Drug & supplement interaction

Fish Oil + Guaifenesin, Hydrocodone

Guaifenesin, Hydrocodone brand names: Pneumotussin, Entuss.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Fish Oil and Guaifenesin, Hydrocodone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Fish Oil and Guaifenesin, Hydrocodone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Guaifenesin, Hydrocodone and Fish Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fish Oil safety at a glance

Fish Oil overall Generally safe Fish oil is generally well tolerated for most adults at typical supplement doses.
Pregnancy Likely Safe When used orally and appropriately. Intake of fish oil during pregnancy does not appear to adversely affect the fetus or nursing infant. One large clinical tria... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally and appropriately. Intake of fish oil during pregnancy does not appear to adversely affect the fetus or nursing infant. One large clinical tria... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Guaifenesin, Hydrocodone and Fish Oil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Guaifenesin, Hydrocodone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Guaifenesin, Hydrocodone is filed under 6 classifications — including narcotic drugs, cytochrome p450 2d6 (cyp2d6) substrates, cns depressants. Fish Oil has documented interactions with 9 drug classes — the most serious being antihypertensive drugs (moderate), contraceptive drugs (moderate) and cyclosporine (neoral, sandimmune) (moderate) — and none of Guaifenesin, Hydrocodone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Fish Oil Does Interact With Other Medications

Fish Oil has 207 moderate, 120 minor known drug interactions in our database — Guaifenesin, Hydrocodone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 207 Minor 120 No known interaction 2,503 (incl. Guaifenesin, Hydrocodone)
Taking anything else?

Check Another of Your Medications Against Fish Oil

Covers the 2,830 medications we’ve checked against Fish Oil. Pick one to open its full report.

What to actually watch for

What Fish Oil Itself Has Been Linked To

This is not an interaction — nothing below involves Guaifenesin, Hydrocodone. It is the side-effect record for Fish Oil on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Fish Oil, this list is the first place to look. 7 entries are worth acting on rather than waiting out — marked below.

  • A heart attack Worth acting on Additional detail

    “Orally, fish oil supplements in doses of 3-10 grams daily can cause a dose-dependent increase in low-density lipoprotein (LDL) cholesterol levels in some people by increasing the size of LDL particles. Therefore, LDL levels should be monitored in people who take fish oil supplements.”

    Fish Oil · Natural Medicines adverse-effect record, reported in atherosclerosis.

    6 sources cited
    1. 2299. Montori VM, Farmer A, Wollan PC, Dinneen SF. Fish oil supplementation in type 2 diabetes: a quantitative systemic review (abstract). Diabetes Care 2000;23:1407-15.
    2. 2318. Adler A, Holub BJ. Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men. Am J Clin Nutr 1997;65:445-50. PubMed
    3. 8678. Dewailly E, Blanchet C, Lemieux S, et al. n-3 Fatty acids and cardiovascular disease risk factors among the Inuit of Nunavik. Am J Clin Nutr 2001;74:464-73. PubMed
    4. 8698. Lacaille B, Julien P, Deshaies Y, et al. Responses of plasma lipoproteins and sex hormones to the consumption of lean fish incorporated in a prudent-type diet in normolipidemic men. J Am Coll Nutr 2000;19:745-53. PubMed
    5. 15734. McKenney JM, Sica D. Prescription omega-3 fatty acids for the treatment of hypertriglyceridemia. Am J Health-Syst Pharm 2007;64:595-605. PubMed
    6. 15735. Malinowski JM, Metka K. Elevation of low-density lipoprotein cholesterol concentration with over-the-counter fish oil supplementation. Ann Pharmacother 2007;41:1296-300. PubMed
  • Wheezing Worth acting on Additional detail

    “Orally, fish oil has been reported to cause nasopharyngitis and upper respiratory tract infections in 3.3% of patients in one clinical trial. Exacerbation of asthma and apnea have been reported for patients using fish oil.”

    Fish Oil · Natural Medicines adverse-effect record, reported in asthma.

