Drug & supplement interaction

Histidine + Verapamil

Verapamil brand names: Isoptin SR, Verelan, Isoptin, Calan SR, Verelan SR, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Histidine and Verapamil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Histidine and Verapamil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Verapamil and Histidine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Histidine at all — not against Verapamil, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Histidine safety at a glance

Histidine overall Use caution Likely safe in amounts found in food, but the safety of higher supplement doses is not well established.
Pregnancy Likely Safe When used orally in the amounts found in foods. There is insufficient reliable information available about the safety of histidine when used in larger amounts d... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in the amounts found in foods. There is insufficient reliable information available about the safety of histidine when used in larger amounts d... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Verapamil and Histidine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Verapamil’s Own FDA Label Lists

This is not an interaction — none of it involves Histidine. These are the most notable effects listed in the ADVERSE REACTIONS section of Verapamil’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • A bowel blockage Worth acting on
  • A slow heartbeat Worth acting on
  • Heart failure Worth acting on
  • Raised blood pressure Worth acting on
  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • A stuffy or runny nose
  • Sore throat
  • Low blood pressure
  • Stomach upset

Showing the 10 most notable of 17 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Verapamil. Read the label on DailyMed › Histidine’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Histidine side to compare — that is a limit of the record, not a statement that Histidine has no side effects.

Special populations

Histidine in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in the amounts found in foods. There is insufficient reliable information available about the safety of histidine when used in larger amounts during pregnancy or lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Verapamil Is Prescribed For, and What Histidine Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Verapamil is a prescription medicine with approved uses on its FDA label. Histidine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Verapamil is prescribed for: Verapamil tablets and film-coated tablets are used to treat angina — including vasospastic (Prinzmetal's) angina, unstable angina, and chronic stable angina — as well as certain abnormal heart rhythms (arrhythmias) and high blood pressure (essential hypertension). For arrhythmias, regular-release tablets are used alongside digoxin to control heart rate in atrial flutter or atrial fibrillation, and to help prevent episodes of paroxysmal supraventricular tachycardia (SVT), a type of rapid heartbeat. Extended-release and sustained-release oral forms (tablets and capsules) are indicated specifically for high blood pressure. Verapamil hydrochloride injection is used in hospital settings for rapid conversion of SVT to normal rhythm and for temporary control of fast heart rates in atrial flutter or atrial fibrillation.

Histidine has been studied for:

  • Kidney failure studied, not established Histidine has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Histidine for kidney failure

    It is unclear if oral L-histidine is beneficial for anemia in patients with kidney failure.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Verapamil on your own; if you are taking Histidine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Histidine or Verapamil

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Histidine or Verapamil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Verapamil

This page covers Histidine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Verapamil page lists 295 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Beer (major) and Coleus (major).

By severity: 10 major · 245 moderate · 40 minor.

From our pharmacist’s overview on the Verapamil page

“This is one of the longer interaction lists we publish, and with verapamil (Calan, Verelan) it warrants genuine care, starting with the ten major-rated entries. Verapamil lowers blood pressure and slows the heart, so most of the 295 ingredients on file either push that effect further than intended or change how much of the drug reaches…”

Reviewed by 2 · Jul 18, 2026

Open the Verapamil interaction page

One more smart check

Taking Histidine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,921 real supplement products containing Histidine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Histidine. Even though Histidine itself has no known interaction with Verapamil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Histidine and Verapamil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Histidine
Top 10%

#125 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Verapamil
Top 25%

#643 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Histidine is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Histidine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Histidine and Verapamil records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Histidine

What is Histidine?

  • Skin conditions like eczema
  • Anemia related to kidney disease
  • Allergy and inflammation support
  • General amino acid supplementation
  • Athletic and protein supplementation

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from a normal diet, and good-quality research supporting histidine supplements for specific health conditions is limited. If you are considering a supplement, talk with a pharmacist or doctor first.

Amino acid (typically made commercially through fermentation) · Capsules, tablets, powder, part of amino acid blends and protein supplements

An interaction check asks whether these two react with each other — it does not ask whether Histidine is a good idea for someone in your situation. Here is what our Histidine record says about it on its own.

Histidine: dosing

There is no well-established standard supplement dose of histidine for treating health conditions. Amounts used in research have varied widely depending on the purpose.If you choose to use a histidine product, follow the directions on the label and do not exceed the recommended amount.

From our Histidine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Histidine monograph & all interactions
Medication

About Verapamil

What Is Verapamil Used For?

Brand names: Isoptin SR, Verelan, Isoptin, Calan SR, Verelan SR, Calan, Covera HS, Verap, Veramil

Verapamil tablets and film-coated tablets are used to treat angina — including vasospastic (Prinzmetal's) angina, unstable angina, and chronic stable angina — as well as certain abnormal heart rhythms (arrhythmias) and high blood pressure (essential hypertension). For arrhythmias, regular-release tablets are used alongside digoxin to control heart rate in atrial flutter or atrial fibrillation, and to help prevent episodes of paroxysmal supraventricular tachycardia (SVT), a type of rapid heartbeat.

Extended-release and sustained-release oral forms (tablets and capsules) are indicated specifically for high blood pressure. Verapamil hydrochloride injection is used in hospital settings for rapid conversion of SVT to normal rhythm and for temporary control of fast heart rates in atrial flutter or atrial fibrillation.

Most-Reported Side Effects for Verapamil

From FAERS, the FDA’s public side-effect reporting system (4,297 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 352 reports
Nausea 351 reports
Dizziness 295 reports
Hypotension 293 reports
Fatigue 275 reports
See full Verapamil drug information
Keep checking

Other Drugs & Histidine

Browse every other medication we’ve checked against Histidine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Histidine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Histidine list.

See the full Histidine interactions page
See every supplement checked against Verapamil, ranked by severity
Evidence & sources

Histidine References

The 3 sources that drive our Histidine monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Histidine is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Histidine — MedlinePlus (U.S. National Library of Medicine) Source
  2. Amino Acids — MedlinePlus (U.S. National Library of Medicine) Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Histidine and Verapamil Together: Common Questions

Is it safe to take Histidine with Verapamil?
We do not list a known interaction between Histidine and Verapamil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Histidine and Verapamil used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Histidine in each. That is a conversation for your prescriber, especially if Verapamil is being adjusted to a target.
Does Verapamil interact with any supplements?
Yes. Verapamil has documented interactions with 295 supplements in our database — Histidine is not one of them. The Verapamil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Histidine monograph Uses, safety profile, and every drug interaction in one place Verapamil drug information The full plain-English guide to this medication Verapamil supplement interactions Every supplement checked against Verapamil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Verapamil and Histidine?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.