Drug & supplement interaction

Guggul + Rosuvastatin Calcium, Ezetimibe

Rosuvastatin Calcium, Ezetimibe brand name: Roszet.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Guggul has a moderate interaction with Rosuvastatin Calcium, Ezetimibe. Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Guggul and Rosuvastatin Calcium, Ezetimibe

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ROSUVASTATIN (Crestor)

Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.
Animal research shows that guggul increases the bioavailability and hypolipidemic effects of rosuvastatin. The mechanism of this interaction is unclear.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Roszet combines two cholesterol medicines: rosuvastatin (a statin) and ezetimibe. The thing to know here is about the rosuvastatin part. Animal studies hint that guggul may raise the amount of rosuvastatin your body absorbs, which could make its effects stronger than expected. I want to be honest with you, though: this is only based on lab and animal research, not human studies, so it's more of a theoretical flag than a proven problem.

If rosuvastatin levels do climb, the usual concerns would be muscle aches, weakness, or rarely more serious muscle issues. It's worth a quick chat with your pharmacist or doctor before adding guggul, so they can decide if it's right for you. Please don't stop or change anything on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Asad M, Asdaq SMB, Mohzari Y, et al. Pharmacokinetic and pharmacodynamic interaction of Rosuvastatin calcium with guggulipid extract in rats. Saudi J Biol Sci 2021;28(6):3490-3496. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Guggul Also Interacts With Other Medications

Guggul has 756 moderate known drug interactions in our database — the Rosuvastatin Calcium, Ezetimibe one above is one of them. If you take anything else, check it against the full list below.

Moderate 756 No known interaction 2,074 (incl. Rosuvastatin Calcium, Ezetimibe)
Taking anything else?

Check Another of Your Medications Against Guggul

Covers the 2,830 medications we’ve checked against Guggul. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Rosuvastatin Calcium, Ezetimibe

This page covers Guggul only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Rosuvastatin Calcium, Ezetimibe page lists 64 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 49 moderate · 10 minor.

From our pharmacist’s overview on the Rosuvastatin Calcium, Ezetimibe page

“The person most likely taking Roszet (rosuvastatin plus ezetimibe) is often the same person browsing the supplement aisle for anything heart-healthy, and that overlap deserves genuine caution. Five of the 64 interactions on file are rated major, including grapefruit, which can push statin blood levels up, and alcohol, which strains a l…”

Reviewed by 2 · Jul 18, 2026

Open the Rosuvastatin Calcium, Ezetimibe interaction page

One more smart check

Taking Guggul as Part of a Dietary Supplement Product? Check It for Interactions

We hold 955 real supplement products containing Guggul, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Guggul. Your product may carry other ingredients that interact with Rosuvastatin Calcium, Ezetimibe too, on top of Guggul — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Guggul and Rosuvastatin Calcium, Ezetimibe Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Guggul
Top 25%

#190 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Rosuvastatin Calcium, Ezetimibe
Top 25%

#325 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Guggul

What is Guggul?

Guggul
  • High cholesterol
  • Joint pain and arthritis
  • Weight management
  • Acne
  • Skin conditions

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are mixed and often low-quality, and it can cause stomach upset and skin rashes. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Read the full Guggul monograph & all interactions
Keep checking

Other Drugs & Guggul

Browse every other medication we’ve checked against Guggul — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
756Moderate
0Minor
2,073No known interaction
756 Moderate 2,073 No interaction
Moderate

756 interactions

Showing 60 of 756 moderate interactions — see all 756 on the Guggul page.

No interaction 2,073 drugs checked — show the list

We also checked Guggul against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,073 medications checked with no known interaction — see the full Guggul list.

See the full Guggul interactions page
See every supplement checked against Rosuvastatin Calcium, Ezetimibe, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Guggul monograph › Uses, safety, and every drug interaction in one place Rosuvastatin Calcium, Ezetimibe supplement interactions › Every supplement checked against Rosuvastatin Calcium, Ezetimibe, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Guggul and Rosuvastatin Calcium, Ezetimibe Together: Common Questions

Can you take Guggul with Rosuvastatin Calcium, Ezetimibe?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Guggul and Rosuvastatin Calcium, Ezetimibe interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Rosuvastatin Calcium, Ezetimibe and Guggul?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.