    5 sources cited
    1. 65798. Davidson, M. H., Stein, E. A., Bays, H. E., Maki, K. C., Doyle, R. T., Shalwitz, R. A., Ballantyne, C. M., and Ginsberg, H. N. Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patie
    2. 1040. Hawthorne AB, Daneshmend TK, Hawkey CJ, et al. Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. Gut 1992;33:922-8. PubMed
    3. 66061. Turner, D., Shah, P. S., Steinhart, A. H., Zlotkin, S., and Griffiths, A. M. Maintenance of remission in inflammatory bowel disease using omega-3 fatty acids (fish oil): a systematic review and meta-analyses. Inflamm.Bowel.Dis. 2011;17(1):336-345. PubMed
    4. 66119. Oliver, C. and Jahnke, N. Omega-3 fatty acids for cystic fibrosis. Cochrane.Database.Syst.Rev. 2011;(8):CD002201. PubMed
    5. 66354. Lawrence, R. and Sorrell, T. Eicosapentaenoic acid in cystic fibrosis: evidence of a pathogenetic role for leukotriene B4. Lancet 8-21-1993;342(8869):465-469. PubMed
  • An irregular heartbeat Worth acting on Additional detail

    “Orally and parenterally, fish oil is generally well-tolerated. Topically, no adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted.

    Most Common Adverse Effects:

    Orally: Abdominal pain, bad breath, fishy aftertaste, heartburn, increased low-density lipoprotein (LDL) cholesterol levels, loose stools, nausea, and rash.

    Serious Adverse Effects (Rare):

    Orally: Atrial…”

    Fish Oil · Natural Medicines adverse-effect record, reported in atrial fibrillation.

  • Anemia Worth acting on Additional detail

    “Orally, 3 grams or greater of omega-3 fatty acids daily may inhibit platelet aggregation and increase the risk of bleeding; however, there is little evidence of statistically significant bleeding risk at lower doses.”

    Fish Oil · Natural Medicines adverse-effect record, reported in anemia.

    6 sources cited
    1. 1313. FDA. Center for Food Safety and Applied Nutrition. Letter regarding dietary supplement health claim for omega-3 fatty acids and coronary heart disease. Available at: http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-Rpt0272-38-Appendix-D-Reference
    2. 8699. Pedersen HS, Mulvad G, Seidelin KN, et al. N-3 fatty acids as a risk factor for haemorrhagic stroke. Lancet 1999;353:812-3. PubMed
    3. 66500. Knapp, H. R. Dietary fatty acids in human thrombosis and hemostasis. Am J Clin Nutr 1997;65(5 Suppl):1687S-1698S. PubMed
    4. 66501. Archer, S. L., Green, D., Chamberlain, M., Dyer, A. R., and Liu, K. Association of dietary fish and n-3 fatty acid intake with hemostatic factors in the coronary artery risk development in young adults (CARDIA) study. Arterioscler Thromb.Vasc.Biol 1998;1 PubMed
    5. 66334. Weksler, B. B. Omega 3 fatty acids have multiple antithrombotic effects. World Rev Nutr Diet 1994;76:47-50. PubMed
    6. 101543. McNamara RK, Strawn JR, Tallman MJ, et al. Effects of fish oil monotherapy on depression and prefrontal neurochemistry in adolescents at high risk for bipolar I disorder: A 12-week placebo-controlled proton magnetic resonance spectroscopy trial. J Child A PubMed
  • A severe allergic reaction Worth acting on Additional detail

    “A case of anaphylaxis following ingestion of a fish oil capsule has been reported for a female patient with a history of allergy to crab. The patient was treated successfully with epinephrine, but had several recurrences of stridor over the next 2 days.

    There is also some evidence that fish oil in doses greater than 3 grams per day might adversely affect immune function.”

