Drug & supplement interaction

Hound's Tongue + Mobocertinib Succinate

Mobocertinib Succinate brand name: Exkivity.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Hound's Tongue and Mobocertinib Succinate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Hound's Tongue and Mobocertinib Succinate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mobocertinib Succinate and Hound's Tongue in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hound's Tongue safety at a glance

Hound's Tongue overall Avoid It contains liver-toxic pyrrolizidine alkaloids, so internal use is not recommended.

Pregnancy Likely Unsafe When used orally. Hound's tongue preparations containing pyrrolizidine alkaloid (PA) constituents might be teratogenic and hepatotoxic. There is insufficient re... Read the full pregnancy detail

Breastfeeding Likely Unsafe When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in hound's tongue are excreted in milk. There is insufficient reliable information availa... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mobocertinib Succinate and Hound's Tongue? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Mobocertinib Succinate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Mobocertinib Succinate is filed under 3 classifications — qt interval-prolonging drugs, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Hound's Tongue has documented interactions with 1 drug class — the most serious being cytochrome p450 3a4 (cyp3a4) inducers (moderate) — and none of Mobocertinib Succinate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Hound's Tongue Does Interact With Other Medications

Hound's Tongue has 87 moderate known drug interactions in our database — Mobocertinib Succinate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 87 No known interaction 2,743 (incl. Mobocertinib Succinate)

Taking anything else?

Check Another of Your Medications Against Hound's Tongue

Covers the 2,830 medications we’ve checked against Hound's Tongue. Pick one to open its full report.

What to actually watch for

What Hound's Tongue Itself Has Been Linked To

This is not an interaction — nothing below involves Mobocertinib Succinate. It is the side-effect record for Hound's Tongue on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Hound's Tongue, this list is the first place to look.

Diarrhea / Vomiting Additional detail
“The pyrrolizidine alkaloid (PA) constituents of hound's tongue are hepatotoxic. Chronic exposure to other plants containing hepatotoxic PA constituents is associated with veno-occlusive disease (VOD). Subacute VOD causes vague symptoms with persistent liver enlargement. Symptoms of acute VOD include epigastric pain, vomiting and diarrhea, and ascites formation within several days.”

Hound's Tongue · Natural Medicines adverse-effect record, reported in diarrhea.
3 sources cited

12841. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed

12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.

4021. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.

Everything above comes from the Natural Medicines adverse-effect record for Hound's Tongue — expand a row for the licensed statement it rests on. We haven’t matched Mobocertinib Succinate to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Mobocertinib Succinate.

Special populations

Hound's Tongue in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Hound's tongue preparations containing pyrrolizidine alkaloid (PA) constituents might be teratogenic and hepatotoxic. There is insufficient reliable information available about the safety of using PA-free hound's tongue products during pregnancy.

Lactation Likely Unsafe

When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in hound's tongue are excreted in milk. There is insufficient reliable information available about the safety of using PA-free hound's tongue products during lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Mobocertinib Succinate

This page covers Hound's Tongue only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mobocertinib Succinate page lists 146 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 98 moderate · 40 minor.

From our pharmacist’s overview on the Mobocertinib Succinate page

“Mobocertinib (Exkivity) is a targeted therapy for a hard-to-treat lung cancer, which makes dosing precision matter and this list worth real caution. Most of the 146 supplements on file can shift the drug's blood level, because mobocertinib is cleared by CYP3A4, an enzyme many botanicals speed up or slow down.”

Reviewed by 2 · Jul 18, 2026

Open the Mobocertinib Succinate interaction page

One more smart check

Taking Hound's Tongue as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Hound's Tongue, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hound's Tongue. Even though Hound's Tongue itself has no known interaction with Mobocertinib Succinate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hound's Tongue and Mobocertinib Succinate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hound's Tongue

Steady interest

#1,129 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Mobocertinib Succinate

Steady interest

#2,322 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hound's Tongue reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Hound's Tongue and Mobocertinib Succinate records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Hound's Tongue

What is Hound's Tongue?

Minor wounds and skin irritation
Coughs and sore throat
Hemorrhoids
Burns and bruises
Diarrhea

Hound's Tongue is a traditional folk remedy used mostly on the skin and for coughs, but there is little to no reliable human research showing it works. More importantly, it contains pyrrolizidine alkaloids that can seriously harm the liver, so internal use is generally discouraged. Talk with a pharmacist or doctor before using it in any form.

Cynoglossum officinale · Boraginaceae · Leaves and roots · Dried herb, topical poultice, ointment, tincture, tea

An interaction check asks whether these two react with each other — it does not ask whether Hound's Tongue is a good idea for someone in your situation. Here is what our Hound's Tongue record says about it on its own.

Hound's Tongue: dosing

There is no established safe or standardized dose for Hound's Tongue. In most cases, safer and better-studied alternatives are available for the conditions people use this plant for.

From our Hound's Tongue monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hound's Tongue monograph & all interactions

Medication

About Mobocertinib

What Is Mobocertinib Used For?

Brand name: Exkivity

Mobocertinib is used to treat a certain type of non-small cell lung cancer (NSCLC) that cannot be removed by surgery and has spread to other parts of the body either during or after treatment with platinum chemotherapy medications. Mobocertinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells and may help shrink tumors.

See full Mobocertinib drug information

Keep checking

Other Drugs & Hound's Tongue

Browse every other medication we’ve checked against Hound's Tongue — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

87Moderate

0Minor

2,742No known interaction

87 Moderate 2,742 No interaction

Moderate

87 interactions

Showing 60 of 87 moderate interactions — see all 87 on the Hound's Tongue page.

No interaction 2,742 drugs checked — show the list

We also checked Hound's Tongue against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,742 medications checked with no known interaction — see the full Hound's Tongue list.

See the full Hound's Tongue interactions page

See every supplement checked against Mobocertinib Succinate, ranked by severity

Evidence & sources

Hound's Tongue References

The 4 references that drive our Hound's Tongue monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hound's Tongue and Mobocertinib Succinate Together: Common Questions

Is it safe to take Hound's Tongue with Mobocertinib Succinate?

We do not list a known interaction between Hound's Tongue and Mobocertinib Succinate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Hound's Tongue and Mobocertinib Succinate combination checked?

Interactions in our licensed database are recorded against drug classes. Mobocertinib Succinate is filed under 3 classifications, and Hound's Tongue has documented interactions with 1 drug class — none of Mobocertinib Succinate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Hound's Tongue interact with any other medications?

Yes. Hound's Tongue has 87 documented drug interactions in our database — Mobocertinib Succinate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Mobocertinib Succinate interact with any supplements?

Yes. Mobocertinib Succinate has documented interactions with 146 supplements in our database — Hound's Tongue is not one of them. The Mobocertinib Succinate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hound's Tongue monograph Uses, safety profile, and every drug interaction in one place Mobocertinib drug information The full plain-English guide to this medication Mobocertinib Succinate supplement interactions Every supplement checked against Mobocertinib Succinate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mobocertinib Succinate and Hound's Tongue?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.