Drug & supplement interaction

Elecampane + Acetaminophen, Dichloralphenazone, Isometheptene

Acetaminophen, Dichloralphenazone, Isometheptene brand name: Midrin.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Elecampane has a moderate interaction with Acetaminophen, Dichloralphenazone, Isometheptene. Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Elecampane and Acetaminophen, Dichloralphenazone, Isometheptene

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CNS DEPRESSANTS

Why this applies to Acetaminophen, Dichloralphenazone, Isometheptene

Acetaminophen, Dichloralphenazone, Isometheptene falls under CNS DEPRESSANTS — the group Elecampane interacts with.

Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Elecampane might have sedative effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing about Midrin: one of its three ingredients, dichloralphenazone, is a mild sedative that can already leave you feeling drowsy or a little foggy. Elecampane, the cough and digestion herb you're asking about, is thought to have some calming, sedative-like effects of its own.

So the concern is simple stacking: taking them together could in theory add up to more sleepiness, slower reactions, or feeling groggy and dizzy. I want to be honest though, this is a theoretical caution based on how the two might behave, not on solid human studies, so it may not amount to much in real life. Still, if you do try both, go easy until you know how you feel, skip driving, and check in with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Elecampane Also Interacts With Other Medications

Elecampane has 247 moderate known drug interactions in our database — the Acetaminophen, Dichloralphenazone, Isometheptene one above is one of them. If you take anything else, check it against the full list below.

Moderate 247 No known interaction 2,583 (incl. Acetaminophen, Dichloralphenazone, Isometheptene)
Taking anything else?

Check Another of Your Medications Against Elecampane

Covers the 2,830 medications we’ve checked against Elecampane. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Acetaminophen, Dichloralphenazone, Isometheptene

This page covers Elecampane only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Dichloralphenazone, Isometheptene page lists 250 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Ephedra (major).

By severity: 13 major · 196 moderate · 41 minor.

From our pharmacist’s overview on the Acetaminophen, Dichloralphenazone, Isometheptene page

“Midrin pairs acetaminophen with a sedative (dichloralphenazone) and a stimulant-like blood vessel constrictor (isometheptene), so it can be pushed off course from several directions, and I would approach this list with real vigilance. Thirteen of the 250 ingredients listed are rated major, and most of those either deepen the sedation,…”

Reviewed by 2 · Jul 18, 2026

Open the Acetaminophen, Dichloralphenazone, Isometheptene interaction page

One more smart check

Taking Elecampane as Part of a Dietary Supplement Product? Check It for Interactions

We hold 332 real supplement products containing Elecampane, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Elecampane. Your product may carry other ingredients that interact with Acetaminophen, Dichloralphenazone, Isometheptene too, on top of Elecampane — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Elecampane and Acetaminophen, Dichloralphenazone, Isometheptene Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Elecampane
Top half

#434 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetaminophen, Dichloralphenazone, Isometheptene
Top 25%

#418 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Elecampane

What is Elecampane?

Elecampane
  • Cough and bronchitis
  • Asthma symptoms
  • Loosening mucus (expectorant)
  • Digestive upset
  • Intestinal worms (traditional)

Elecampane is a traditional herb used mainly for coughs and other respiratory complaints, and as a bitter for digestion. Modern human evidence is very limited, so it should be seen as a folk remedy rather than a proven treatment. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Read the full Elecampane monograph & all interactions
Keep checking

Other Drugs & Elecampane

Browse every other medication we’ve checked against Elecampane — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
247Moderate
0Minor
2,582No known interaction
247 Moderate 2,582 No interaction
Moderate

247 interactions

Showing 60 of 247 moderate interactions — see all 247 on the Elecampane page.

No interaction 2,582 drugs checked — show the list

We also checked Elecampane against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,582 medications checked with no known interaction — see the full Elecampane list.

See the full Elecampane interactions page
See every supplement checked against Acetaminophen, Dichloralphenazone, Isometheptene, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Elecampane monograph › Uses, safety, and every drug interaction in one place Acetaminophen, Dichloralphenazone, Isometheptene supplement interactions › Every supplement checked against Acetaminophen, Dichloralphenazone, Isometheptene, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Elecampane and Acetaminophen, Dichloralphenazone, Isometheptene Together: Common Questions

Can you take Elecampane with Acetaminophen, Dichloralphenazone, Isometheptene?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Elecampane and Acetaminophen, Dichloralphenazone, Isometheptene interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Acetaminophen, Dichloralphenazone, Isometheptene and Elecampane?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.