    Fish Oil · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    4 sources cited
    1. 89378. Kmet A, Unger J, Jahangir K, Kolber MR. Fish-oil capsule ingestion: a case of recurrent anaphylaxis. Can Fam Physician 2012;58(7):e379-81.
    2. 1313. FDA. Center for Food Safety and Applied Nutrition. Letter regarding dietary supplement health claim for omega-3 fatty acids and coronary heart disease. Available at: http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-Rpt0272-38-Appendix-D-Reference
    3. 7383. Kelley DS, Rudolph IL. Effect of individual fatty acids of omega-6 and omega-3 type on human immune status and role of eicosanoids. Nutrition 2000;16:143-5.
    4. 7384. Meydani SN, Dinarello CA. Influence of dietary fatty acids on cytokine production and its clinical implications. Nutr Clin Pract 1993;8:65-72. PubMed
  • Bleeding or bruising Worth acting on Additional detail

    Recorded for Fish Oil in the same Natural Medicines adverse-effect record shown under An irregular heartbeat above.

  • A higher chance of infection Worth acting on Additional detail

    Recorded for Fish Oil in the same Natural Medicines adverse-effect record shown under A severe allergic reaction above.

  • Heartburn Additional detail

    “Orally, most adverse effects of omega-3 fatty acids are gastrointestinal in nature. Gastrointestinal upset is common with the use of fish oil supplements, occurring in up to 5% of patients in clinical trials, with nausea in up to 1.5% of patients. Diarrhea and loose stools may also occur, with potentially severe diarrhea at very high doses.”

    Fish Oil · Natural Medicines adverse-effect record, reported in anorexia.

    6 sources cited
    1. 12915. Wang C, Chung M, Lichtenstein A, et al. Effects of omega-3 fatty acids on cardiovascular disease. Evid Rep Technol Assess (Summ) 2004 Mar;(94):1-8.
    2. 65599. Maclean, C. H., Mojica, W. A., Morton, S. C., Pencharz, J., Hasenfeld, Garland R., Tu, W., Newberry, S. J., Jungvig, L. K., Grossman, J., Khanna, P., Rhodes, S., and Shekelle, P. Effects of omega-3 fatty acids on lipids and glycemic control in type II di
    3. 65728. Reisman, J., Schachter, H. M., Dales, R. E., Tran, K., Kourad, K., Barnes, D., Sampson, M., Morrison, A., Gaboury, I., and Blackman, J. Treating asthma with omega-3 fatty acids: where is the evidence? A systematic review. BMC.Complement Altern Med 2006;6 PubMed
    4. 65770. Lim, A. K., Manley, K. J., Roberts, M. A., and Fraenkel, M. B. Fish oil for kidney transplant recipients. Cochrane Database Syst Rev 2007;(2):CD005282. DOI
    5. 65780. Freund-Levi, Y., Basun, H., Cederholm, T., Faxen-Irving, G., Garlind, A., Grut, M., Vedin, I., Palmblad, J., Wahlund, L. O., and Eriksdotter-Jonhagen, M. Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptom
    6. 65904. Turnbull, T., Cullen-Drill, M., and Smaldone, A. Efficacy of omega-3 fatty acid supplementation on improvement of bipolar symptoms: a systematic review. Arch Psychiatr.Nurs 2008;22(5):305-311. PubMed
  • A change in taste Additional detail

    Recorded for Fish Oil in the same Natural Medicines adverse-effect record shown under Heartburn above.

  • Weight gain Additional detail

    “Fish oil can contribute to caloric intake and may cause weight gain if used long-term. One gram of fat or oil provides 9 kcal. Fish oil capsules containing 500 mg omega-3 fatty acids in 1 gram of oil would supply about 13.5 kcal per capsule. Fish oil supplements also contain cholesterol in amounts from 1-6 mg per gram of fish oil.”

    Fish Oil · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    3 sources cited
    1. 6871. Mahan LK, Escott-Stump S. Krause's Food, Nutrition, and Diet Therapy. 9th edition. W.B. Saunders Co., Philadelphia, PA, 1996.
    2. 6874. Yetiv JZ. Clinical applications of fish oils. JAMA 1988;260:665-70. DOI
    3. 3022. Kastrup EK. Drug Facts and Comparisons. 1998 ed. St. Louis, MO: Facts and Comparisons, 1998.

