Drug & supplement interaction

Goldthread + Opicapone

Opicapone brand name: Ongentys.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Goldthread and Opicapone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Goldthread and Opicapone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Opicapone and Goldthread in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Goldthread safety at a glance

Goldthread overall Use caution May be tolerated short-term by some adults, but human safety data are limited and quality varies between products.
Pregnancy Likely Unsafe When used orally. Berberine is thought to cross the placenta and may cause harm to the fetus. Kernicterus has developed in newborn infants exposed to berberine.... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Berberine and other harmful constituents can be transferred to the infant through breast milk. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Opicapone and Goldthread? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Opicapone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Opicapone is filed under 3 classifications — dopamine agonists, p-glycoprotein substrates, oral drugs. Goldthread has documented interactions with 2 drug classes — the most serious being cyclosporine (neoral, sandimmune) (moderate) and cytochrome p450 3a4 (cyp3a4) substrates (moderate) — and none of Opicapone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Goldthread Does Interact With Other Medications

Goldthread has 643 moderate known drug interactions in our database — Opicapone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 643 No known interaction 2,187 (incl. Opicapone)
Taking anything else?

Check Another of Your Medications Against Goldthread

Covers the 2,830 medications we’ve checked against Goldthread. Pick one to open its full report.

What to actually watch for

What Opicapone’s Own FDA Label Lists

This is not an interaction — none of it involves Goldthread. These are the most notable effects listed in the ADVERSE REACTIONS section of Opicapone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 4 of them are worth acting on rather than waiting out — marked below.

  • Hallucinations Worth acting on mentioned in 13.9% of FDA reports for Opicapone
  • Fainting Worth acting on
  • Confusion Worth acting on
  • Raised blood pressure Worth acting on
  • Weight gain
  • Weight loss
  • Dry mouth
  • Low blood pressure
  • Drowsiness
  • Trouble sleeping

Showing the 10 most notable of 12 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Opicapone. Read the label on DailyMed › Where a percentage is shown, it is the share of 2,261 voluntary FDA FAERS reports for Opicapone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Goldthread’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Goldthread side to compare — that is a limit of the record, not a statement that Goldthread has no side effects.

Special populations

Goldthread in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Berberine is thought to cross the placenta and may cause harm to the fetus. Kernicterus has developed in newborn infants exposed to berberine. Preliminary evidence suggests that maternal intake of goldthread during the first trimester increases the risk of congenital malformations of the central nervous system.

Lactation Likely Unsafe

When used orally. Berberine and other harmful constituents can be transferred to the infant through breast milk.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Opicapone

This page covers Goldthread only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Opicapone page lists 58 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Ayahuasca (moderate), Bitter Melon (moderate) and Black Horehound (moderate).

By severity: 2 major · 39 moderate · 17 minor.

From our pharmacist’s overview on the Opicapone page

“If you take opicapone (Ongentys) alongside levodopa for Parkinson's disease, don't skim this page. Two entries can genuinely undercut your treatment: St.”

Reviewed by 2 · Jul 18, 2026

Open the Opicapone interaction page

One more smart check

Taking Goldthread as Part of a Dietary Supplement Product? Check It for Interactions

We hold 25 real supplement products containing Goldthread, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Goldthread. Even though Goldthread itself has no known interaction with Opicapone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Goldthread and Opicapone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Goldthread
Top 25%

#293 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Opicapone
Top 25%

#663 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Goldthread reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Goldthread and Opicapone records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Goldthread

What is Goldthread?

Goldthread
  • Digestive upset and diarrhea
  • Mouth sores and sore throat
  • Inflammation
  • Antimicrobial (fighting germs)
  • Blood sugar support
  • Skin and eye complaints

Goldthread is a traditional Chinese and East Asian herb whose root is rich in berberine, a compound being studied for blood sugar, cholesterol, and antimicrobial effects. Strong human evidence for goldthread itself is limited, and it should be avoided in pregnancy and breastfeeding. Talk with your pharmacist or doctor before using it, especially if you take other medicines.

Coptis chinensis · Ranunculaceae · Root and rhizome (the underground stem) · Dried root, powder, capsules, tinctures, teas, and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Goldthread is a good idea for someone in your situation. Here is what our Goldthread record says about it on its own.

Goldthread: dosing

There is no well-established standard dose for goldthread. Products differ widely in how they are made and how much active compound they contain, so it is hard to recommend a single safe amount.The best approach is to follow the directions on the product label and not exceed them.

From our Goldthread monograph — the full record covers uses, side effects and every documented interaction.

Read the full Goldthread monograph & all interactions
Medication

About Opicapone

What Is Opicapone Used For?

Brand name: Ongentys

Ongentys (opicapone) is used alongside levodopa/carbidopa to treat Parkinson's disease in adults who experience 'off' episodes — periods when medication wears off and Parkinson's symptoms return before the next dose is due.

It is not used alone. Ongentys works as an add-on to help levodopa stay active longer, reducing the time patients spend in these 'off' states.

Most-Reported Side Effects for Opicapone

From FAERS, the FDA’s public side-effect reporting system (2,261 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hallucination 314 reports
Dyskinesia 306 reports
Fall 258 reports
On and off phenomenon 158 reports
Tremor 143 reports
See full Opicapone drug information
Keep checking

Other Drugs & Goldthread

Browse every other medication we’ve checked against Goldthread — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
643Moderate
0Minor
2,186No known interaction
643 Moderate 2,186 No interaction
Moderate

643 interactions

Showing 60 of 643 moderate interactions — see all 643 on the Goldthread page.

No interaction 2,186 drugs checked — show the list

We also checked Goldthread against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,186 medications checked with no known interaction — see the full Goldthread list.

See the full Goldthread interactions page
See every supplement checked against Opicapone, ranked by severity
Evidence & sources

Goldthread References

The 3 references that drive our Goldthread monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
  2. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
  3. Chuang CH, Doyle P, Wang JD, et al. Herbal medicines used during the first trimester and major congenital malformations: an analysis of data from a pregnancy cohort study. Drug Saf 2006;29:537-48. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Goldthread and Opicapone Together: Common Questions

Is it safe to take Goldthread with Opicapone?
We do not list a known interaction between Goldthread and Opicapone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Goldthread and Opicapone combination checked?
Interactions in our licensed database are recorded against drug classes. Opicapone is filed under 3 classifications, and Goldthread has documented interactions with 2 drug classes — none of Opicapone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Goldthread interact with any other medications?
Yes. Goldthread has 643 documented drug interactions in our database — Opicapone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Opicapone interact with any supplements?
Yes. Opicapone has documented interactions with 58 supplements in our database — Goldthread is not one of them. The Opicapone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Goldthread monograph Uses, safety profile, and every drug interaction in one place Opicapone drug information The full plain-English guide to this medication Opicapone supplement interactions Every supplement checked against Opicapone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Opicapone and Goldthread?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.