Drug & supplement interaction

Hound's Tongue + Interferon Beta-1b

Interferon Beta-1b brand names: Betaseron, Betaferon, Extavia.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Hound's Tongue and Interferon Beta-1b in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Hound's Tongue and Interferon Beta-1b

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Interferon Beta-1b and Hound's Tongue in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hound's Tongue safety at a glance

Hound's Tongue overall Avoid It contains liver-toxic pyrrolizidine alkaloids, so internal use is not recommended.
Pregnancy Likely Unsafe When used orally. Hound's tongue preparations containing pyrrolizidine alkaloid (PA) constituents might be teratogenic and hepatotoxic. There is insufficient re... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in hound's tongue are excreted in milk. There is insufficient reliable information availa... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Interferon Beta-1b and Hound's Tongue? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Interferon Beta-1b

Interactions in our licensed database are recorded against drug classes, not just single drug names. Interferon Beta-1b is filed under 2 classifications — photosensitizing drugs, hepatotoxic drugs. Hound's Tongue has documented interactions with 1 drug class — the most serious being cytochrome p450 3a4 (cyp3a4) inducers (moderate) — and none of Interferon Beta-1b’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Hound's Tongue Does Interact With Other Medications

Hound's Tongue has 87 moderate known drug interactions in our database — Interferon Beta-1b isn’t one of them. If you take anything else, check it against the full list below.

Moderate 87 No known interaction 2,743 (incl. Interferon Beta-1b)
Taking anything else?

Check Another of Your Medications Against Hound's Tongue

Covers the 2,830 medications we’ve checked against Hound's Tongue. Pick one to open its full report.

What to actually watch for

What Hound's Tongue Itself Has Been Linked To

This is not an interaction — nothing below involves Interferon Beta-1b. It is the side-effect record for Hound's Tongue on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Hound's Tongue, this list is the first place to look.

  • Diarrhea / Vomiting Additional detail

    “The pyrrolizidine alkaloid (PA) constituents of hound's tongue are hepatotoxic. Chronic exposure to other plants containing hepatotoxic PA constituents is associated with veno-occlusive disease (VOD). Subacute VOD causes vague symptoms with persistent liver enlargement. Symptoms of acute VOD include epigastric pain, vomiting and diarrhea, and ascites formation within several days.”

    Hound's Tongue · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 12841. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
    2. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
    3. 4021. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.

Everything above comes from the Natural Medicines adverse-effect record for Hound's Tongue — expand a row for the licensed statement it rests on. We haven’t matched Interferon Beta-1b to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Interferon Beta-1b.

Special populations

Hound's Tongue in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Hound's tongue preparations containing pyrrolizidine alkaloid (PA) constituents might be teratogenic and hepatotoxic. There is insufficient reliable information available about the safety of using PA-free hound's tongue products during pregnancy.

Lactation Likely Unsafe

When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in hound's tongue are excreted in milk. There is insufficient reliable information available about the safety of using PA-free hound's tongue products during lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Interferon Beta-1b

This page covers Hound's Tongue only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Interferon Beta-1b page lists 57 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Alfalfa (moderate) and Angelica Archangelica (moderate).

By severity: 3 major · 53 moderate · 1 minor.

From our pharmacist’s overview on the Interferon Beta-1b page

“If you inject interferon beta-1b (Betaseron, Betaferon, Extavia) for multiple sclerosis, this supplement list is one to take seriously, mostly because of your liver. Interferon beta-1b can raise liver enzymes on its own, and 38 of the 57 ingredients on file add their own liver stress on top of that.”

Reviewed by 2 · Jul 18, 2026

Open the Interferon Beta-1b interaction page

One more smart check

Taking Hound's Tongue as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Hound's Tongue, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hound's Tongue. Even though Hound's Tongue itself has no known interaction with Interferon Beta-1b, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hound's Tongue and Interferon Beta-1b Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hound's Tongue
Top half

#613 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Interferon Beta-1b
Top 10%

#258 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hound's Tongue reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Hound's Tongue and Interferon Beta-1b records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hound's Tongue

What is Hound's Tongue?

