Drug & supplement interaction

Japanese Persimmon + Atorvastatin

Atorvastatin brand name: Atorvaliq.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Japanese Persimmon and Atorvastatin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Japanese Persimmon and Atorvastatin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Atorvastatin and Japanese Persimmon in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Japanese Persimmon safety at a glance

Japanese Persimmon overall Use caution The fruit is safe as food, but eating large amounts of unripe persimmons may cause hard masses (bezoars) in the stomach.
Pregnancy Use caution Eating the fruit as food is likely fine, but concentrated leaf or calyx supplements have not been well studied, so avoid those.
Breastfeeding Use caution The fruit as food is likely fine, but there is not enough data on concentrated supplements, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Atorvastatin and Japanese Persimmon? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Atorvastatin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Atorvastatin is filed under 7 classifications — including hmg-coa reductase inhibitors ("statins"), organic anion-transporting polypeptide substrates (oatp), glucuronidated drugs. Japanese Persimmon has documented interactions with 2 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate) and antihypertensive drugs (moderate) — and none of Atorvastatin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Japanese Persimmon Does Interact With Other Medications

Japanese Persimmon has 289 moderate known drug interactions in our database — Atorvastatin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 289 No known interaction 2,541 (incl. Atorvastatin)
Taking anything else?

Check Another of Your Medications Against Japanese Persimmon

Covers the 2,830 medications we’ve checked against Japanese Persimmon. Pick one to open its full report.

Overlapping uses

What Atorvastatin Is Prescribed For, and What Japanese Persimmon Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Atorvastatin is a prescription medicine with approved uses on its FDA label. Japanese Persimmon is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Atorvastatin is prescribed for: Atorvastatin is used alongside a healthy diet to lower LDL ("bad") cholesterol, triglycerides (blood fats), and other harmful lipids, while raising HDL ("good") cholesterol. It treats primary hyperlipidemia (high cholesterol), mixed dyslipidemia (mixed abnormal blood fats), hypertriglyceridemia (high triglycerides), and inherited conditions such as heterozygous and homozygous familial hypercholesterolemia — including in children aged 10 and older. Beyond cholesterol control, atorvastatin is used to reduce the risk of heart attack, stroke, revascularization procedures, and angina (chest pain) in adults with coronary heart disease or multiple risk factors for it — including adults with type 2 diabetes who have risk factors for heart disease even without a confirmed heart disease diagnosis.

Japanese Persimmon has been studied for:

  • Hyperlipidemia studied, not established Japanese Persimmon has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Japanese Persimmon for hyperlipidemia

    One small clinical study in patients with elevated cholesterol levels shows that consuming cookie bars containing tannin-rich fiber from unripe Japanese persimmon fruit 3 or 5 grams three times daily before meals for 12 weeks lowers cholesterol levels when compared with placebo.

    1 source cited
    1. 100446. Gato N, Kadowaki A, Hashimoto N, Yokoyama S, Matsumoto K. Persimmon fruit tannin-rich fiber reduces cholesterol levels in humans. Ann Nutr Metab. 2013;62(1):1-6. PubMed

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Atorvastatin on your own; if you are taking Japanese Persimmon for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Japanese Persimmon or Atorvastatin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Japanese Persimmon or Atorvastatin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Atorvastatin

This page covers Japanese Persimmon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atorvastatin page lists 181 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Beer (major), Grapefruit (major) and Green Tea (major).

By severity: 9 major · 136 moderate · 36 minor.

From our pharmacist’s overview on the Atorvastatin page

“Grapefruit is the entry to understand first. Atorvastatin (Atorvaliq) is cleared by an enzyme called CYP3A4, and grapefruit blocks that enzyme, letting statin levels climb along with the risk of side effects like muscle pain.”

Reviewed by 2 · Jul 18, 2026

Open the Atorvastatin interaction page

One more smart check

Taking Japanese Persimmon as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Japanese Persimmon, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Japanese Persimmon. Even though Japanese Persimmon itself has no known interaction with Atorvastatin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Japanese Persimmon and Atorvastatin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Japanese Persimmon
Steady interest

#1,448 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Atorvastatin
Top 1%

#27 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Japanese Persimmon reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Japanese Persimmon and Atorvastatin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Japanese Persimmon

What is Japanese Persimmon?

  • High blood pressure
  • Cough and hiccups (traditional use)
  • Antioxidant support
  • Digestive health and fiber
  • Skin and general wellness

Japanese persimmon is a nutritious fruit rich in fiber, vitamins, and antioxidant plant compounds, and its leaves and calyx are used in traditional medicine. While eating the fruit as food is generally safe and healthy, the evidence for concentrated supplements or leaf extracts treating specific conditions is limited. Talk to your pharmacist or doctor before using persimmon products medicinally.

