Medication interaction hub

What Supplements Interact with Acetaminophen, Dichloralphenazone, Isometheptene?

Acetaminophen, Dichloralphenazone, Isometheptene brand name: Midrin. Every interaction below applies to the brands too.

250 Interactions 13 Major 196 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Dichloralphenazone, Isometheptene? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetaminophen, Dichloralphenazone, Isometheptene against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Midrin pairs acetaminophen with a sedative (dichloralphenazone) and a stimulant-like blood vessel constrictor (isometheptene), so it can be pushed off course from several directions, and I would approach this list with real vigilance. Thirteen of the 250 ingredients listed are rated major, and most of those either deepen the sedation, as alcohol does, or add stimulant strain on blood pressure and the heart. A couple can harm the kidneys, and activated charcoal can bind the drug in your gut and blunt its absorption.

The other entries, 196 moderate and 41 minor, mostly echo the same themes at lower volume. Everyday caffeine adds to the stimulant side, while dozens of herbs share the liver pathways that break down acetaminophen or can tax the liver themselves. Start with the 13 major entries below; anything that makes you drowsy or wired on its own will likely do the same on top of this drug.

— , Clinical Pharmacist · July 18, 2026

Major 13 Moderate 196 Minor 41 No known interaction 1,202

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Acetaminophen, Dichloralphenazone, Isometheptene: Top Interactions at a Glance

The most significant Acetaminophen, Dichloralphenazone, Isometheptene supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 250 interacting ingredients — plus 1,202 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Acetaminophen, Dichloralphenazone, Isometheptene + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Acetaminophen, Dichloralphenazone, Isometheptenei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Acetaminophen, Dichloralphenazone, Isometheptenei

Siberian cocklebur can adversely affect the kidney.

Read the full interaction Major Likelihood Likely Wine + Acetaminophen, Dichloralphenazone, Isometheptenei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Acetaminophen, Dichloralphenazone, Isometheptenei

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Acetaminophen, Dichloralphenazone, Isometheptenei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Ephedra + Acetaminophen, Dichloralphenazone, Isometheptenei

Theoretically, concomitant use might increase the risk for serious adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Acetaminophen, Dichloralphenazone, Isometheptene

All 1,452 ingredients in our database, ranked by severity — 250 with a Acetaminophen, Dichloralphenazone, Isometheptene interaction on file and 1,202 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetaminophen, Dichloralphenazone, Isometheptene?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Baikal Skullcap with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.

Full Baikal Skullcap + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Calea Zacatechichi with Acetaminophen, Dichloralphenazone, Isometheptene?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Calea zacatechichi might increase the sedative effects of CNS depressants.

Full Calea Zacatechichi + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take California Poppy with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking California poppy with drugs with sedative effects may increase the risk of sedative effects.

Full California Poppy + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Cauliflower with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical evidence suggests that eating cruciferous vegetables, including broccoli, cauliflower, daikon radish sprouts, and cabba...

Full Cauliflower + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Celery with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, celery might increase levels of drugs metabolized by CYP1A2.

Full Celery + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Ceylon Leadwort with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.

Full Ceylon Leadwort + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Chanca Piedra with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.

Full Chanca Piedra + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Chaparral with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Chaparral + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Clove with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.

Full Clove + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Cnidium with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In laboratory research, cnidium has been shown to have sedative and hypnotic effects, possibly related to constituent coumarins.

Full Cnidium + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Comfrey with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Comfrey + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Coriander with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.

Full Coriander + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Corn Poppy with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of corn poppy with CNS depressants might increase the risk of sedation.

Full Corn Poppy + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Corydalis Yanhusuo with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase the sedative effects of CNS depressants.

Full Corydalis Yanhusuo + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Dandelion with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.

Full Dandelion + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Danshen with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP1A2.

Full Danshen + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might have additive effects if used with other CNS depressants.

Full Delta-9-tetrahydrocannabinol (thc) + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Dimethylhexylamine (dmha) with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining DMHA with stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Dimethylhexylamine (dmha) + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Diosmin with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP2E1 substrates.

Full Diosmin + Acetaminophen, Dichloralphenazone, Isometheptene answer

Can you take Echinacea with Acetaminophen, Dichloralphenazone, Isometheptene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.

Full Echinacea + Acetaminophen, Dichloralphenazone, Isometheptene answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetaminophen, Dichloralphenazone, Isometheptene is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Dichloralphenazone, Isometheptene, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetaminophen, Dichloralphenazone, Isometheptene sits in 10 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Acetaminophen, Dichloralphenazone, Isometheptene through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Acetaminophen, Dichloralphenazone, Isometheptene through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Acetaminophen, Dichloralphenazone, Isometheptene through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetaminophen, Dichloralphenazone, Isometheptene through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Acetaminophen, Dichloralphenazone, Isometheptene through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Dichloralphenazone, Isometheptene through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Dichloralphenazone, Isometheptene through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Acetaminophen, Dichloralphenazone, Isometheptene through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Dichloralphenazone, Isometheptene through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Acetaminophen, Dichloralphenazone, Isometheptene through this category.

Related: does Acetaminophen, Dichloralphenazone, Isometheptene deplete any nutrients?

Acetaminophen, Dichloralphenazone, Isometheptene has 1 reported nutrient association in the research literature — see the Acetaminophen, Dichloralphenazone, Isometheptene nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Dichloralphenazone, Isometheptene

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Dichloralphenazone, Isometheptene.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Products that contain Acetaminophen, Dichloralphenazone, Isometheptene-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Acetaminophen, Dichloralphenazone, Isometheptene.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Acetaminophen, Dichloralphenazone, Isometheptene & Supplements: Common Questions

What supplements interact with Acetaminophen, Dichloralphenazone, Isometheptene?
More than you might expect — 250 in total, though they are far from equal: 13 are rated major, 196 moderate, and 41 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Siberian Cocklebur, Wine.
Which Acetaminophen, Dichloralphenazone, Isometheptene supplement interactions are the most serious?
The 13 major-rated combinations — led by Beer, Siberian Cocklebur, Wine, 1,4-butanediol and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Acetaminophen, Dichloralphenazone, Isometheptene?
Usually yes — most people on Acetaminophen, Dichloralphenazone, Isometheptene can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Midrin have the same supplement interactions as Acetaminophen, Dichloralphenazone, Isometheptene?
Yes — Midrin all contain Acetaminophen, Dichloralphenazone, Isometheptene, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetaminophen, Dichloralphenazone, Isometheptene deplete any vitamins or nutrients?
It might — Acetaminophen, Dichloralphenazone, Isometheptene has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetaminophen, Dichloralphenazone, Isometheptene nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetaminophen, Dichloralphenazone, Isometheptene and my other medications?
This page covers Acetaminophen, Dichloralphenazone, Isometheptene against supplements and herbal ingredients. Checking Acetaminophen, Dichloralphenazone, Isometheptene against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.