Showing the 10 most notable of 23 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Fish Oil — expand a row for the licensed statement it rests on. We haven’t matched Guaifenesin, Hydrocodone to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Guaifenesin, Hydrocodone.

Special populations

Fish Oil in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally and appropriately. Intake of fish oil during pregnancy does not appear to adversely affect the fetus or nursing infant. One large clinical trial shows that intake of fish oil from the 24th week of gestation increases the odds of the child having overweight and having metabolic syndrome measurements at age 10 when compared with placebo. More research is needed to confirm these findings. The adequate intake level of omega-3 fatty acids during pregnancy is 1.4 grams daily; the adequate intake level during lactation is 1.3 grams daily. If possible, people who are trying to become pregnant, as well as those who are pregnant or lactating, should avoid swordfish, king mackerel, and tilefish (also called golden bass or golden snapper), as these may contain high levels of methylmercury. Pregnant individuals should also limit consumption of other fatty fish to 12 ounces, or about 3-4 servings, per week.

Pregnancy And Lactation Possibly Unsafe

When fish oil from dietary sources are consumed in large amounts. Fatty fish can contain significant amounts of toxins such as mercury, polychlorinated biphenyls (PCBs), dioxin, and dioxin-related compounds. If possible, people who are trying to become pregnant, as well as those who are pregnant or lactating, should avoid swordfish, king mackerel, and tilefish (also called golden bass or golden snapper), as these may contain high levels of methylmercury. Pregnant individuals should also limit consumption of other fatty fish to 12 ounces, or about 3-4 servings, per week.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Fish Oil or Guaifenesin, Hydrocodone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Fish Oil or Guaifenesin, Hydrocodone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Guaifenesin, Hydrocodone

This page covers Fish Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Guaifenesin, Hydrocodone page lists 212 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 164 moderate · 39 minor.

Open the Guaifenesin, Hydrocodone interaction page

One more smart check

Taking Fish Oil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,777 real supplement products containing Fish Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Fish Oil. Even though Fish Oil itself has no known interaction with Guaifenesin, Hydrocodone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Fish Oil and Guaifenesin, Hydrocodone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fish Oil
Top 5%

#58 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Guaifenesin, Hydrocodone
Top 25%

#321 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fish Oil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Fish Oil and Guaifenesin, Hydrocodone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fish Oil

What is Fish Oil?

Fish Oil
  • High triglycerides
  • Heart health
  • Joint pain and inflammation
  • Brain and eye health
  • Dry eyes

Fish oil provides omega-3 fatty acids (EPA and DHA) that are best known for lowering high triglyceride levels. The evidence for other heart and health benefits is mixed, and it is generally well tolerated. Talk with your pharmacist or doctor before starting it, especially if you take blood thinners or have a fish allergy.

Oil from fatty fish (such as mackerel, salmon, sardines, and anchovies) · Softgel capsules, liquid, gummies, and fortified foods

An interaction check asks whether these two react with each other — it does not ask whether Fish Oil is a good idea for someone in your situation. Here is what our Fish Oil record says about it on its own.

Fish Oil: dosing

There is no single standard dose of fish oil for everyone, and the right amount depends on why it is being used and the EPA/DHA content of the product. Higher, prescription-strength doses used for very high triglycerides should only be used under a doctor's supervision.

From our Fish Oil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fish Oil monograph & all interactions
Keep checking

Other Drugs & Fish Oil

Browse every other medication we’ve checked against Fish Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
207Moderate
120Minor
2,502No known interaction
207 Moderate 120 Minor 2,502 No interaction
Moderate

207 interactions

Showing 60 of 207 moderate interactions — see all 207 on the Fish Oil page.

Minor

120 interactions

Showing 60 of 120 minor interactions — see all 120 on the Fish Oil page.