Diospyros kaki · Ebenaceae · Fruit, leaves, and the dried fruit calyx (persimmon stalk) · Fresh or dried fruit, tea (often from leaves), powder, capsules, and extracts

An interaction check asks whether these two react with each other — it does not ask whether Japanese Persimmon is a good idea for someone in your situation. Here is what our Japanese Persimmon record says about it on its own.

Japanese Persimmon: dosing

There is no standardized or proven medicinal dose for persimmon supplements. As a food, persimmon is simply eaten as a fresh or dried fruit. For leaf teas, powders, and capsules, the right amount varies by product.If you choose to use a persimmon supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Japanese Persimmon monograph — the full record covers uses, side effects and every documented interaction.

Read the full Japanese Persimmon monograph & all interactions
Medication

About Atorvastatin

What Is Atorvastatin Used For?

Brand name: Atorvaliq

Atorvastatin is used alongside a healthy diet to lower LDL ("bad") cholesterol, triglycerides (blood fats), and other harmful lipids, while raising HDL ("good") cholesterol. It treats primary hyperlipidemia (high cholesterol), mixed dyslipidemia (mixed abnormal blood fats), hypertriglyceridemia (high triglycerides), and inherited conditions such as heterozygous and homozygous familial hypercholesterolemia — including in children aged 10 and older.

Beyond cholesterol control, atorvastatin is used to reduce the risk of heart attack, stroke, revascularization procedures, and angina (chest pain) in adults with coronary heart disease or multiple risk factors for it — including adults with type 2 diabetes who have risk factors for heart disease even without a confirmed heart disease diagnosis.

See full Atorvastatin drug information
Keep checking

Other Drugs & Japanese Persimmon

Browse every other medication we’ve checked against Japanese Persimmon — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
289Moderate
0Minor
2,540No known interaction
289 Moderate 2,540 No interaction
Moderate

289 interactions

Showing 60 of 289 moderate interactions — see all 289 on the Japanese Persimmon page.

No interaction 2,540 drugs checked — show the list

We also checked Japanese Persimmon against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,540 medications checked with no known interaction — see the full Japanese Persimmon list.

See the full Japanese Persimmon interactions page
See every supplement checked against Atorvastatin, ranked by severity
Evidence & sources

Japanese Persimmon References

The 6 references that drive our Japanese Persimmon monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hibino G, Nadamoto T, Fujisawa F, Fushiki T. Regulation of the peripheral body temperature by foods: a temperature decrease induced by the Japanese persimmon (kaki, Diospyros kaki). Biosci Biotechnol Biochem 2003;67:23-8. .
  2. Akdoğan RA, Türkyilmaz S, Sipahi T, Uzun DY, Ozgür O. Gastric outlet syndrome caused by persimmon (Diospyros kaki) bezoars. Turk J Gastroenterol. 2009;20(1):72-4.
  3. Gato N, Kadowaki A, Hashimoto N, Yokoyama S, Matsumoto K. Persimmon fruit tannin-rich fiber reduces cholesterol levels in humans. Ann Nutr Metab. 2013;62(1):1-6. PubMed
  4. Khan MM, Tran BQ, Jang YJ, et al. Assessment of the Therapeutic Potential of Persimmon Leaf Extract on Prediabetic Subjects. Mol Cells. 2017;40(7):466-475. PubMed
  5. Sa YS, Kim SJ, Choi HS. The anticoagulant fraction from the leaves of Diospyros kaki L. has an antithrombotic activity. Arch Pharm Res. 2005;28(6):667-74.
  6. Yamagata Y, Saito K, Hirano K, et al. Obstruction in the third portion of the duodenum due to a diospyrobezoar: a case report. BMC Surg. 2017;17(1):117. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Japanese Persimmon and Atorvastatin Together: Common Questions

Is it safe to take Japanese Persimmon with Atorvastatin?
We do not list a known interaction between Japanese Persimmon and Atorvastatin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Japanese Persimmon and Atorvastatin used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Japanese Persimmon in each. That is a conversation for your prescriber, especially if Atorvastatin is being adjusted to a target.
How was the Japanese Persimmon and Atorvastatin combination checked?
Interactions in our licensed database are recorded against drug classes. Atorvastatin is filed under 7 classifications, and Japanese Persimmon has documented interactions with 2 drug classes — none of Atorvastatin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Japanese Persimmon interact with any other medications?
Yes. Japanese Persimmon has 289 documented drug interactions in our database — Atorvastatin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Atorvastatin interact with any supplements?
Yes. Atorvastatin has documented interactions with 181 supplements in our database — Japanese Persimmon is not one of them. The Atorvastatin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Japanese Persimmon monograph Uses, safety profile, and every drug interaction in one place Atorvastatin drug information The full plain-English guide to this medication Atorvastatin supplement interactions Every supplement checked against Atorvastatin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Atorvastatin and Japanese Persimmon?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.