Hercules Club + Pentobarbitone
Pentobarbitone brand name: Pentobarbitone.
We found no known interaction between Hercules Club and Pentobarbitone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Hercules Club and Pentobarbitone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Pentobarbitone and Hercules Club in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Hercules Club safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Pentobarbitone
Interactions in our licensed database are recorded against drug classes, not just single drug names. Pentobarbitone is filed under 5 classifications — including barbiturates, anticonvulsants, cns depressants. Hercules Club has documented interactions with 3 drug classes — the most serious being antacids (minor), h2-blockers (minor) and proton pump inhibitors (ppis) (minor) — and none of Pentobarbitone’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Hercules Club Does Interact With Other Medications
Hercules Club has 36 minor known drug interactions in our database — Pentobarbitone isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Hercules Club
We haven’t checked that one against Hercules Club yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Hercules Club. Pick one to open its full report.
Hercules Club in Pregnancy & Breastfeeding
When used orally because it might have menstrual stimulant effects. There is insufficient reliable information available about the safety of the berry during pregnancy; avoid using.
When used orally because it might cause colic in nursing infants.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Pentobarbitone
This page covers Hercules Club only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pentobarbitone page lists 127 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).
By severity: 7 major · 103 moderate · 17 minor.
From our pharmacist’s overview on the Pentobarbitone page
“Pentobarbitone is a barbiturate, one of the older and heavier sedatives, and the gap between a dose that helps sleep and one that slows breathing too far is not a generous one. That is why I read this particular list with genuine concern.”
Reviewed by 2 · Jul 18, 2026
Where Hercules Club and Pentobarbitone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,416 of 1,452 supplements looked up here in the last 7 days
#1,340 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hercules Club reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Hercules Club and Pentobarbitone records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Hercules Club
What is Hercules Club?
- Toothache and mouth pain
- Indigestion and sluggish digestion
- Rheumatism and joint pain
- Circulation (as a stimulant or tonic)
- Sore throat
Hercules Club (southern prickly ash) is a traditional folk remedy used mainly for toothache, digestion, and joint pain, often by chewing the bark, which causes a tingling, numbing feeling in the mouth. Modern scientific evidence supporting these uses is very limited, and safety has not been well studied, so it is best to talk with a pharmacist or doctor before using it.
Zanthoxylum clava-herculis · Rutaceae · Bark, roots, and berries · Dried bark, tinctures, teas, and topical preparations
An interaction check asks whether these two react with each other — it does not ask whether Hercules Club is a good idea for someone in your situation. Here is what our Hercules Club record says about it on its own.
Hercules Club: dosing
There is no established standardized dose for Hercules Club. Traditional use varied widely, and product strengths differ from one brand to another.If you choose to use a commercial product, follow the directions on the label and do not exceed them.
From our Hercules Club monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Hercules Club
Browse every other medication we’ve checked against Hercules Club — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
36 interactions
- Ranitidine ›
- Calcium Carbonate ›
- Famotidine ›
- Aluminum Hydroxide ›
- Cimetidine ›
- Omeprazole ›
- Pantoprazole ›
- Magnesium Sulfate (prescription Drug) ›
- Nizatidine ›
- Rabeprazole Sodium ›
- Dexlansoprazole ›
- Dihydroxyaluminum Sodium Carbonate ›
- Esomeprazole ›
- Esomeprazole Magnesium ›
- Esomeprazole Strontium ›
- Lansoprazole ›
- Magaldrate ›
- Rabeprazole ›
- Ranitidine Bismuth Citrate ›
- Sodium Bicarbonate (otc Drug) ›
- Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) ›
- Alginic Acid, Aluminum Hydroxide ›
- Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide ›
- Aluminum Hydroxide, Aspirin, Magnesium Hydroxide ›
- Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) ›
- Aluminum, Magnesium (otc Drug) ›
- Amoxicillin, Omeprazole Magnesium, Rifabutin ›
- Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide ›
- Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide ›
- Aspirin, Citric Acid, Sodium Bicarbonate ›
- Aspirin, Omeprazole ›
- Bismuth Subcarbonate, Calcium Carbonate, Opium ›
- Esomeprazole, Naproxen ›
- Famotidine, Ibuprofen ›
- Lansoprazole, Amoxicillin, Clarithromycin ›
- Omeprazole, Sodium Bicarbonate ›
No interaction 2,793 drugs checked — show the list
We also checked Hercules Club against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Ibuprofen ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,793 medications checked with no known interaction — see the full Hercules Club list.
Hercules Club References
The 2 references that drive our Hercules Club monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Pentobarbitone Is Linked to Lower Levels of One Nutrient
Natural Medicines records Pentobarbitone as a medicine that can lower these. This is not an interaction with Hercules Club — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Pentobarbitone nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Hercules Club and Pentobarbitone Together: Common Questions
Is it safe to take Hercules Club with Pentobarbitone?
How was the Hercules Club and Pentobarbitone combination checked?
Does Hercules Club interact with any other medications?
Does Pentobarbitone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.