No interaction 2,502 drugs checked — show the list

We also checked Fish Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,502 medications checked with no known interaction — see the full Fish Oil list.

See the full Fish Oil interactions page
See every supplement checked against Guaifenesin, Hydrocodone, ranked by severity
Evidence & sources

Fish Oil References

The 157 references that drive our Fish Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Prisco D, Paniccia R, Bandinelli B, et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Thromb Res 1998;1:105-12.
  2. Allard JP, Kurian R, Aghdassi E, Muggli R, et al. Lipid peroxidation during n-3 fatty acid and vitamin E supplementation in humans. Lipids 1997;32:535-41.. PubMed
  3. Toft I, Bonaa KH, Ingebretsen OC, et al. Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. Ann Intern Med 1995;123:911-8.
  4. Onwude JL, Lilford RJ, Hjartardottir H, et al. A randomised double blind placebo controlled trial of fish oil in high risk pregnancy. Br J Obstet Gynaecol 1995;102:95-100. PubMed
  5. Bulstra-Ramakers MT, Huisjes HJ, Visser GH. The effects of 3g eicosapentaenoic acid daily on recurrence of intrauterine growth retardation and pregnancy induced hypertension. Br J Obstet Gynaecol 1995;102:123-6. PubMed
  6. Sacks FM, Hebert P, Appel LJ, et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the trials of hypertension prevention. J Hypertens 1994;12:209-13.
  7. Vandongen R, Mori TA, Burke V, et al. Effects on blood pressure of omega 3 fats in subjects at increased risk of cardiovascular disease. Hypertension 1993;22:371-9. PubMed
  8. Hawthorne AB, Daneshmend TK, Hawkey CJ, et al. Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. Gut 1992;33:922-8. PubMed
  9. D'Almeida A, Carter JP, Anatol A, Prost C. Effects of a combination of evening primrose oil (gamma linolenic acid) and fish oil (eicosapentaenoic + docahexaenoic acid) versus magnesium, and versus placebo in preventing pre-eclampsia. Women Health 1992;19 PubMed
  10. FDA. Center for Food Safety and Applied Nutrition. Letter regarding dietary supplement health claim for omega-3 fatty acids and coronary heart disease. Available at: http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-Rpt0272-38-Appendix-D-Reference
  11. Montori VM, Farmer A, Wollan PC, Dinneen SF. Fish oil supplementation in type 2 diabetes: a quantitative systemic review (abstract). Diabetes Care 2000;23:1407-15.
  12. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
  13. Adler A, Holub BJ. Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men. Am J Clin Nutr 1997;65:445-50. PubMed
  14. Higdon JV, Liu J, Du S, et al. Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as asses
  15. Kastrup EK. Drug Facts and Comparisons. 1998 ed. St. Louis, MO: Facts and Comparisons, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fish Oil and Guaifenesin, Hydrocodone Together: Common Questions

Is it safe to take Fish Oil with Guaifenesin, Hydrocodone?
We do not list a known interaction between Fish Oil and Guaifenesin, Hydrocodone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Fish Oil and Guaifenesin, Hydrocodone combination checked?
Interactions in our licensed database are recorded against drug classes. Guaifenesin, Hydrocodone is filed under 6 classifications, and Fish Oil has documented interactions with 9 drug classes — none of Guaifenesin, Hydrocodone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Fish Oil interact with any other medications?
Yes. Fish Oil has 327 documented drug interactions in our database — Guaifenesin, Hydrocodone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Guaifenesin, Hydrocodone interact with any supplements?
Yes. Guaifenesin, Hydrocodone has documented interactions with 212 supplements in our database — Fish Oil is not one of them. The Guaifenesin, Hydrocodone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fish Oil monograph Uses, safety profile, and every drug interaction in one place Guaifenesin, Hydrocodone supplement interactions Every supplement checked against Guaifenesin, Hydrocodone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 157 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Guaifenesin, Hydrocodone and Fish Oil?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.