  • Minor wounds and skin irritation
  • Coughs and sore throat
  • Hemorrhoids
  • Burns and bruises
  • Diarrhea

Hound's Tongue is a traditional folk remedy used mostly on the skin and for coughs, but there is little to no reliable human research showing it works. More importantly, it contains pyrrolizidine alkaloids that can seriously harm the liver, so internal use is generally discouraged. Talk with a pharmacist or doctor before using it in any form.

Cynoglossum officinale · Boraginaceae · Leaves and roots · Dried herb, topical poultice, ointment, tincture, tea

An interaction check asks whether these two react with each other — it does not ask whether Hound's Tongue is a good idea for someone in your situation. Here is what our Hound's Tongue record says about it on its own.

Hound's Tongue: dosing

There is no established safe or standardized dose for Hound's Tongue. In most cases, safer and better-studied alternatives are available for the conditions people use this plant for.

From our Hound's Tongue monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hound's Tongue monograph & all interactions
Medication

About Interferon Beta-1b Injection

What Is Interferon Beta-1b Injection Used For?

Brand names: Betaseron, Betaferon, Extavia

  • Interferon beta-1b injection is used to reduce episodes of symptoms in patients with relapsing-remitting (course of disease where symptoms flare up from time to time) of multiple sclerosis (MS, a disease in which the nerves do not function properly and patients may experience weakness, numbness, loss of muscle coordination and problems with vision, speech, and bladder control). Interferon beta-1b is in a class of medications called immunomodulators. It is not known exactly how interferon beta-1b works to treat MS.

Most-Reported Side Effects for Interferon Beta-1b

From FAERS, the FDA’s public side-effect reporting system (19,057 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Influenza like illness 1,402 reports
Multiple sclerosis relapse 1,344 reports
Fatigue 1,198 reports
Injection site pain 1,198 reports
Multiple sclerosis 1,167 reports
See full Interferon Beta-1b Injection drug information
Keep checking

Other Drugs & Hound's Tongue

Browse every other medication we’ve checked against Hound's Tongue — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
87Moderate
0Minor
2,742No known interaction
87 Moderate 2,742 No interaction
Moderate

87 interactions

Showing 60 of 87 moderate interactions — see all 87 on the Hound's Tongue page.

No interaction 2,742 drugs checked — show the list

We also checked Hound's Tongue against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,742 medications checked with no known interaction — see the full Hound's Tongue list.

See the full Hound's Tongue interactions page
See every supplement checked against Interferon Beta-1b, ranked by severity
Evidence & sources

Hound's Tongue References

The 4 references that drive our Hound's Tongue monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hound's Tongue and Interferon Beta-1b Together: Common Questions

Is it safe to take Hound's Tongue with Interferon Beta-1b?
We do not list a known interaction between Hound's Tongue and Interferon Beta-1b. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Hound's Tongue and Interferon Beta-1b combination checked?
Interactions in our licensed database are recorded against drug classes. Interferon Beta-1b is filed under 2 classifications, and Hound's Tongue has documented interactions with 1 drug class — none of Interferon Beta-1b's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Hound's Tongue interact with any other medications?
Yes. Hound's Tongue has 87 documented drug interactions in our database — Interferon Beta-1b is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Interferon Beta-1b interact with any supplements?
Yes. Interferon Beta-1b has documented interactions with 57 supplements in our database — Hound's Tongue is not one of them. The Interferon Beta-1b interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hound's Tongue monograph Uses, safety profile, and every drug interaction in one place Interferon Beta-1b Injection drug information The full plain-English guide to this medication Interferon Beta-1b supplement interactions Every supplement checked against Interferon Beta-1b, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Interferon Beta-1b and Hound's Tongue?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.