Medication interaction hub

What Supplements Interact with Rosuvastatin Calcium, Ezetimibe?

Rosuvastatin Calcium, Ezetimibe brand name: Roszet. Every interaction below applies to the brands too.

64 Interactions 5 Major 49 Moderate 10 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Rosuvastatin Calcium, Ezetimibe? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Rosuvastatin Calcium, Ezetimibe against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

The person most likely taking Roszet (rosuvastatin plus ezetimibe) is often the same person browsing the supplement aisle for anything heart-healthy, and that overlap deserves genuine caution. Five of the 64 interactions on file are rated major, including grapefruit, which can push statin blood levels up, and alcohol, which strains a liver already processing this medication. Liver stress is the dominant theme, with 38 of these ingredients carrying potential for liver harm on top of the drug's own.

Red yeast rice deserves special mention because it contains a natural statin, so pairing it with Roszet stacks two of the same drug. Another 17 entries, charcoal products and thick fibers among them, can reduce how much of the tablet you absorb, so keep those well separated from your dose. The remaining 49 moderate and 10 minor entries are worth a look too, starting with whatever is already in your cabinet.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 49 Minor 10 No known interaction 1,388

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Rosuvastatin Calcium, Ezetimibe: Top Interactions at a Glance

The most significant Rosuvastatin Calcium, Ezetimibe supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 64 interacting ingredients — plus 1,388 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Rosuvastatin Calcium, Ezetimibe + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Rosuvastatin Calcium, Ezetimibei

Grapefruit juice can increase blood levels of statins that are metabolized by cytochrome P450 3A4 (CYP3A4), potentially increasing the effects and adverse effec...

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Rosuvastatin Calcium, Ezetimibei

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Probable Activated Charcoal + Rosuvastatin Calcium, Ezetimibei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Rosuvastatin Calcium, Ezetimibei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable Wine + Rosuvastatin Calcium, Ezetimibei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Rosuvastatin Calcium, Ezetimibe

All 1,452 ingredients in our database, ranked by severity — 64 with a Rosuvastatin Calcium, Ezetimibe interaction on file and 1,388 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Rosuvastatin Calcium, Ezetimibe?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Grapefruit with Rosuvastatin Calcium, Ezetimibe?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase blood levels of statins that are metabolized by cytochrome P450 3A4 (CYP3A4), potentially increasing the effec...

Full Grapefruit + Rosuvastatin Calcium, Ezetimibe answer

Can you take Turmeric with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Turmeric + Rosuvastatin Calcium, Ezetimibe answer

Can you take Chaparral with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Chaparral + Rosuvastatin Calcium, Ezetimibe answer

Can you take Manchurian Thorn with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that high doses of Manchurian thorn can induce liver damage.

Full Manchurian Thorn + Rosuvastatin Calcium, Ezetimibe answer

Can you take Niacin with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Full Niacin + Rosuvastatin Calcium, Ezetimibe answer

Can you take Noni with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.

Full Noni + Rosuvastatin Calcium, Ezetimibe answer

Can you take Ostarine with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.

Full Ostarine + Rosuvastatin Calcium, Ezetimibe answer

Can you take Padang Cassia with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that ingesting large amounts of Padang cassia might cause hepatotoxicity in some people.

Full Padang Cassia + Rosuvastatin Calcium, Ezetimibe answer

Can you take Pomegranate with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.

Full Pomegranate + Rosuvastatin Calcium, Ezetimibe answer

Can you take Rhubarb with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.

Full Rhubarb + Rosuvastatin Calcium, Ezetimibe answer

Can you take Saigon Cinnamon with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Saigon Cinnamon + Rosuvastatin Calcium, Ezetimibe answer

Can you take Slippery Elm with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Rosuvastatin Calcium, Ezetimibe answer

Can you take Spearmint with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Spearmint + Rosuvastatin Calcium, Ezetimibe answer

Can you take Sweet Annie with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Sweet Annie + Rosuvastatin Calcium, Ezetimibe answer

Can you take Sweet Clover with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.

Full Sweet Clover + Rosuvastatin Calcium, Ezetimibe answer

Can you take Syrian Rue with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of Syrian rue might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Syrian Rue + Rosuvastatin Calcium, Ezetimibe answer

Can you take Testolone with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Testolone + Rosuvastatin Calcium, Ezetimibe answer

Can you take Tragacanth with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Rosuvastatin Calcium, Ezetimibe answer

Can you take Vitamin A with Rosuvastatin Calcium, Ezetimibe?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disea...

Full Vitamin A + Rosuvastatin Calcium, Ezetimibe answer

Can you take Thyroid Extract with Rosuvastatin Calcium, Ezetimibe?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Rosuvastatin Calcium, Ezetimibe answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Rosuvastatin Calcium, Ezetimibe is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Rosuvastatin Calcium, Ezetimibe, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Rosuvastatin Calcium, Ezetimibe sits in 5 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Rosuvastatin Calcium, Ezetimibe through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Rosuvastatin Calcium, Ezetimibe through this category.

Hmg-Coa Reductase Inhibitors ("Statins") 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Rosuvastatin Calcium, Ezetimibe through this category.

Rosuvastatin (Crestor) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Rosuvastatin Calcium, Ezetimibe through this category.

Ezetimibe (Zetia) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Rosuvastatin Calcium, Ezetimibe through this category.

Related: does Rosuvastatin Calcium, Ezetimibe deplete any nutrients?

Rosuvastatin Calcium, Ezetimibe has 1 reported nutrient association in the research literature — see the Rosuvastatin Calcium, Ezetimibe nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Rosuvastatin Calcium, Ezetimibe

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Rosuvastatin Calcium, Ezetimibe.

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Pharmacist Counseling Corner

Rosuvastatin Calcium, Ezetimibe & Supplements: Common Questions

What supplements interact with Rosuvastatin Calcium, Ezetimibe?
In our interaction database, 64 supplement and herbal ingredients have an interaction with Rosuvastatin Calcium, Ezetimibe on file — 5 rated major, 49 moderate, and 10 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Rosuvastatin Calcium, Ezetimibe supplement interactions are the most serious?
Focus on the major group: Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and Wine. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Rosuvastatin Calcium, Ezetimibe?
That depends entirely on which supplement. The honest answer for Rosuvastatin Calcium, Ezetimibe is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Roszet have the same supplement interactions as Rosuvastatin Calcium, Ezetimibe?
Yes — Roszet all contain Rosuvastatin Calcium, Ezetimibe, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Rosuvastatin Calcium, Ezetimibe deplete any vitamins or nutrients?
It might — Rosuvastatin Calcium, Ezetimibe has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Rosuvastatin Calcium, Ezetimibe nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Rosuvastatin Calcium, Ezetimibe and my other medications?
This page covers Rosuvastatin Calcium, Ezetimibe against supplements and herbal ingredients. Checking Rosuvastatin Calcium, Ezetimibe against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.