Drug & supplement interaction

Globemallow + Nabumetone

Nabumetone brand names: Relafen, Nabumetone.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Globemallow and Nabumetone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Globemallow and Nabumetone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Nabumetone and Globemallow in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Globemallow at all — not against Nabumetone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Globemallow safety at a glance

Globemallow overall Not established Little modern safety data exists, so use cautiously and under professional guidance.
Pregnancy Avoid There is no reliable safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety during breastfeeding is unknown, so avoid use to be safe.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Nabumetone and Globemallow? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Nabumetone’s Own FDA Label Lists

This is not an interaction — none of it involves Globemallow. These are the most notable effects listed in the ADVERSE REACTIONS section of Nabumetone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Pain or burning when passing urine Worth acting on
  • Trouble swallowing Worth acting on
  • Bleeding in the gut Worth acting on
  • Low potassium Worth acting on
  • A heart attack Worth acting on
  • Blood clots Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • High blood sugar Worth acting on
  • Fainting Worth acting on

Showing the 10 most notable of 64 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Nabumetone. Read the label on DailyMed › Where a percentage is shown, it is the share of 6,395 voluntary FDA FAERS reports for Nabumetone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Globemallow’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Globemallow side to compare — that is a limit of the record, not a statement that Globemallow has no side effects.

Overlapping uses

What Nabumetone Is Prescribed For, and What Globemallow Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Nabumetone is a prescription medicine with approved uses on its FDA label. Globemallow is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Nabumetone is prescribed for: Nabumetone tablets — available as generic nabumetone and as the brand Relafen DS — are used to relieve pain, swelling, and stiffness caused by osteoarthritis and rheumatoid arthritis. It is meant to be used at the lowest effective dose for the shortest time needed. It is not approved for pain relief around coronary artery bypass graft (CABG) heart surgery.

Globemallow has been studied for:

  • Osteoarthritis studied, not established Globemallow has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Globemallow for osteoarthritis

    It is unclear if topical globemallow is beneficial in patients with osteoarthritis.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Nabumetone on your own; if you are taking Globemallow for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Globemallow or Nabumetone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Globemallow or Nabumetone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Nabumetone

This page covers Globemallow only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Nabumetone page lists 52 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 35 moderate · 12 minor.

From our pharmacist’s overview on the Nabumetone page

“Five of the 52 supplement and herbal ingredients on file for nabumetone (Relafen) rate major, and those five are where real vigilance belongs. Nabumetone is an NSAID taken for arthritis and joint pain, and NSAIDs already stress the stomach and the kidneys, so the worst pairings hit exactly those weak spots.”

Reviewed by 2 · Jul 18, 2026

Open the Nabumetone interaction page

How much people look this up

Where Globemallow and Nabumetone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Globemallow
Steady interest

#776 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Nabumetone
Steady interest

#2,765 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Globemallow is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Globemallow reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Globemallow and Nabumetone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Globemallow

What is Globemallow?

  • Soothing skin irritation
  • Cough and sore throat
  • Digestive upset
  • Minor wounds and inflammation
  • Mouth and throat soothing

Globemallow refers to plants in the genus Sphaeralcea, which have a long history of traditional use among Indigenous peoples of the Americas, mainly as a soothing remedy for skin, throat, and digestive complaints. There is very little modern scientific research on its safety or effectiveness, so its benefits remain unproven. Talk to your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.

Sphaeralcea · Malvaceae · Leaves, flowers, roots, and whole aerial parts · Tea, poultice, dried herb, infusion

An interaction check asks whether these two react with each other — it does not ask whether Globemallow is a good idea for someone in your situation. Here is what our Globemallow record says about it on its own.

Globemallow: dosing

There is no established or standardized dose for globemallow. It has not been studied enough to set safe, effective amounts for any use.If you choose to use a globemallow product, follow the directions on the product label and do not exceed them.

From our Globemallow monograph — the full record covers uses, side effects and every documented interaction.

Read the full Globemallow monograph & all interactions
Medication

About Nabumetone

What Is Nabumetone Used For?

Brand names: Relafen, Nabumetone

Nabumetone tablets — available as generic nabumetone and as the brand Relafen DS — are used to relieve pain, swelling, and stiffness caused by osteoarthritis and rheumatoid arthritis.

It is meant to be used at the lowest effective dose for the shortest time needed. It is not approved for pain relief around coronary artery bypass graft (CABG) heart surgery.

Most-Reported Side Effects for Nabumetone

From FAERS, the FDA’s public side-effect reporting system (6,395 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 376 reports
Fatigue 363 reports
Headache 319 reports
Arthralgia 312 reports
Dyspnea 245 reports
See full Nabumetone drug information
Keep checking

Other Drugs & Globemallow

Browse every other medication we’ve checked against Globemallow — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Globemallow against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Globemallow list.

See the full Globemallow interactions page
See every supplement checked against Nabumetone, ranked by severity
Evidence & sources

Globemallow References

The 2 sources that drive our Globemallow monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Globemallow is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source
  2. Herbal Supplements — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Globemallow and Nabumetone Together: Common Questions

Is it safe to take Globemallow with Nabumetone?
We do not list a known interaction between Globemallow and Nabumetone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Globemallow and Nabumetone used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Globemallow in each. That is a conversation for your prescriber, especially if Nabumetone is being adjusted to a target.
Does Nabumetone interact with any supplements?
Yes. Nabumetone has documented interactions with 52 supplements in our database — Globemallow is not one of them. The Nabumetone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Globemallow monograph Uses, safety profile, and every drug interaction in one place Nabumetone drug information The full plain-English guide to this medication Nabumetone supplement interactions Every supplement checked against Nabumetone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Nabumetone and Globemallow?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.