanax horridus · Araliaceae · Root bark, stem bark, and inner bark · Tea or decoction, tincture, capsules, dried bark, topical salves

An interaction check asks whether these two react with each other — it does not ask whether Devil's Club is a good idea for someone in your situation. Here is what our Devil's Club record says about it on its own.

Devil's Club: dosing

There is no established standard dose for Devil's Club. The right amount has not been determined in clinical studies, and product strength can vary widely between brands and forms (tea, tincture, or capsule).If you choose to use it, follow the directions on the product label and do not exceed the suggested amount.

From our Devil's Club monograph — the full record covers uses, side effects and every documented interaction.

Read the full Devil's Club monograph & all interactions
Medication

About Acetaminophen

What Is Acetaminophen Used For?

Brand names: Tylenol Ex Strength, Children's Tylenol, Tylenol, Children's Tylenol Meltaways

Acetaminophen temporarily relieves minor aches and pains caused by headaches, the common cold, backaches, muscle aches, toothaches, minor arthritis pain, and premenstrual or menstrual cramps. It also temporarily reduces fever.

These uses apply across oral tablet, suspension, and oral liquid products. The intravenous (IV) injection form is used in clinical settings to treat acute pain and fever, including in pediatric patients 2 years and older.

Most-Reported Side Effects for Acetaminophen

From FAERS, the FDA’s public side-effect reporting system (679,604 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 45,791 reports
Nausea 41,932 reports
Overdose 40,941 reports
Drug dependence 39,209 reports
Headache 38,738 reports
See full Acetaminophen drug information
Keep checking

Other Drugs & Devil's Club

Browse every other medication we’ve checked against Devil's Club — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Devil's Club against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Devil's Club list.

See the full Devil's Club interactions page
See every supplement checked against Acetaminophen, ranked by severity
Evidence & sources

Devil's Club References

The 2 references that drive our Devil's Club monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Turner NJ, Thompson LC Thompson MT York AZ. Thompson Ethnobotany: Knowledge and Usage of Plants by the Thompson Indians of British Columbia. 1990.
  2. Thommasen HV, Wilson RA, McIlwain RG. Effect of Devil's Club Tea on Blood Glucose Levels in Diabetes Mellitus. Can Fam Physician. 1990;36:62-5.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Devil's Club and Acetaminophen Together: Common Questions

Is it safe to take Devil's Club with Acetaminophen?
We do not list a known interaction between Devil's Club and Acetaminophen. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Devil's Club and Acetaminophen have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Acetaminophen interact with any supplements?
Yes. Acetaminophen has documented interactions with 155 supplements in our database — Devil's Club is not one of them. The Acetaminophen interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Devil's Club monograph Uses, safety profile, and every drug interaction in one place Acetaminophen drug information The full plain-English guide to this medication Acetaminophen supplement interactions Every supplement checked against Acetaminophen, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Acetaminophen and Devil's Club?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.