Devil's Club + Prednisone
Prednisone brand names: Deltasone, Cortan, Orasone, Prednisone, Prednicen-M, and others.
We found no known interaction between Devil's Club and Prednisone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Prednisone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Devil's Club and Prednisone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Prednisone and Devil's Club in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Devil's Club at all — not against Prednisone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Devil's Club safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Prednisone Products Have a Food Rule — Devil's Club Should Not Break It
At least one FDA label for a product containing Prednisone says to take it with food. If you take Devil's Club on an empty stomach out of habit, keep them separate — and take Prednisone with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Prednisone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
DOSAGE AND ADMINISTRATION Gastric irritation may be reduced if taken before, during, or immediately after meals or with food or milk.
From the Dosage and Administration section of the FDA label we read for Prednisone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
Questions About Devil's Club or Prednisone
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Devil's Club or Prednisone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Does Prednisone Stop Cough or Clear Mucus? ›
- Does Activated Charcoal Remove Dexamethasone From the Body? ›
- Concerns Taking Prednisone With Other Drugs For Ménière's Disease ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Prednisone
This page covers Devil's Club only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Prednisone page lists 208 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lily-of-the-valley (major), St. John's Wort (major) and Acacia Rigidula (moderate).
By severity: 4 major · 168 moderate · 36 minor.
From our pharmacist’s overview on the Prednisone page
“Prednisone (Deltasone) suppresses the immune system to control inflammation, and that mechanism shapes most of what can go wrong on this 208-ingredient list, which I read as one to approach carefully rather than casually. Four entries rate major.”
Reviewed by 2 · Jul 18, 2026
Taking Devil's Club as Part of a Dietary Supplement Product? Check It for Interactions
We hold 48 real supplement products containing Devil's Club, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Devil's Club. Even though Devil's Club itself has no known interaction with Prednisone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Devil's Club and Prednisone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,237 of 1,452 supplements looked up here in the last 7 days
#22 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Devil's Club reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Devil's Club and Prednisone records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Devil's Club
What is Devil's Club?
- Blood sugar support
- Respiratory and cold symptoms
- Arthritis and joint pain
- Digestive complaints
- General tonic and wellness
Devil's Club is a thorny shrub from the Pacific Northwest of North America that has long been used in Indigenous traditional medicine, especially for blood sugar and respiratory complaints. Scientific evidence in humans is very limited, so its benefits are not proven. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
Oplopanax horridus · Araliaceae · Root bark, stem bark, and inner bark · Tea or decoction, tincture, capsules, dried bark, topical salves
An interaction check asks whether these two react with each other — it does not ask whether Devil's Club is a good idea for someone in your situation. Here is what our Devil's Club record says about it on its own.
Devil's Club: dosing
There is no established standard dose for Devil's Club. The right amount has not been determined in clinical studies, and product strength can vary widely between brands and forms (tea, tincture, or capsule).If you choose to use it, follow the directions on the product label and do not exceed the suggested amount.
From our Devil's Club monograph — the full record covers uses, side effects and every documented interaction.
About Prednisone
What Is Prednisone Used For?
Brand names: Deltasone, Cortan, Orasone, Prednisone, Prednicen-M, Meticorten, Sterapred, Rayos
Prednisone treats a broad range of conditions where the body's immune system is overactive or inflammation needs to be controlled. It works across many organ systems, from the lungs and skin to the joints and blood.
Doctors prescribe it for conditions like asthma, severe allergies, Crohn's disease, multiple sclerosis flares, certain cancers, and to prevent organ rejection after transplant, among many others.
Most-Reported Side Effects for Prednisone
From FAERS, the FDA’s public side-effect reporting system (499,938 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Devil's Club
Browse every other medication we’ve checked against Devil's Club — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Devil's Club against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Ibuprofen ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Devil's Club list.
Devil's Club References
The 2 references that drive our Devil's Club monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Turner NJ, Thompson LC Thompson MT York AZ. Thompson Ethnobotany: Knowledge and Usage of Plants by the Thompson Indians of British Columbia. 1990.
- Thommasen HV, Wilson RA, McIlwain RG. Effect of Devil's Club Tea on Blood Glucose Levels in Diabetes Mellitus. Can Fam Physician. 1990;36:62-5.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Prednisone Is Linked to Lower Levels of 8 Nutrients
Natural Medicines records Prednisone as a medicine that can lower these. This is not an interaction with Devil's Club — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Prednisone nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Devil's Club and Prednisone Together: Common Questions
Is it safe to take Devil's Club with Prednisone?
Do Devil's Club and Prednisone have any of the same side effects?
Should I take Devil's Club and Prednisone at the same time of day?
Does Prednisone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Prednisone and Devil's Club?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.